Test Price
2,800 AEDโ Home Collection Available
VCP Gene Amyotrophic Lateral Sclerosis Type 14 Genetic Test in UAE | 2800 AED | DHA Licensed
Executive Summary & Core Metrics
- Diagnostic Precision: 99.9% analytical sensitivity via ISO 9001:2015 validated next-generation sequencing (NGS) platform.
- Premium Logistics: VIP mobile phlebotomy with temperature-controlled cold-chain home collection, available daily 8 AM to 11 PM.
- Clinical Guidance: Post-test telephonic consultation for result interpretation with our specialised medical genetics team.
- Insurance Facilitation: Direct billing verification and approval assistance via WhatsApp +971 54 548 8731.
Test Overview & Methodology
This next-generation sequencing (NGS) test definitively detects pathogenic variants in the VCP gene, the principal cause of autosomal dominant amyotrophic lateral sclerosis type 14. The assay provides comprehensive coverage of all coding exons and splice junctions, enabling identification of point mutations, small indels, and copy number variations with high confidence.
| Parameter | Our NGS Test | Closest Alternative (Conventional Sanger) |
|---|---|---|
| Precision & Sensitivity | 99.9% analytical sensitivity, full gene coverage across all exons | ~98% for known hotspots, limited to targeted exons only |
| Turnaround Time | 3โ4 weeks | 6โ8 weeks |
| Clinical Utility | Comprehensive mutation detection & copy number analysis | Point mutations and small indels only |
Interpretation by clinical neurologist, medical geneticist, and genetic counsellor.
Physician Insight & Safety Protocols
โAs a Consultant Medical Genetics, I recognise that confronting a potential ALS diagnosis brings immense anxiety for patients and families. This VCP gene test provides essential genetic insight for confirming ALS type 14, yet clinical findings, family history, and neurological examination must always guide the final diagnosis. Please continue all prescribed treatments and discuss results with your neurologist before any self-adjustment of therapy.โ
โ Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Advisory Notice โ Medication Continuity
Do not discontinue prescribed medication without consulting your doctor.
Abrupt cessation of disease-modifying therapies or symptomatic treatments for ALS can lead to rapid clinical deterioration. Always seek specialist guidance before making any changes to your medication regimen.
Safety Exclusion Criteria & Emergency Red Flags
- Not recommended for individuals who have received a blood transfusion in the past 3 weeks, as this may compromise DNA quality and test accuracy.
- Minors without a legal guardianโs consent and mandatory pre-test genetic counselling are excluded per UAE Federal Law No. 2 of 2019 provisions.
- Pregnancy does not contraindicate blood draw, but NGS analysis is not validated for prenatal diagnostic use.
- Emergency red flags: Sudden worsening of muscle weakness, difficulty breathing, or impaired swallowing require immediate hospital evaluation and should not be delayed for genetic testing.
Patient FAQ & Clinical Guidance
1. What does a positive VCP mutation result mean?
A positive result confirms a genetic predisposition to ALS type 14, requiring comprehensive neurological evaluation and family counselling. It does not guarantee that disease will develop, as penetrance and expressivity can vary. Predictive testing should always be accompanied by pre-test and post-test genetic counselling.
2. How accurate is this genetic test?
Our validated NGS platform delivers 99.9% diagnostic sensitivity and specificity, detecting point mutations, small insertions and deletions, and copy number variations across the entire VCP gene. Confirmatory Sanger sequencing is performed for all clinically significant variants.
3. How should I prepare for the blood draw?
No fasting or special preparation is required. A simple peripheral whole blood sample is collected at your convenience by our certified phlebotomist during a home visit or at our Dubai Healthcare City facility. The sample is transported under controlled cold-chain conditions to our ISO-certified laboratory.
UAE Regulatory & Data Privacy Adherence
Data Protection & Health Information Governance: This test and all associated patient data are handled in strict compliance with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Clinical safety and patient consent protocols follow Federal Decree-Law No. 4 of 2016 on Medical Liability. DNA Labs UAE holds ISO 9001:2015 certification (Cert: INT/EGQ/2509DA/3139) and operates under DHA Facility License Number 1143.
Clinical & Logistical Metadata
| Test Name | VCP Gene Amyotrophic Lateral Sclerosis Type 14 Genetic Test (NGS) |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3โ4 weeks from sample receipt |
| Sample Type / Matrix | Peripheral whole blood (EDTA) โ VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection available daily from 8 AM to 11 PM |
| Methodology Used | Next-Generation Sequencing (NGS) with full gene coverage including coding exons, splice junctions, and CNV analysis |
| ICD-10-CM Code | G12.21, G12.29 |
| LOINC Code | 97934-0 |
| DHA Facility License & Address | DHA Facility License Number: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | DNA Labs UAE |
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