Test Price
2,800 AED✅ Home Collection Available
TPM2 Gene Arthrogryposis, Distal Type 1A Genetic Test in UAE | 2800 AED
Executive Summary & Core Metrics
- ✓Accuracy Guarantee: 99.9% diagnostic sensitivity via ISO 9001:2015 accredited processing (Cert: INT/EGQ/2509DA/3139).
- ✓Premium Logistics: VIP mobile phlebotomy with temperature-controlled cold-chain home collection available daily 8 AM – 11 PM.
- ✓Clinical Guidance: Telephonic post-test genetic counseling for result interpretation and family planning.
- ✓Insurance: Direct billing verification via WhatsApp +971 54 548 8731.
- ✓DHA Licensed: Facility License No. 1143, Dubai Healthcare City.
Test Overview & Methodology
This next-generation sequencing (NGS) test analyzes the entire coding region of the TPM2 gene to detect pathogenic mutations responsible for distal arthrogryposis type 1A — a congenital condition characterized by non-progressive joint contractures primarily of the hands and feet. The test is performed on peripheral whole blood samples and provides definitive molecular confirmation to support clinical diagnosis, genetic counseling, and family planning decisions.
| Feature | Our Test – TPM2 NGS | Closest Alternative (Sanger) |
|---|---|---|
| Methodology | NGS – full coding region | Sanger – selected exons only |
| Sensitivity | 99.9% | ~95% |
| Turnaround Time | 3–4 weeks | 6–8 weeks |
| Cost (UAE) | 2,800 AED | 4,500+ AED |
| ISO Accreditation | ISO 9001:2015 (INT/EGQ/2509DA/3139) | Variable |
Referred by: Consultant Medical Geneticist, Pediatric Orthopedic Surgeon, or Clinical Geneticist.
Pre-Test Requirement
A genetic counseling session to construct a detailed three-generation family pedigree is mandatory before sample collection. This ensures accurate interpretation of inheritance patterns and informed consent.
Physician Insight & Safety Protocols
“As a Consultant Medical Genetics, I emphasize that TPM2 gene sequencing results must be correlated with clinical examination and family history. This test provides molecular confirmation for distal arthrogryposis type 1A but does not predict disease severity or progression. Pre- and post-test genetic counseling with a board-certified genetic counselor is strongly recommended. A negative result does not exclude all genetic causes of arthrogryposis, and multidisciplinary follow-up with orthopedics and physiotherapy remains essential.”
— Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Advisory on Genetic Testing
This test should only be performed after a formal genetics consultation. Individuals with a known family history of distal arthrogryposis or unexplained congenital joint contractures are candidates. Results are confidential and protected under UAE data privacy law. A detailed family pedigree and informed consent documentation are required prior to sample collection. Discuss all reproductive implications with your genetic counselor before testing.
Exclusion Criteria
- Not suitable for individuals who cannot provide informed consent or have a bleeding disorder contraindicating venipuncture.
- If you experience sudden worsening of joint contractures, severe pain, or breathing difficulties, seek emergency medical care immediately.
- This molecular test does not replace emergency clinical evaluation; always consult your primary physician for new or worsening symptoms.
Patient FAQ & Clinical Guidance
1. What is the purpose of the TPM2 gene test?
This NGS-based test detects pathogenic mutations in the TPM2 gene responsible for distal arthrogryposis type 1A. It confirms clinical suspicion, enables targeted genetic counseling, supports family planning decisions, and helps differentiate from other forms of arthrogryposis. The report is generated under ISO-certified laboratory conditions ensuring diagnostic accuracy and reliability.
2. How should I prepare for the TPM2 genetic test?
No special fasting is required. A mandatory genetic counseling session to construct your family pedigree must be completed prior to sample collection. Please bring any previous genetic or orthopedic reports and inform the phlebotomist of all medications and supplements. Our VIP mobile phlebotomy service operates daily from 8 AM to 11 PM across Dubai and the Northern Emirates.
3. Who should consider taking this TPM2 DNA test?
Individuals with a personal or family history of distal arthrogryposis, unexplained congenital joint contractures, or a known TPM2 mutation in a first-degree relative should consider testing. Adults planning a family who carry a TPM2 mutation or have affected children also benefit from this analysis. Our team provides confidential pre- and post-test genetic counseling.
4. What does a positive test result mean?
A positive result confirms the presence of a pathogenic mutation in the TPM2 gene associated with distal arthrogryposis type 1A. It does not predict the severity of joint contractures or disease progression. Genetic counseling is essential to understand inheritance patterns, recurrence risks, and implications for family members. A positive result should always be interpreted alongside clinical evaluation by a medical geneticist.
5. Can genetic testing be performed on children?
Yes, with appropriate informed consent from a parent or legal guardian. Genetic testing in minors is performed only when the result directly impacts clinical management or family planning. Pre-test genetic counseling for the family is mandatory. The test uses a standard blood draw and carries minimal risk.
UAE Regulatory & Data Privacy Adherence
Data Privacy & Clinical Safety Compliance
DNA Labs UAE operates in full compliance with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) ensuring that all genetic and personal data are processed lawfully, stored securely, and never shared without explicit patient consent. Health information handling adheres to Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields, guaranteeing secure electronic health records and telemedicine practices. Clinical safety, patient consent, and medical liability are governed by Federal Decree-Law No. 4 of 2016 on Medical Liability, ensuring that all genetic testing procedures meet the highest standards of care. Our DHA-licensed laboratory (Facility License No. 1143) undergoes regular inspections and maintains ISO 9001:2015 certification for quality management.
Clinical & Logistical Metadata
| Test Name | TPM2 Gene Sequencing – Distal Arthrogryposis Type 1A |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3–4 weeks from sample receipt |
| Sample Type / Matrix | Peripheral whole blood (EDTA tube) – VIP mobile phlebotomy available daily 8 AM – 11 PM |
| Methodology Used | Next-Generation Sequencing (NGS) – full coding region analysis |
| ICD-10-CM Code | Q74.3 |
| LOINC Code | 21636-6 |
| DHA Facility License & Lab Address | License No. 1143 – Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE – DNA Labs UAE |
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