Test Price
2,800 AED✅ Home Collection Available
PCSK1 Gene Obesity with Impaired Prohormone Processing Genetic Test in UAE | 2800 AED | 2026 DHA Guidelines
تحليل جين PCSK1 للسمنة مع ضعف معالجة الهرمونات الأولية في الإمارات | 2800 درهم | معتمد من هيئة الصحة بدبي
Executive Summary / ملخص تنفيذي :
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity, confirmed by ISO 9001:2015 accredited NGS processing (Cert: INT/EGQ/2509DA/3139).
- Premium Logistics: Paid Hospital-Grade Home Collection with ISO Certified Cold-Chain Transportation, including VIP Mobile Phlebotomy (8 AM – 11 PM).
- Clinical Guidance: Complimentary telephonic post-test clinical correlation session with a genetic counsellor to interpret your PCSK1 results.
- Insurance: Direct Billing Verification via WhatsApp at +971 54 548 8731.
يقدم هذا الفحص الجيني الموثوق أعلى معايير الدقة لتشخيص السمنة الوراثية المرتبطة بجين PCSK1، مع خدمات سحب منزلي متميزة ودعم تأميني مباشر.
Overview
The PCSK1 Gene NGS test identifies pathogenic variants causing monogenic obesity due to impaired prohormone processing, a key step for early personalised treatment. يستخدم هذا الاختبار التسلسل الجيني لتشخيص السمنة الوراثية الناجمة عن خلل جين PCSK1، مما يوجه خطة العلاج الدقيقة.
| Feature | This Test (NGS) | Standard Sanger Sequencing |
|---|---|---|
| Diagnostic Precision | 99.9% Sensitivity (whole gene coverage, 100x depth) | <95% (single exon focus, potential false negatives) |
| Methodology | Next Generation Sequencing (NGS), validated to DHA/MOHAP standards | Capillary Electrophoresis, limited to 1-2 exons |
| Turnaround Time | 3 – 4 Weeks | 4 – 6 Weeks (often outsourced) |
| Clinical Utility | Full PCSK1 analysis, ready for DHA-approved reporting | Partial results, may require reflex to NGS |
Physician Insight & Safety Protocol
“I recognise the anxiety that genetic obesity brings to families. This test provides a molecular diagnosis that can end the diagnostic odyssey and guide precise therapy, but it must be interpreted in the full clinical context – including growth charts and hormonal assays. Please involve your endocrinologist before making significant lifestyle or treatment changes.” — Dr. PRABHAKAR REDDY, DHA License: 61713011
Medication Warning: Do not discontinue prescribed medication without consulting your doctor. Genetic results are not a substitute for physician assessment.
Exclusion Criteria & Emergency Red Flags
- Exclusion Criteria: Patients with acute febrile illness (>38.5°C), recent major surgery, or blood transfusion within 7 days.
- Exclusion Criteria: Individuals unable to provide valid informed consent (for minors, compliance with CDS Law 2026 is mandatory).
- Red Flag: Seek immediate medical attention if you experience severe headache, visual disturbances, or chest pain during or after specimen collection.
Patient FAQ & Clinical Guidance
What does the PCSK1 gene obesity test detect?
This NGS test detects pathogenic mutations in the PCSK1 gene responsible for severe early-onset obesity, malabsorptive diarrhoea, and multiple endocrine abnormalities. The analysis covers all coding exons and splice junctions, identifying missense, nonsense, frameshift, and copy number variants that impair prohormone convertase 1/3 function. يكشف هذا الفحص الطفرات المسببة للأمراض في جين PCSK1 التي تؤدي إلى السمنة الشديدة المبكرة وضعف معالجة الهرمونات.
How should I prepare for the test, and what samples are accepted?
No fasting is required; we accept whole blood, extracted DNA, or a single drop of blood on an FTA card for flexible collection. A genetic counselling session is recommended beforehand to draw a detailed pedigree chart of family members affected by PCSK1-related obesity. For UAE patients, a DHA-compliant referral form speeds up insurance verification. لا يتطلب الفحص صيامًا، ويمكن تقديم عينة دم كامل أو حمض نووي مستخلص أو قطرة دم على بطاقة FTA.
What happens if a mutation is found—will my child’s treatment change?
A positive result confirms monogenic obesity, guiding specific therapies like setmelanotide (if approved) and avoiding ineffective standard diet programmes. Our post- clinical consultation explains the implications and connects you with an endocrinologist for personalised management, ensuring alignment with 2026 DHA protocols. إذا كانت النتيجة إيجابية، فهذا يوجه العلاج الدقيق ويجنب الحميات غير الفعالة.
This service complies with Federal Decree-Law No. 41 of 2024 (Art. 87), Child Data Safeguarding Law 2026, and UAE PDPL. All data processed under ISO 9001:2015 certified protocols.
دعم ثنائي اللغة متاح
التحقق من التغطية التأمينية
Check Insurance Coverage Instantly
Stop the guesswork. Send a photo of your Insurance Card and Doctor's Prescription to our DHA-Certified Verification Team on WhatsApp.
توقف عن التخمين. أرسل صورة من بطاقة التأمين ووصفة الطبيب إلى فريق التحقق المعتمد من هيئة الصحة بدبي عبر الواتساب. احصل على تحديث الحالة في دقائق.
Available in Arabic, English, Hindi & Urdu
ISMS 27001:2022
ISO Accredited
HIPAA
All reports reviewed by DHA-Certified physicians