Test Price
2,800 AED✅ Home Collection Available
PRODH Gene (Hyperprolinemia Type 1) Genetic Test in UAE | 2,800 AED
Executive Summary & Core Metrics
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO-Certified Processing (ISO 9001:2015).
- Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection. Available daily from 8 AM to 11 PM.
- Clinical Guidance: Telephonic Post-Test Clinical Guidance for result interpretation.
- Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.
- All-Inclusive Price: 2,800 AED – covers collection, NGS analysis, genetic counseling, and final report.
Test Overview & Methodology
The PRODH gene test identifies pathogenic variants causing Hyperprolinemia Type 1, an inherited metabolic disorder that can lead to neurological complications if untreated. This Next-Generation Sequencing (NGS) analysis provides definitive diagnosis, carrier detection, and guidance for family planning. The test is performed on peripheral whole blood or DNA FTA cards, with full gene coverage including all exons and flanking intronic regions.
Our Test vs. Closest Alternative
| Parameter | Our Test (PRODH NGS) | Biochemical Proline + Limited Mutation Panel |
|---|---|---|
| Diagnostic Method | Full Gene Next-Generation Sequencing | Plasma proline quantification & targeted mutation analysis |
| Variant Detection | All pathogenic, likely pathogenic, and VUS | Only known common mutations |
| Turnaround Time | 3–4 Weeks | 1–2 Weeks (biochemical) + 4–6 weeks for limited DNA |
| Price | 2,800 AED (all-inclusive) | Often fragmented costs; genetic component may exceed 3,500 AED |
| Clinical Utility | Definitive diagnosis, carrier screening, family planning | Preliminary diagnosis; may miss rare variants |
Physician Insight & Safety Protocols
“Understanding the implications of a genetic test result requires context from family history and clinical presentation. Even a positive finding does not always predict disease severity. I strongly recommend discussing this test with a certified genetic counselor beforehand to make an informed decision about your health and that of your relatives.”
— Lina Osama Zaki Quteineh | Consultant Medical Genetics | DHA Registration ID: 9294403
Medication Advisory
Do Not Stop Prescribed Medications
This test is not a substitute for ongoing clinical management. Continue all treatments unless your physician instructs otherwise. Any changes to medication should be made under direct medical supervision.
Safety Exclusion Criteria & Red Flags
- Exclusion: Pregnant individuals without a specific clinical indication approved by a geneticist; minors without documented parental consent as per UAE Federal Law No. 2 of 2019 (Health Data Protection).
- Exclusion: Sampling during acute critical illness (e.g., septic shock, acute metabolic crisis) may be deferred until stabilization.
- Red Flag: Seek immediate emergency care if you experience new-onset seizures, severe developmental regression, or sudden loss of consciousness—these may indicate severe hyperprolinemia requiring urgent intervention.
Patient FAQ & Clinical Guidance
1. What is the PRODH gene and why is it tested?
The PRODH gene encodes the enzyme proline dehydrogenase, which breaks down proline. Mutations cause hyperprolinemia type 1, a treatable inborn error of metabolism. Testing identifies disease-causing variants to confirm diagnosis, guide management (dietary restrictions, seizure control), and assess recurrence risks for family planning. Early detection through NGS allows proactive intervention, often preventing neurological deterioration.
2. How is the sample collected and what preparation is required?
Sample collection is a standard peripheral blood draw or a buccal swab (FTA card) performed by our VIP Mobile Phlebotomy team at your home or office (8 AM – 11 PM). A mandatory pre-test genetic counseling session (online or phone) documents your family pedigree. No fasting or medication adjustments are needed unless directed by your doctor.
3. What do the results mean and when will I receive them?
Results are delivered within 3–4 weeks from sample receipt. A positive result identifies a pathogenic variant confirming hyperprolinemia type 1; a negative result does not exclude other metabolic disorders. You will receive a detailed report and a telephonic consultation with a genetic specialist to explain the findings and recommend next steps. All data is secured under UAE data protection laws.
4. Is home collection available for this test?
Yes, because the specimen is peripheral whole blood or a buccal swab, we offer VIP Mobile Phlebotomy and Temperature-Controlled Cold-Chain Home Collection. Our team operates daily from 8 AM to 11 PM across all Emirates. This service is included in the all-inclusive price of 2,800 AED.
UAE Regulatory & Data Privacy Adherence
Your Privacy & Rights Protected Under UAE Law
- Data Protection: All genetic data is processed in compliance with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL).
- Health Data Security: The laboratory adheres to Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields, ensuring encrypted storage and limited access.
- Medical Liability: All clinical testing and patient consent procedures follow Federal Decree-Law No. 4 of 2016 on Medical Liability.
- DHA Licensing: This service is provided under DHA Facility License No. 1143, Dubai Healthcare City.
Clinical & Logistical Metadata
| Test Name | PRODH Gene (Hyperprolinemia Type 1) Genetic Test |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3–4 Weeks |
| Sample Type / Matrix | Whole Blood (Peripheral) or DNA FTA Card |
| Methodology Used | Next-Generation Sequencing (NGS) – Full Gene Analysis |
| ICD-10-CM Code | E72.59 |
| LOINC Code | 83512-6 |
| DHA Facility License & Laboratory Address | DHA License No. 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE – DNA Labs UAE |
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