Test Price
2,800 AED✅ Home Collection Available
IRF6 Gene Van der Woude Syndrome Type 1 Genetic Test in UAE | DNA Labs UAE | 2800 AED
Executive Summary & Core Metrics
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015 Certified Processing (Cert: INT/EGQ/2509DA/3139).
- Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection available daily from 8 AM to 11 PM.
- Clinical Guidance: Complimentary Telephonic Post-Test Clinical Interpretation by a DHA-licensed genetics counsellor.
- Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.
- Price: 2,800 AED – All-inclusive covering sample collection, NGS analysis, and post-test consultation.
- Turnaround Time: 3–4 weeks from sample receipt.
Test Overview & Methodology
The IRF6 Gene Van der Woude Syndrome Type 1 Genetic Test utilises Next‑Generation Sequencing to detect single nucleotide variants, small indels, and copy number alterations in the IRF6 gene, the definitive genetic cause of Van der Woude syndrome (VWS1). This assay is indicated for individuals presenting with cleft lip with or without cleft palate, congenital lip pits, or a family history suggestive of autosomal dominant inheritance. Results guide surgical planning, speech therapy, genetic counselling, and prenatal counselling for at-risk families.
| Feature | Our NGS IRF6 Test | Single‑Gene Sanger Sequencing |
|---|---|---|
| Method | Next‑Generation Sequencing (NGS) | Sanger Sequencing |
| Variant Detection | SNVs, indels, CNVs (full gene) | SNVs, small indels only |
| Turnaround Time | 3–4 weeks | 6–8 weeks |
| Clinical Sensitivity | >99.9% | ~95% |
Physician Insight & Safety Protocols
“A definitive IRF6 diagnosis empowers families to coordinate early craniofacial surgery, speech therapy, and genetic counselling across multiple specialties. In my practice, I stress that genetic findings must always be integrated with clinical examination and a three-generation pedigree; a positive result alone does not dictate treatment urgency. Multidisciplinary care remains the gold standard for Van der Woude syndrome.”
– Lina Osama Zaki Quteineh | Consultant Medical Genetics | DHA Registration ID: 9294403
Medication & Feeding Safety Advisory
Warning: Do not discontinue, adjust, or postpone any prescribed medication, feeding protocol, or surgical intervention based solely on genetic test results. Always consult your treating paediatrician, craniofacial surgeon, or clinical geneticist before making any changes to your child's care plan. In emergency scenarios such as severe respiratory distress, cyanosis during feeding, or suspected aspiration pneumonia, seek immediate emergency care.
Exclusion Criteria & Safety Red Flags
- Recent blood transfusion within the last 2 weeks or a history of allogeneic bone‑marrow transplant – donor DNA may confound sequencing results and lead to false interpretation.
- Inability to provide a detailed clinical history and a complete three‑generation pedigree; pre-test genetic counselling is mandatory for informed consent and result contextualisation.
- Emergency Red Flags: Newborn with cleft palate presenting with severe respiratory distress, cyanosis during feeding, or aspiration pneumonia – immediate emergency assessment is required.
- Incidental findings may be identified; a board‑certified clinical geneticist must review and communicate all secondary results to the referring physician.
Patient FAQ & Clinical Guidance
1. What is the IRF6 gene Van der Woude syndrome test and who should consider it?
This advanced NGS test detects IRF6 gene mutations causing Van der Woude syndrome, recommended for individuals with cleft lip/palate and lip pits. The assay is indicated for children or adults with characteristic oral‑facial features, family history of VWS, or prenatal ultrasound findings of cleft. A positive result directs surgical planning, speech therapy, and genetic counselling. Paediatricians, craniofacial surgeons, or clinical geneticists typically order it after a dysmorphology evaluation.
2. How is the sample collected and what is the turnaround time?
A simple blood draw, extracted DNA, or a single drop of blood on an FTA card is collected by our DHA‑licensed phlebotomists. VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection is available daily from 8 AM to 11 PM. For infants, a heel‑prick FTA card offers a painless alternative. Once the sample reaches our CLIA‑compliant laboratory, NGS analysis and bioinformatics interpretation require 3–4 weeks.
3. Does insurance cover the IRF6 gene test and what does the 2,800 AED fee include?
Many UAE insurers cover medically necessary genetic testing. Our patient support team verifies your insurance benefits instantly via WhatsApp at +971 54 548 8731. The all‑inclusive price covers the genetic counselling session, sample transport, DNA extraction, NGS sequencing, and a 20‑minute telephone interpretation with a genetics counsellor – no hidden costs.
UAE Regulatory & Data Privacy Adherence
DNA Labs UAE operates under DHA Facility License Number 1143 and adheres to the UAE Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) for all patient data handling, storage, and sharing. All health information is processed in compliance with Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields, ensuring secure electronic medical records and encrypted data transmission. Clinical testing safety and patient consent follow Federal Decree-Law No. 4 of 2016 on Medical Liability. Our laboratory holds ISO 9001:2015 certification (Cert: INT/EGQ/2509DA/3139) and follows CLIA-equivalent quality standards.
Clinical & Logistical Metadata
| Test Name | IRF6 Gene Van der Woude Syndrome Type 1 Genetic Test (NGS) |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3–4 weeks |
| Sample Type / Matrix | Whole Blood (EDTA), Extracted DNA, or FTA Card |
| Methodology Used | Next-Generation Sequencing (NGS) – Full gene sequencing including SNV, indel, and CNV analysis |
| ICD-10-CM Code | Q87.0 (Congenital malformation syndromes predominantly affecting facial appearance) |
| LOINC Code | 94139-6 (IRF6 gene targeted mutation analysis in Blood or Tissue by Sequencing) |
| DHA Facility License & Laboratory Address | DHA License No: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | DNA Labs UAE |
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