Test Price
2,800 AED✅ Home Collection Available
VPS33B Gene Analysis (Next-Generation Sequencing) for Arthrogryposis, Renal Dysfunction, and Cholestasis Type 1 (ARC Syndrome) in the UAE | AED 2,800
Executive Summary & Core Metrics
✓ Accuracy: 99.9% diagnostic sensitivity via ISO-accredited processing
✓ Premium hospital-grade home collection via ISO-certified cold-chain
✓ Telephonic post-test clinical guidance by DHA-licensed genetic counselor
✓ Direct insurance billing verification via WhatsApp +971 54 548 8731
Test Overview & Methodology
This VPS33B gene test employs advanced Next-Generation Sequencing (NGS) to fully analyze the VPS33B gene, diagnosing Arthrogryposis, Renal dysfunction, and Cholestasis type 1 (ARC syndrome), a severe autosomal recessive multi-organ disorder. The analysis covers all exons and flanking intronic regions for comprehensive variant detection with >99.9% sensitivity.
| Feature | Our Test (VPS33B NGS) | Closest Alternative |
|---|---|---|
| Precision | Full gene sequencing (all exons + flanking regions) >99.9% sensitivity | Single-gene Sanger sequencing, may miss deep intronic variants |
| Methodology | Next-Generation Sequencing (NGS) with bioinformatics validation | Traditional Sanger sequencing |
| Turnaround Time | 3 to 4 weeks | 4 to 6 weeks (limited labs) |
Physician Insight & Safety Protocols
“As a DHA-licensed Consultant Medical Genetics, I emphasize that VPS33B NGS results must be interpreted alongside detailed renal, hepatic, and dermatological evaluations. A positive finding confirms the diagnosis, but a negative result does not exclude ARC syndrome if clinical suspicion remains high. Multidisciplinary collaboration is essential.”
- Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Advisory: Multidisciplinary Interpretation Recommended
Genetic test results should be correlated with clinical findings. Discuss all findings with a geneticist, nephrologist, and hepatologist to guide management. Our lab offers complimentary follow-up telephonic consultation with a clinical geneticist for all positive or uncertain variants.
Exclusion Criteria & Emergency Red Flags
- Exclusion: Inability to provide a blood sample due to severe anemia, bleeding disorders, or recent chemotherapy (may affect DNA quality). Neonatal screening is not currently validated for this test.
- Exclusion: Minors under 18 years require legal guardian consent per UAE Federal Decree-Law No. 4 of 2016 on Medical Liability.
- Red Flags – Seek urgent care: Sudden worsening of jaundice, severe itching, signs of acute kidney injury (decreased urination), or uncontrolled bleeding. These may indicate disease progression and require immediate medical attention.
Patient FAQ & Clinical Guidance
1. What is the VPS33B gene test, and what does it diagnose?
This NGS test identifies mutations in the VPS33B gene to confirm ARC syndrome, a rare autosomal recessive multi-organ disorder characterized by arthrogryposis (joint contractures), renal tubular dysfunction, and cholestasis.
2. What sample types are accepted, and how is the sample collected?
We accept whole blood, extracted DNA, or a dried blood spot on an FTA card. VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection is available daily from 8 AM to 11 PM. Our ISO-certified phlebotomists ensure safe transport to the laboratory.
3. How long will the results take, and what support is provided?
Results are ready in 3 to 4 weeks. You will receive free telephonic post-test clinical guidance from our genetic counselor to interpret findings. If a variant is detected, we facilitate specialist referrals to nephrologists or hepatologists for further management.
UAE Regulatory & Data Privacy Adherence
Your data is protected. This laboratory operates under DHA Facility License No. 1143 and complies with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. All genetic results are stored encrypted and accessed only by authorized clinical staff. Your consent is obtained per Federal Decree-Law No. 4 of 2016 on Medical Liability.
Clinical & Logistical Metadata
| Test Name | VPS33B Gene Analysis (Next-Generation Sequencing) for ARC Syndrome |
| Price (AED) | 2,800 |
| Turnaround Time | 3 to 4 weeks |
| Sample Type / Matrix | Whole blood (peripheral), extracted DNA, or dried blood spot on FTA card |
| Methodology Used | Next-Generation Sequencing (NGS) with bioinformatics analysis |
| ICD-10-CM Code | Q87.8 |
| LOINC Code | 82439-2 |
| DHA Facility License & Laboratory Address Invariants | Licensed by DHA – License No. 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | Corporate Lab: DNA Labs UAE |
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ISMS 27001:2022
ISO Accredited
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All reports reviewed by DHA-Certified physicians