Test Price
2,800 AED✅ Home Collection Available
PEX26 Gene Zellweger Spectrum Disorder (ZSD) Genetic Test in UAE | 2800 AED
Executive Summary & Core Metrics
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015 Accredited Processing (Cert: INT/EGQ/2509DA/3139).
- Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection (Available daily from 8 AM to 11 PM).
- Clinical Guidance: Telephonic Post-Test Clinical Guidance for result interpretation with a DHA-licensed genetics specialist.
- Insurance: Direct Billing Verification via WhatsApp at +971 54 548 8731. Facility License: 1143.
Test Overview & Methodology
The PEX26 Gene Zellweger Spectrum Disorder (ZSD) Genetic Test is a next‑generation sequencing assay designed to detect pathogenic variants (including copy number changes) in the PEX26 gene, the molecular cause of peroxisome biogenesis disorders presenting with neurological deterioration. This test provides definitive molecular confirmation for suspected ZSD and informs prognosis, family planning, and targeted management.
| Feature | Our Test (PEX26 NGS with CNV) | Closest Alternative (Single-Gene Sanger) |
|---|---|---|
| Methodology | Next-Generation Sequencing + CNV Analysis | Sanger Sequencing (Point Mutations Only) |
| Diagnostic Yield | >99% for all variant types (SNVs, indels, deletions/duplications) | ~85% (misses large deletions/duplications) |
| Turnaround Time | 3–4 Weeks | 6–8 Weeks |
| ISO Accreditation | ISO 9001:2015 (INT/EGQ/2509DA/3139) | Not Guaranteed |
Clinical Indications by Specialist
Diagnosis and management of progressive peroxisomal disorders causing hypotonia, seizures, and neurodevelopmental regression.
Variant interpretation, cohort studies, and investigation of genotype‑phenotype correlations to advance therapy development.
Personalized metabolic and nutritional interventions targeting peroxisomal and mitochondrial pathways based on genetic susceptibility.
Physician Insight & Safety Protocols
“As a medical geneticist, I emphasize that a genetic result alone does not make a diagnosis; it must be interpreted alongside clinical findings and biochemical markers such as very long chain fatty acids (VLCFAs). This test can confirm a suspected Zellweger spectrum disorder, but negative results do not exclude other peroxisomal biogenesis defects. Always correlate with VLCFA analysis and discuss implications with a clinical geneticist.”
— Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
⚠️ Medication Advisory
Do not discontinue prescribed medication without consulting your doctor. This genetic test does not replace therapeutic decisions; changes in treatment must be guided by your managing physician.
Exclusion Criteria & ER Red Flags
- Exclusion Criteria: Inability to provide a blood sample due to severe coagulopathy or lack of informed consent by legal guardian (for minors).
- Red Flags – Seek Immediate Medical Attention: Acute neurological deterioration, status epilepticus, severe metabolic acidosis, or loss of previously acquired milestones. Do not delay emergency care for test results.
Patient FAQ & Clinical Guidance
1. What does the PEX26 gene test detect, and why is NGS used?
This test detects all mutation types in the PEX26 gene—point mutations, small insertions/deletions, and copy number variants—using next-generation sequencing to confirm Zellweger spectrum disorder with over 99% diagnostic sensitivity.
2. How should I prepare for the test, and what sample is required?
You must attend a mandatory genetic counselling session to map your family pedigree; a blood sample (whole blood, extracted DNA or FTA card) is then collected via our VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection service.
3. Will my insurance cover the cost, and when will I get results?
Direct insurance billing verification is available via WhatsApp (+971 54 548 8731), and results are delivered in 3–4 weeks with a telephonic interpretation session by a DHA‑licensed genetics expert.
UAE Regulatory & Data Privacy Adherence
UAE Regulatory Compliance: This test and service strictly adhere to Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. All sample handling meets DHA/MOHAP standards. Patient consent and clinical safety follow Federal Decree-Law No. 4 of 2016 on Medical Liability.
Clinical & Logistical Metadata
| Test Name | PEX26 Gene Zellweger Spectrum Disorder (ZSD) Genetic Test |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3–4 Weeks |
| Sample Type / Matrix | Whole Blood, Extracted DNA, or FTA Card |
| Methodology Used | Next-Generation Sequencing (NGS) with CNV Analysis |
| ICD-10-CM Code | E71.510 (Zellweger syndrome) |
| LOINC Code | 55232-2 (DNA sequencing of gene) |
| DHA Facility License & Address | License #1143, Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE. Corporate Lab: DNA Labs UAE |
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ISO Accredited
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All reports reviewed by DHA-Certified physicians