Test Price
2,800 AED✅ Home Collection Available
ALDOB Gene Hereditary Fructose Intolerance (HFI) Genetic Test in UAE | 2,800 AED
Executive Summary & Core Metrics
Clinical Confidence & UAE Regulatory Compliance
- ✓99.9% Diagnostic Sensitivity – Achieved via ISO 9001:2015 accredited NGS workflow (Cert: INT/EGQ/2509DA/3139), validated against curated clinical genomic databases.
- ✓DHA‑Licensed Mobile Phlebotomy – Paid hospital‑grade home collection (8 AM‑11 PM) with temperature‑controlled cold‑chain logistics; sample stability guaranteed.
- ✓Post‑Test Clinical Guidance – Telephonic interpretation session with a senior genetic counsellor to translate findings into actionable care plans.
- ✓Direct Insurance Billing Verification – WhatsApp your Emirates ID and policy number to +971 545 488 731 for real‑time coverage approval.
Executive Summary
The ALDOB gene NGS test is the most accurate molecular diagnostic method for confirming hereditary fructose intolerance (HFI) in the UAE. Performed under a DHA‑licensed framework using ISO 9001:2015 accredited next‑generation sequencing, this assay achieves greater than 99% sensitivity for pathogenic variant detection across all coding exons and splice junctions. The service includes VIP mobile phlebotomy, a post‑result genetic counselling session, and direct insurance verification.
Test Overview & Methodology
This test sequences the complete coding region and flanking intronic boundaries of the ALDOB gene, providing a definitive molecular diagnosis for hereditary fructose intolerance (HFI) – a condition that, if unrecognised, can lead to severe hypoglycaemia, liver failure, and growth retardation. Next‑generation sequencing enables simultaneous interrogation of all exons with high analytical sensitivity for single‑nucleotide variants, small insertions, and deletions.
Pre‑Test Requirement:
Prior to sampling, a detailed clinical history must be recorded, and a genetic counselling session is mandatory to construct a three‑generation pedigree documenting all family members with fructose intolerance or unexplained liver disease. This ensures accurate risk assessment and variant interpretation.
| Feature | Our NGS Test (ALDOB Full Gene) | Closest Alternative (Biochemical Assay / Single‑Site PCR) |
|---|---|---|
| Methodology | NGS (Next Generation Sequencing) – examines all exons, splice sites, and deep intronic regions | Enzymatic activity assay in liver biopsy OR targeted mutation panel (limited to a few known variants) |
| Diagnostic Yield | >99.0% pathogenic variant detection rate | ~70–80% for targeted PCR; enzyme assay requires invasive tissue |
| Turnaround Time | 3 – 4 Weeks | Biochemical: 2–3 weeks; PCR panels: 2–4 weeks but often need reflex to NGS |
| Sample Requirement | Minimally invasive – 3 mL whole blood or one drop on FTA card | Liver biopsy (enzymatic) or larger blood volume for DNA extraction |
Physician Insight & Safety Protocols
“Comprehensive ALDOB gene sequencing via NGS provides definitive molecular confirmation of hereditary fructose intolerance, enabling precise dietary interventions before metabolic decompensation occurs. The integration of three‑generation pedigree analysis with variant interpretation ensures accurate risk stratification for affected families. For any case with strong clinical suspicion and a negative NGS result, enzymatic studies or repeat sampling under strict glucose monitoring should be considered.”
– Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Medication Safety Advisory
⚠ Important Precaution
Do not discontinue any prescribed medication or dietary regimen without explicit consultation with your supervising physician. This genetic test does not replace clinical management – always maintain prescribed emergency protocols, especially for hypoglycaemia.
Exclusion Criteria & Emergency Red Flags
- Exclusion: Recent blood transfusion (<4 weeks) may lead to false‑negative results due to donor DNA interference; schedule phlebotomy accordingly.
- Exclusion: Acute febrile illness – pre‑test clinical stability is required for safe home collection.
- ER Red Flags: If the patient (especially a child) develops profound hypoglycaemia (glucose <2.5 mmol/L), prolonged vomiting, acute jaundice, or altered consciousness after fructose/sucrose ingestion, seek emergency care immediately – do not wait for test results.
Patient FAQ & Clinical Guidance
1. What does the ALDOB gene test actually diagnose?
This NGS test definitively identifies disease‑causing variants in the ALDOB gene responsible for hereditary fructose intolerance, a metabolic disorder that becomes dangerous upon fructose ingestion. A positive result confirms HFI and mandates an immediate, strict fructose‑free diet under metabolic specialist supervision. The report also clarifies carrier status for family planning.
2. How soon can I get results, and will a doctor explain them?
The standard turnaround is 3 to 4 weeks from sample receipt, and every report includes a telephonic clinical interpretation session with a genetic counsellor at no extra cost. Urgent preliminary verbal updates are available for critically ill hospitalised patients upon DHA‑licensed physician request. Home collection can be arranged within 24 hours of booking.
3. Can a child undergo this test, and is parental consent required?
Yes, this test is frequently performed on infants and children. Written consent from both parents or the legal guardian is mandatory before genetic sampling, in accordance with Federal Decree‑Law No. 4 of 2016 on Medical Liability. Our paediatric phlebotomy team uses micro‑collection FTA cards (a single drop of blood from a heel or finger prick) to minimise discomfort. The laboratory strictly adheres to Federal Decree‑Law No. 45 of 2021 on Personal Data Protection (PDPL), ensuring that no information is shared without documented authorisation.
UAE Regulatory & Data Privacy Adherence
DNA Labs UAE operates under the governance of the Dubai Health Authority (DHA) and complies with all federal data protection and healthcare technology regulations. All genetic data generated from the ALDOB gene test is processed and stored in accordance with Federal Decree‑Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Patient consent protocols follow the standards outlined in Federal Decree‑Law No. 4 of 2016 on Medical Liability. Your genomic information is encrypted, access‑controlled, and never shared with third parties without explicit written consent.
DHA Facility License Number: 1143 | DNA Labs UAE – Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE
Clinical & Logistical Metadata
| Test Name | ALDOB Gene Sequencing for Hereditary Fructose Intolerance |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3 – 4 Weeks |
| Sample Type / Matrix | Whole Blood (3 mL) or FTA Micro‑Collection Card – VIP Mobile Phlebotomy & Temperature‑Controlled Cold‑Chain Home Collection (Available daily from 8 AM to 11 PM) |
| Methodology Used | Next‑Generation Sequencing (NGS) – Full gene coding regions and splice sites |
| ICD-10-CM Code | E74.12 (Hereditary fructose intolerance) |
| LOINC Code | 94228-2 (ALDOB gene mutation analysis in Blood or Tissue by Molecular genetics method) |
| DHA Facility License & Laboratory Address | DHA Facility License Number: 1143 | DNA Labs UAE – Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
دعم ثنائي اللغة متاح
التحقق من التغطية التأمينية
Check Insurance Coverage Instantly
Stop the guesswork. Send a photo of your Insurance Card and Doctor's Prescription to our DHA-Certified Verification Team on WhatsApp.
توقف عن التخمين. أرسل صورة من بطاقة التأمين ووصفة الطبيب إلى فريق التحقق المعتمد من هيئة الصحة بدبي عبر الواتساب. احصل على تحديث الحالة في دقائق.
Available in Arabic, English, Hindi & Urdu
ISMS 27001:2022
ISO Accredited
HIPAA
All reports reviewed by DHA-Certified physicians