Test Price
2,800 AED✅ Home Collection Available
SERAC1 Gene 3‑Methylglutaconic Aciduria with Deafness, Encephalopathy, and Leigh‑like Syndrome Genetic Test in UAE | 2800 AED | 2026 DHA Guidelines
تحليل جين SERAC1 لمرض الحمض الميثيل جلوتاكونيك البولي المصحوب بالصمم والاعتلال الدماغي والمتلازمة الشبيهة بمتلازمة لي في الإمارات | 2800 درهم | معتمد من هيئة الصحة بدبي
Executive Summary – ملخص تنفيذي
يقدم هذا التحليل الجيني الشامل لجين SERAC1 تشخيصًا دقيقًا لمرض الحمض الميثيل جلوتاكونيك البولي المصحوب بالصمم والاعتلال الدماغي والمتلازمة الشبيهة بمتلازمة لي، وفق أعلى معايير هيئة الصحة بدبي وتقنيات التسلسل الجيني المتقدم.
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Diagnostic Accuracy: 99.9% Sensitivity via ISO-accredited NGS processing, validated against 2026 international genetic databases.
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Premium Home Collection: Paid hospital‑grade service with ISO‑certified cold‑chain transport; VIP mobile phlebotomy 8 AM‑11 PM across all emirates.
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Clinical Guidance: Complimentary telephonic post‑test consultation explaining your result and next steps.
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Insurance: Direct billing verification via WhatsApp +971 54 548 8731 before your appointment.
Overview
This advanced Genetic Test analyses the entire SERAC1 gene to detect pathogenic variants causing 3‑methylglutaconic aciduria with deafness, encephalopathy, and Leigh‑like syndrome (MEGDEL). The diagnosis guides precise clinical management and family planning. يقوم الاختبار بفحص الجين بالكامل لتحديد الطفرات المسببة للمرض وتوجيه العلاج.
| Feature | Our Test (SERAC1 NGS) | Closest Alternative |
|---|---|---|
| Precision | Full‑gene sequencing with single‑nucleotide & copy‑number variant detection | Targeted mutation panel (may miss novel variants) |
| Methodology | NGS (Illumina® NovaSeq™), clinically validated per CAP/UKAS standards | Sanger sequencing (gene‑by‑gene, slower) |
| Turnaround Time | 3‑4 Weeks | 6‑8 Weeks |
Physician Insight & Safety Protocol
Dr. PRABHAKAR REDDY (DHA License: 61713011)
“Interpreting a SERAC1 variant requires correlation with your child’s clinical picture, neuroimaging, and metabolic profile. A negative result does not exclude the diagnosis if symptoms are highly suggestive; further mitochondrial work‑up is often indicated. Please discuss all results with your referring metabolic specialist or clinical geneticist.”
⚠ Medication Warning
Do not discontinue any prescribed medication without consulting your physician. Abrupt cessation of anti‑epileptics or mitochondrial cofactors can trigger metabolic crises.
Exclusion Criteria & ER Red Flags
This test is not suitable for individuals without a clinical suspicion of MEGDEL syndrome. A pre‑test genetic counselling session is mandatory (included in the service).
Seek emergency care immediately if you experience:
- Sudden loss of consciousness or seizures
- Rapid neurological deterioration (loss of motor skills, vision change)
- Severe metabolic acidosis symptoms (deep, rapid breathing; extreme lethargy)
- Unexplained hearing loss with regression
Patient FAQ & Clinical Guidance
1. What does a positive SERAC1 gene result mean for my child?
Snippet: A positive SERAC1 NGS result confirms a molecular diagnosis of 3‑methylglutaconic aciduria with deafness, encephalopathy, and Leigh‑like syndrome (MEGDEL), enabling tailored metabolic management.
It identifies the specific genetic change responsible for the condition, allowing your specialist to predict disease progression, recommend appropriate mitochondrial cocktail therapies, and screen at‑risk relatives. النتيجة الإيجابية تؤكد التشخيص الجزيئي للمتلازمة وتساعد في توجيه العلاج الاستقلابي والاستشارة الوراثية.
2. How accurate is this compared to older methods?
Snippet: With 99.9% sensitivity and full‑gene coverage, NGS outperforms older single‑gene Sanger sequencing by detecting large deletions, duplications, and deep intronic variants.
Our ISO‑accredited laboratory uses clinically validated NGS platforms that meet 2026 CAP/CLIA standards, ensuring results you can trust. دقة الاختبار تتجاوز 99.9٪ ويغطي الجين بالكامل، متفوقًا على الطرق التقليدية.
3. Is home collection available and safe for my sample?
Snippet: Our paid hospital‑grade home collection uses ISO‑certified cold‑chain logistics, guaranteeing DNA stability from venipuncture to laboratory processing within the same day.
A trained phlebotomist arrives at your doorstep between 8 AM and 11 PM. You can store blood on an FTA card if preferred. خدمة السحب المنزلي متاحة وآمنة مع سلسلة تبريد معتمدة لنقل العينة.
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التحقق من التغطية التأمينية
Check Insurance Coverage Instantly
Stop the guesswork. Send a photo of your Insurance Card and Doctor's Prescription to our DHA-Certified Verification Team on WhatsApp.
توقف عن التخمين. أرسل صورة من بطاقة التأمين ووصفة الطبيب إلى فريق التحقق المعتمد من هيئة الصحة بدبي عبر الواتساب. احصل على تحديث الحالة في دقائق.
Available in Arabic, English, Hindi & Urdu
ISMS 27001:2022
ISO Accredited
HIPAA
All reports reviewed by DHA-Certified physicians