Test Price
2,800 AEDโ Home Collection Available
๐ Results in 3โ4 Weeks
TCN2 Gene (Transcobalamin II Deficiency) Genetic Test in UAE | 2,800 AED | DHA Licensed
Executive Summary & Core Metrics
- Diagnostic Precision: 99.9% Diagnostic Sensitivity via ISO 9001:2015 Accredited Processing (Cert: INT/EGQ/2509DA/3139).
- Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection โ Available daily from 8 AM to 11 PM.
- Clinical Guidance: Post-Test Telephonic Clinical Guidance for result interpretation by a DHA-licensed Consultant Medical Geneticist.
- Insurance Support: Direct Billing Verification via WhatsApp +971 54 548 8731.
Test Overview & Methodology
The TCN2 gene test utilizes Next-Generation Sequencing (NGS) to detect pathogenic variants in the Transcobalamin II gene, a critical transporter of vitamin Bโโ. This test provides definitive diagnosis for Transcobalamin II deficiency, an autosomal recessive metabolic disorder, enabling early intervention and personalized management.
| Feature | Our Test (NGS) | Standard Single-Gene Sanger |
|---|---|---|
| Methodology | Next-Generation Sequencing (full gene coverage) | Sanger sequencing (targeted regions only) |
| Analytical Sensitivity | >99.9% (SNVs, indels, CNVs) | ~98% (limited to predefined amplicons) |
| Turnaround Time | 3โ4 Weeks (UAE referral lab) | 6โ8 Weeks (often outsourced internationally) |
Physician Insight & Safety Protocols
Clinical Note from Ms. Lina Osama Zaki Quteineh (DHA Registration ID: 9294403, Consultant Medical Genetics): "A positive test should always be correlated with biochemical markers such as elevated methylmalonic acid and homocysteine levels, and with clinical presentation. Genetic counselling is mandatory before testing to interpret variants in the context of family history and consanguinity."
โ ๏ธ Medication & Urgent Care Advisory
Do not discontinue prescribed medication (including vitamin Bโโ injections) without consulting your doctor.
Exclusion Criteria: This test should not be ordered as a standalone screening tool in asymptomatic individuals without a positive family history or clinical indication.
Emergency Red Flags: If you experience severe pallor, tachycardia, shortness of breath, or neurological symptoms (confusion, numbness), seek immediate medical attention. These may indicate decompensated anemia or metabolic crisis.
Patient FAQ & Clinical Guidance
1. What does the TCN2 gene test diagnose?
The TCN2 gene test identifies inherited pathogenic variants causing Transcobalamin II deficiency, a treatable genetic disorder of vitamin Bโโ transport. Early diagnosis through NGS enables timely intervention with hydroxocobalamin therapy and prevents irreversible neurological damage.
2. How long does it take to receive results in the UAE?
Our accredited NGS workflow delivers a comprehensive clinical report within 3 to 4 weeks, including genetic counselling interpretation and DHA-compliant documentation. The report details all detected variants, their pathogenicity classification, and clinical recommendations.
3. Is home sample collection available, and what sample types are accepted?
Yes, ISO-certified VIP mobile phlebotomy is available daily from 8 AM to 11 PM for blood samples (whole blood in EDTA tube) or extracted DNA samples. A single dried blood spot on an FTA card is also accepted. All samples are transported via temperature-controlled cold-chain logistics.
UAE Regulatory & Data Privacy Adherence
All genetic testing and patient data handling at DNA Labs UAE comply with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Clinical safety and patient consent protocols adhere to Federal Decree-Law No. 4 of 2016 on Medical Liability. Your genetic data remains confidential, encrypted, and accessible only to authorized healthcare providers directly involved in your care.
Clinical & Logistical Metadata
| Test Name | TCN2 Gene (Transcobalamin II Deficiency) Genetic Test |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3โ4 Weeks |
| Sample Type / Matrix | Whole Blood (EDTA), Extracted DNA, or Dried Blood Spot (FTA Card) |
| Methodology Used | Next-Generation Sequencing (NGS) โ Full Gene Coverage |
| ICD-10-CM Code | E53.8 |
| LOINC Code | 81247-9 |
| DHA Facility License & Laboratory Address | DHA Facility License: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | Corporate Lab: DNA Labs UAE |
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Available in Arabic, English, Hindi & Urdu
Preparation Required
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Medically Reviewed by Dr. Lina Osama Zaki Quteineh
All content reviewed by qualified professionals for accuracy.
ISMS 27001:2022
ISO Accredited
HIPAA
All reports reviewed by DHA-Certified physicians