Test Price
2,800 AED✅ Home Collection Available
CLPB Gene (3-Methylglutaconic Aciduria Type 7) with Cataracts, Neurologic Involvement and Neutropenia – Genetic Test in UAE | 2800 AED | 2026 DHA Guidelines
تحليل جين CLPB (3-Methylglutaconic Aciduria Type 7) مع الساد، والمضاعفات العصبية، وقلة العدلات في الإمارات | 2800 درهم | معتمد من هيئة الصحة بدبي
Executive Summary
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015 Certified Processing. ضمان دقة تشخيصية بنسبة 99.9% من خلال معالجة معتمدة بمعيار ISO.
- Premium Logistics: Hospital-Grade Home Collection via ISO Certified Cold-Chain Home Collection & VIP Mobile Phlebotomy (8 AM - 11 PM).
- Clinical Guidance: Telephonic Post-Test Clinical Guidance with DHA-licensed specialists for result interpretation.
- Insurance: Direct Billing Verification via WhatsApp at +971 54 548 8731.
- استشارة وراثية مسبقة لرسم شجرة العائلة للمصابين بهذا الاضطراب.
Test Overview
The CLPB gene NGS test detects pathogenic variants associated with 3-methylglutaconic aciduria type 7, a rare multisystem disorder characterized by cataracts, neurologic deterioration, and neutropenia. This test provides a definitive molecular diagnosis, enabling targeted clinical management and genetic counseling. يكشف اختبار جين CLPB عن الطفرات المسببة لمرض بيلة 3-ميثيل غلوتاكونيك من النوع 7، مما يتيح التشخيص الدقيق والاستشارة الوراثية.
| Feature | Our Test (VitalGen Labs, DHA-licensed) | Closest Alternative |
|---|---|---|
| Methodology | Next-Generation Sequencing (NGS) with full CLPB gene coverage & Sanger validation | Single-gene Sanger sequencing (limited coverage) |
| Turnaround Time | 3–4 Weeks | 6–8 Weeks |
| Precision | 99.9% Analytical Sensitivity & Specificity (ISO-certified) | ~95% |
Physician Insight & Safety Protocol
“As a DHA-licensed consultant, I emphasize that this test should always be interpreted within the full clinical context. A negative result does not exclude the disorder if symptoms are highly suggestive, and genetic counseling is mandatory pre- and post-test. Your managing physician remains your primary guide.” – Dr. PRABHAKAR REDDY, DHA License No. 61713011.
⚠️ Medication Warning
Do not discontinue or adjust any prescribed medication, especially neutropenia management therapies, without consulting your treating specialist. This test provides genetic insights and does not replace urgent clinical decisions.
Exclusion Criteria & Emergency Red Flags
- Patients with acute febrile neutropenia (absolute neutrophil count < 0.5 × 10⁹/L) require immediate emergency care, not elective genetic testing.
- Uncontrolled seizure activity or acute encephalopathy: stabilize first.
- Known anaphylaxis to venipuncture materials (for blood draw) – use FTA card alternative.
- If test results are needed for urgent transplant workup, contact lab for expedited TAT (additional charges may apply).
Patient FAQ & Clinical Guidance
What does the CLPB genes test detect, and why is it important for my child?
This NGS assay identifies disease-causing mutations in the CLPB gene responsible for 3-methylglutaconic aciduria type 7, a condition marked by early cataracts, progressive neurologic disability, and severe neutropenia. Early diagnosis enables timely cataract surgery, granulocyte colony-stimulating factor (G-CSF) therapy if indicated, and preventive neurological care, significantly improving quality of life. يكشف هذا الاختبار الطفرات الجينية المسببة للمرض، مما يسمح بالتدخل المبكر لإنقاذ البصر والتعامل مع نقص المناعة.
How is the sample collected, and is it painful for my baby?
We offer a virtually painless option: a single drop of blood on an FTA card, collected by a trained pediatric phlebotomist during a home visit. For older patients, a standard venipuncture (2 mL whole blood) or extracted DNA from saliva is also accepted. The procedure adheres to DHA pediatric comfort protocols. يتم جمع العينة بأقل ألم باستخدام بطاقة FTA أو سحب دم بسيط، وفق إجراءات هيئة الصحة بدبي لراحة الأطفال.
Will my health insurance cover this in the UAE?
Most UAE-based insurance plans, including those under Thiqa and Daman, may cover genetic testing for suspected hereditary metabolic disorders when pre-authorized. Our team will verify your eligibility via WhatsApp (+971 54 548 8731) and handle direct billing once a referral from a DHA-licensed specialist is provided. قد تغطي شركات التأمين الإماراتية مثل ثقة وضمان الاختبارات الجينية عند ورود تحويل طبي. نتحقق من التغطية مباشرة عبر الواتس اب.
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توقف عن التخمين. أرسل صورة من بطاقة التأمين ووصفة الطبيب إلى فريق التحقق المعتمد من هيئة الصحة بدبي عبر الواتساب. احصل على تحديث الحالة في دقائق.
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