Test Price
2,800 AED✅ Home Collection Available
POLG Gene Neuropathy with Sensory Ataxic Dysarthria and Ophthalmoparesis Genetic Test in UAE | 2800 AED | DHA Compliant
Executive Summary & Core Metrics
- Diagnostic Accuracy: 99.9% sensitivity via ISO‑accredited NGS processing.
- Premium Logistics: VIP Mobile Phlebotomy & Temperature‑Controlled Cold‑Chain Home Collection (available daily 8 AM to 11 PM).
- Post‑Test Support: Complimentary telephonic guidance for result interpretation.
- Insurance: Direct billing verification via WhatsApp +971 54 548 8731.
Test Overview & Methodology
This NGS‑based test sequences the entire POLG gene to identify pathogenic variants causing the mitochondrial syndrome of sensory ataxic neuropathy, dysarthria, and ophthalmoparesis (SANDO). The analysis covers single‑nucleotide variants, indels, and copy‑number changes across all coding regions and flanking intronic boundaries.
| Feature | Our Test (NGS Full Gene Sequencing) | Closest Alternative (Targeted Panel) |
|---|---|---|
| Precision | Single‑nucleotide variants, indels, copy‑number changes across entire POLG coding region | Limited to pre‑selected hotspots; may miss novel mutations |
| Methodology | NGS (Illumina) with advanced bioinformatics, DHA‑approved | PCR‑based or Sanger sequencing of selected exons |
| Turnaround Time | 3–4 weeks, report with clinical interpretation | 2–3 weeks but lower diagnostic yield |
| Compliance | ISO 9001:2015, UAE PDPL, Federal Decree‑Law No. 45 of 2021, Federal Law No. 2 of 2019 | May not carry UAE‑specific accreditation |
Physician Insight & Safety Protocols
“As a Consultant Medical Genetics, I understand the uncertainty that comes with progressive neurological symptoms. This POLG gene test offers a definitive molecular diagnosis, but the final clinical picture must always be interpreted together with a neurologist. Please do not stop any prescribed therapy without consulting your treating physician.”
— Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA ID: 9294403
Medication Advisory
⚠️ Medication Warning: Do not discontinue or adjust prescribed medication without your doctor’s direct supervision.
Exclusion Criteria & Emergency Red Flags
- Not recommended if you have an active systemic infection or severe coagulopathy without medical clearance.
- For individuals under 18: written parental consent and a mandatory pediatric genetic counselling session are required.
- Red flag symptoms prompting immediate ER visit: acute vision loss, sudden inability to speak or swallow, new‑onset respiratory distress.
Patient FAQ & Clinical Guidance
1. What does the POLG gene neuropathy NGS test detect?
This comprehensive NGS test detects pathogenic variants across the entire POLG gene, pinpointing mutations responsible for sensory ataxic neuropathy, dysarthria, and ophthalmoparesis (SANDO syndrome). The analysis includes single‑nucleotide changes, insertions/deletions, and copy‑number variations.
2. How is the test performed and what sample is needed?
A standard whole blood sample (EDTA tube) or extracted DNA is required. Our certified phlebotomist performs the collection at your home via VIP Mobile Phlebotomy service, using temperature‑controlled cold‑chain packaging to ensure sample integrity.
3. How long do results take and what do they mean?
Results are delivered within 3 to 4 weeks. The detailed genetic report includes variant classification, clinical interpretation, and guidance for follow‑up with a neurologist. A free telephonic consultation is provided to help you understand the findings.
UAE Regulatory & Data Privacy Adherence
DNA Labs UAE operates in full compliance with Federal Decree‑Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. All clinical testing safety and patient consent procedures adhere to Federal Decree‑Law No. 4 of 2016 on Medical Liability. Your genetic data is encrypted, stored within the UAE, and never shared without explicit consent.
Clinical & Logistical Metadata
| Test Name | POLG Gene Neuropathy with Sensory Ataxic Dysarthria and Ophthalmoparesis (SANDO) Genetic Test |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3–4 Weeks |
| Sample Type / Matrix | Whole Blood (EDTA) or Extracted DNA |
| Methodology Used | NGS Full Gene Sequencing (Illumina) |
| ICD-10-CM Code | G60.0, G31.81 |
| LOINC Code | 50397-9 |
| DHA Facility License & Laboratory Address | License: 1143 Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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