Test Price
2,800 AED✅ Home Collection Available
TRAF3 Gene Susceptibility Test (Herpes-Specific Acute Encephalopathy, Type 5) – NGS
Executive Summary & Core Metrics
Clinical-Grade Genetic Susceptibility Testing
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015 Certified NGS Processing.
- Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection (Available daily from 8 AM to 11 PM).
- Clinical Guidance: Complimentary Telephonic Post-Test Interpretation by a DHA-Licensed Consultant Medical Geneticist.
- Insurance: Direct Billing Verification via WhatsApp at +971 54 548 8731.
- Price: 2,800 AED (all inclusive).
- Turnaround Time: 3–4 Weeks (comprehensive report with genetic counseling support).
Test Overview & Methodology
This test analyses the entire coding region of the TRAF3 gene using Next-Generation Sequencing (NGS) to detect pathogenic variants associated with acute, infection-induced encephalopathy, specifically herpes simplex-triggered episodes (susceptibility type 5). It is an essential tool for neurologists, clinical geneticists, and immunologists to confirm the molecular diagnosis, guide prophylactic antiviral strategies, and perform accurate familial risk assessment.
The methodology employs Illumina-based next-generation sequencing with 150 bp paired-end reads, target enrichment via hybridization capture, and bioinformatics analysis using ClinVar, HGMD, and ACMG guidelines. The test achieves single-nucleotide resolution and can detect copy-number variations (CNVs) across the entire TRAF3 locus.
| Feature | Our NGS Test (DHA Approved) | Standard Herpes PCR Panel |
|---|---|---|
| Precision | Single-nucleotide resolution with CNV detection across entire TRAF3 locus | Targeted pathogen DNA detection only; no host genetic analysis |
| Methodology | Next-Generation Sequencing (Illumina) + Updated Variant Databases | Real-Time PCR / Multiplex PCR |
| Turnaround Time | 3–4 weeks (comprehensive report with genetic counselling support) | 1–2 working days (infection status only) |
Physician Insight & Safety Protocols
Lina Osama Zaki Quteineh (Consultant Medical Genetics, DHA Registration ID: 9294403) notes: "This genetic test identifies inherited susceptibility to herpes-triggered acute encephalopathy, not active infection. A positive result must always be correlated with clinical history, neurological examination, and family pedigree. Early molecular diagnosis enables tailored antiviral prophylaxis and risk-appropriate monitoring for affected individuals."
Medication & Safety Advisory
⚠️ Important Warning
Do not discontinue any prescribed antiviral, immunosuppressive, or antiepileptic medication without consulting your treating physician.
Exclusion Criteria for Sample Collection: Acute febrile illness, active herpes labialis or systemic herpes infection, recent administration of DNA-disrupting agents. Emergency Red Flags: If the patient develops sudden confusion, seizures, high fever with neck stiffness, or loss of consciousness, proceed directly to the nearest emergency department – do not wait for test results.
Patient FAQ & Clinical Guidance
1. What exactly does the TRAF3 genetic test detect?
The test identifies germline mutations in the TRAF3 gene that increase vulnerability to herpes-triggered acute encephalopathy, enabling precise risk stratification. This allows clinicians to differentiate infection‑driven brain inflammation from other encephalopathies and plan prophylactic measures.
2. How accurate is this NGS compared to older methods?
With 99.9% analytical sensitivity and specificity, our next-generation sequencing detects even rare single‑nucleotide variants and copy‑number alterations across the entire TRAF3 gene. It far exceeds the resolution of Sanger sequencing or targeted genotyping, and is updated to latest variant interpretation guidelines.
3. Is home sample collection available across the UAE, and how does it work?
Yes, we offer ISO‑certified cold‑chain home phlebotomy in all Emirates from 8 AM to 11 PM, with a trained mobile nurse arriving within 60 minutes of confirmation. Samples are transported in validated temperature‑controlled containers directly to our CAP‑accredited laboratory.
4. Who will interpret my results?
A DHA-licensed Consultant Medical Geneticist provides a complimentary telephonic post-test interpretation. The comprehensive written report includes variant classification, clinical recommendations, and family screening guidance.
UAE Regulatory & Data Privacy Adherence
Compliance & Data Protection
This service strictly adheres to the Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) for all genetic and health data processing, and the Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields for secure electronic health information exchange. Clinical safety and patient consent comply with Federal Decree-Law No. 4 of 2016 on Medical Liability. Our facility operates under DHA Facility License Number 1143 and is certified ISO 9001:2015 for quality management. Genetic data is encrypted and stored on servers located within the UAE.
Clinical & Logistical Metadata
| Test Name | TRAF3 Gene Susceptibility Test (Herpes-Specific Acute Encephalopathy, Type 5) – NGS |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3–4 weeks |
| Sample Type / Matrix | Peripheral whole blood (EDTA) – VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection |
| Methodology Used | Next-Generation Sequencing (NGS) – Illumina, whole gene sequencing with CNV detection |
| ICD-10-CM Code | Z13.79 |
| LOINC Code | 95053-1 |
| DHA Facility License & Laboratory Address | License No. 1143 – Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE – DNA Labs UAE |
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