Test Price
2,800 AED✅ Home Collection Available
SERAC1 Gene Sequencing Test for 3‑Methylglutaconic Aciduria with Deafness, Encephalopathy, and Leigh‑like Syndrome (MEGDEL) in UAE | 2,800 AED | DHA-Registered
Executive Summary & Core Metrics
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Diagnostic Accuracy: 99.9% Sensitivity via ISO-accredited NGS processing, validated against international genetic databases.
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Premium Home Collection: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection (Available daily from 8 AM to 11 PM).
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Clinical Guidance: Complimentary telephonic post-test consultation explaining your result and next steps.
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Insurance: Direct billing verification via WhatsApp +971 54 548 8731 before your appointment.
Test Overview & Methodology
This advanced genetic test analyses the entire SERAC1 gene to detect pathogenic variants causing 3‑methylglutaconic aciduria with deafness, encephalopathy, and Leigh‑like syndrome (MEGDEL). The diagnosis guides precise clinical management and family planning.
| Feature | Our Test (SERAC1 NGS) | Closest Alternative |
|---|---|---|
| Precision | Full‑gene sequencing with single‑nucleotide and copy‑number variant detection | Targeted mutation panel (may miss novel variants) |
| Methodology | NGS (Illumina NovaSeq), clinically validated per CAP/UKAS standards | Sanger sequencing (gene‑by‑gene, slower) |
| Turnaround Time | 3‑4 Weeks | 6‑8 Weeks |
Physician Insight & Safety Protocols
Lina Osama Zaki Quteineh (Consultant Medical Genetics, DHA ID: 9294403)
“Interpreting a SERAC1 variant requires careful correlation with the patient’s clinical presentation, neuroimaging findings, and metabolic profile. A negative sequencing result does not entirely exclude the syndrome if clinical suspicion remains high, and further mitochondrial work‑up is often indicated. I strongly recommend discussing all findings with a referring metabolic specialist or clinical geneticist.”
Medication Advisory
Do not discontinue any prescribed medication without consulting your physician. Abrupt cessation of anti‑epileptics or mitochondrial cofactors can trigger metabolic crises.
Exclusion Criteria & Emergency Red Flags
This test is not suitable for individuals without a clinical suspicion of MEGDEL syndrome. A pre‑test genetic counselling session is mandatory and is included in the service.
Seek emergency care immediately if you or a family member experience:
- Sudden loss of consciousness or seizures
- Rapid neurological deterioration (loss of motor skills, vision changes)
- Severe metabolic acidosis symptoms (deep, rapid breathing; extreme lethargy)
- Unexplained hearing loss with developmental regression
Patient FAQ & Clinical Guidance
1. What does a positive SERAC1 gene result mean for my child?
A positive result confirms a molecular diagnosis of 3‑methylglutaconic aciduria with deafness, encephalopathy, and Leigh‑like syndrome (MEGDEL). It identifies the specific genetic change responsible for the condition, allowing your specialist to predict disease progression, recommend appropriate mitochondrial cocktail therapies, and screen at‑risk relatives.
2. How accurate is this test compared to older methods?
With 99.9% sensitivity and full‑gene coverage, NGS outperforms older single‑gene Sanger sequencing by detecting large deletions, duplications, and deep intronic variants. Our ISO‑accredited laboratory uses clinically validated NGS platforms that meet CAP/CLIA standards, ensuring results you can trust.
3. Is home collection available and safe for my sample?
Yes, our paid hospital‑grade home collection uses ISO‑certified cold‑chain logistics, guaranteeing DNA stability from venipuncture to laboratory processing. A trained phlebotomist arrives at your doorstep between 8 AM and 11 PM daily. You may also store blood on an FTA card if preferred.
UAE Regulatory & Data Privacy Adherence
Data Privacy & Security: This service strictly adheres to the Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Your genetic data is encrypted, anonymized, and processed exclusively within the UAE regulatory framework.
Clinical Safety & Consent: All clinical testing protocols and patient consent procedures comply with Federal Decree-Law No. 4 of 2016 on Medical Liability, ensuring ethical standards and patient safety are maintained throughout the diagnostic pathway.
Clinical & Logistical Metadata
| Test Name | SERAC1 Full Gene Sequencing & MEGDEL Syndrome Analysis |
| Price (AED) | 2,800 |
| Turnaround Time | 3-4 Weeks |
| Sample Type / Matrix | Whole Blood (Peripheral) or Genomic DNA Extract |
| Methodology Used | Next-Generation Sequencing (NGS, Illumina NovaSeq) |
| ICD-10-CM Code | E71.1 |
| LOINC Code | 94222-1 |
| DHA Facility License & Laboratory Address | License: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | DNA Labs UAE |
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Available in Arabic, English, Hindi & Urdu
ISMS 27001:2022
ISO Accredited
HIPAA
All reports reviewed by DHA-Certified physicians