PCSK1 Gene Obesity with Impaired Prohormone Processing Genetic Test
Test Price
2,800 AEDโ Home Collection Available
PCSK1 Gene Obesity with Impaired Prohormone Processing Genetic Test in UAE | 2800 AED | DHA-Compliant Molecular Diagnosis
Executive Summary & Core Metrics
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity, confirmed by ISO 9001:2015 accredited NGS processing (Cert: INT/EGQ/2509DA/3139).
- Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection (Available daily from 8 AM to 11 PM).
- Clinical Guidance: Complimentary telephonic post-test clinical correlation session with a genetic counsellor to interpret your PCSK1 results.
- Insurance: Direct Billing Verification via WhatsApp at +971 54 548 8731.
Test Overview & Methodology
The PCSK1 Gene NGS test identifies pathogenic variants causing monogenic obesity due to impaired prohormone processing, a key step for early personalised treatment. The analysis covers all coding exons and splice junctions, identifying missense, nonsense, frameshift, and copy number variants that impair prohormone convertase 1/3 function.
| Feature | This Test (NGS) | Standard Sanger Sequencing |
|---|---|---|
| Diagnostic Precision | 99.9% Sensitivity (whole gene coverage, 100x depth) | Less than 95% (single exon focus, potential false negatives) |
| Methodology | Next Generation Sequencing (NGS), validated to DHA/MOHAP standards | Capillary Electrophoresis, limited to 1โ2 exons |
| Turnaround Time | 3 โ 4 Weeks | 4 โ 6 Weeks (often outsourced) |
| Clinical Utility | Full PCSK1 analysis, ready for DHA-approved reporting | Partial results, may require reflex to NGS |
Physician Insight & Safety Protocols
"I recognise the anxiety that genetic obesity brings to families. This test provides a molecular diagnosis that can end the diagnostic odyssey and guide precise therapy, but it must be interpreted in the full clinical context โ including growth charts and hormonal assays. Please involve your endocrinologist before making significant lifestyle or treatment changes." โ Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Medication Advisory
Do not discontinue prescribed medication without consulting your doctor. Genetic results are not a substitute for physician assessment. Always involve your treating specialist before making treatment decisions based on genetic findings.
Exclusion Criteria & Emergency Red Flags
- Exclusion Criteria: Patients with acute febrile illness (>38.5ยฐC), recent major surgery, or blood transfusion within 7 days.
- Exclusion Criteria: Individuals unable to provide valid informed consent (for minors, compliance with Federal Decree-Law No. 4 of 2016 on Medical Liability is mandatory).
- Red Flag: Seek immediate medical attention if you experience severe headache, visual disturbances, or chest pain during or after specimen collection.
Patient FAQ & Clinical Guidance
1. What is the PCSK1 gene obesity test and what does it detect?
This NGS test detects pathogenic mutations in the PCSK1 gene responsible for severe early-onset obesity, malabsorptive diarrhoea, and multiple endocrine abnormalities. The analysis covers all coding exons and splice junctions, identifying missense, nonsense, frameshift, and copy number variants that impair prohormone convertase 1/3 function.
2. How should I prepare for the test and what sample types are accepted?
No fasting is required; we accept whole blood, extracted DNA, or a single drop of blood on an FTA card for flexible collection. A genetic counselling session is recommended beforehand to draw a detailed pedigree chart of family members affected by PCSK1-related obesity. For UAE patients, a DHA-compliant referral form speeds up insurance verification.
3. What happens if a mutation is foundโwill my child's treatment change?
A positive result confirms monogenic obesity, guiding specific therapies like setmelanotide (if approved) and avoiding ineffective standard diet programmes. Our post-test clinical consultation explains the implications and connects you with an endocrinologist for personalised management, ensuring alignment with DHA protocols.
UAE Regulatory & Data Privacy Adherence
This service complies with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. All genetic data is processed under ISO 9001:2015 certified protocols, with strict access controls and encryption standards. Patient consent and clinical safety follow the provisions of Federal Decree-Law No. 4 of 2016 on Medical Liability.
Clinical & Logistical Metadata
| Test Name | PCSK1 Gene Obesity with Impaired Prohormone Processing Genetic Test |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3 โ 4 Weeks |
| Sample Type / Matrix | Whole Blood (EDTA), Extracted DNA, or Dried Blood Spot (FTA Card) |
| Methodology Used | Next Generation Sequencing (NGS) โ Whole Gene Coverage, 100x Depth |
| ICD-10-CM Code | E66.8 (Other Obesity), Z13.71 (Encounter for Genetic Testing) |
| LOINC Code | 94473-2 (PCSK1 gene full sequencing) |
| DHA Facility License & Address | DHA License No: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | DNA Labs UAE |
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Available in Arabic, English, Hindi & Urdu
โ๏ธ Medical Disclaimer
This test information is for educational purposes only and does not constitute medical advice. Results should be interpreted by a qualified healthcare professional. Always consult with a DHA-licensed physician for diagnosis and treatment decisions.
ISMS 27001:2022
ISO Accredited
HIPAA
All reports reviewed by DHA-Certified physicians