Test Price
2,800 AED✅ Home Collection Available
SCN5A Gene (Sick Sinus Syndrome Type 1) Genetic Test in UAE | 2800 AED
Executive Summary & Core Metrics
This ISO-accredited genetic test utilizes Next-Generation Sequencing (NGS) to deliver 99.9% diagnostic sensitivity for detecting pathogenic variants in the SCN5A gene associated with Sick Sinus Syndrome Type 1. Fully compliant with DHA standards, DNA Labs UAE offers VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection for patient convenience. The test includes mandatory pre-test genetic counseling, a three-generation pedigree analysis, and a post-test telephonic consultation with our Consultant Medical Geneticist. Direct billing verification and appointment scheduling are available via WhatsApp at +971 54 548 8731. Price: 2,800 AED.
Test Overview & Methodology
This advanced genetic test analyzes the entire coding and flanking regions of the SCN5A gene via Next-Generation Sequencing (NGS) to identify pathogenic and novel variants linked to Sick Sinus Syndrome Type 1. This inherited cardiac conduction disorder can lead to bradycardia, syncope, and an increased risk of atrial fibrillation. Early molecular diagnosis enables precise risk stratification for the patient and cascade screening for at-risk family members.
| Feature | Our NGS Test | Sanger Sequencing (Alternative) |
|---|---|---|
| Methodology | Next-Generation Sequencing (NGS) – full gene coverage | Sanger sequencing – only targeted known variants |
| Clinical Sensitivity | Detects all pathogenic and novel variants | Limited to pre‑identified familial mutation |
| Turnaround Time | 3–4 Weeks | 2–3 Weeks |
| Sample Type | Whole blood, extracted DNA, or FTA card | Blood or DNA |
| Ideal For | Diagnosis, family screening, athlete clearance | Confirming a known familial variant |
Physician Insight & Safety Protocols
“As a Consultant Medical Geneticist, I emphasize that a positive SCN5A result requires careful integration with the patient’s clinical phenotype, ECG findings, and family history. Genetic testing is a powerful tool for risk stratification but must never replace regular cardiology follow-up or lead to abrupt discontinuation of prescribed medications. Cascade screening for first-degree relatives is strongly recommended to identify at-risk individuals early and enable preventive management.”
— Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA License: 9294403
Medication Advisory
Do not discontinue prescribed antiarrhythmic medications or beta-blockers without consulting your physician. Abrupt cessation can be life-threatening and may lead to severe bradycardia or arrhythmic complications.
Exclusion Criteria & Emergency Red Flags
- Exclusion: Acute myocardial infarction or unstable angina within the last 4 weeks.
- Exclusion: Active, uncontrolled sustained ventricular tachycardia.
- Red Flag: New‑onset syncope or presyncope → Seek immediate emergency care.
- Red Flag: Severe bradycardia with heart rate < 30 bpm or pauses > 3 seconds.
- This test requires informed consent from the patient or legal guardian as per Federal Decree-Law No. 4 of 2016 on Medical Liability.
Patient FAQ & Clinical Guidance
1. Who should consider the SCN5A genetic test for Sick Sinus Syndrome?
This test is essential for patients with unexplained bradycardia, familial sick sinus syndrome, and athletes undergoing cardiac screening. It is indicated when there is suspected inherited sinus node dysfunction, ECG findings of sinus pauses or chronotropic incompetence, and for first-degree relatives of a proband with a known SCN5A mutation. Athletes seeking definitive clearance from concealed arrhythmia syndromes also benefit from this comprehensive NGS analysis.
2. What does a positive SCN5A result mean for my family?
A positive result confirms a hereditary arrhythmia syndrome, necessitating family cascade screening for early prevention. It indicates an inherited risk that may require clinical evaluation of first-degree relatives through targeted mutation testing. Early identification allows for lifestyle adjustments, periodic Holter monitoring, and if indicated, prophylactic pacemaker placement under specialist guidance. Genetic counselling is mandatory to communicate risks accurately.
3. How does the home collection process work for genetic tests?
We offer VIP mobile phlebotomy with cold-chain logistics, preserving DNA integrity for accurate NGS analysis. After scheduling via WhatsApp, a DHA-licensed phlebotomist arrives with a temperature-controlled transport kit. Whole blood or FTA card sample collection takes under 10 minutes. The specimen is immediately sealed, tracked via secure courier, and transported at 2–8°C to our ISO-certified laboratory for processing.
UAE Regulatory & Data Privacy Adherence
DNA Labs UAE strictly adheres to Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. All genetic data is classified as highly sensitive and is encrypted, stored, and processed in compliance with local and international standards. Patient consent for genetic testing is obtained and managed per Federal Decree-Law No. 4 of 2016 on Medical Liability.
Clinical & Logistical Metadata
| Test Name | SCN5A Gene (Sick Sinus Syndrome Type 1) Genetic Test |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3–4 Weeks |
| Sample Type / Matrix | Whole Blood (EDTA), Extracted DNA, or FTA Card |
| Methodology Used | Next-Generation Sequencing (NGS) – Full Gene Coverage |
| ICD-10-CM Code | I49.5 |
| LOINC Code | 21636-6 |
| DHA Facility License & Address | License No: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | DNA Labs UAE |
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