Test Price
2,800 AED✅ Home Collection Available
INSR Gene Diabetes Mellitus, Insulin-Resistant with Acanthosis Nigricans Genetic Test in UAE
Executive Summary & Core Metrics
- Diagnostic Accuracy: 99.9% analytical sensitivity achieved through ISO‑accredited next‑generation sequencing with full gene coverage and copy number variant analysis.
- Premium Logistics: VIP mobile phlebotomy with temperature‑controlled cold‑chain home collection, available daily from 8 AM to 11 PM.
- Post‑Test Clinical Guidance: Complimentary telephonic consultation with a consultant medical geneticist to interpret results in the context of your complete medical history.
- Insurance Verification: Direct coverage check via WhatsApp at +971545488731.
Test Overview & Methodology
This NGS‑based INSR gene test detects pathogenic and likely pathogenic variants in the insulin receptor gene, confirming monogenic severe insulin‑resistant diabetes mellitus and acanthosis nigricans with near‑perfect sensitivity. The assay utilises targeted enrichment followed by high‑depth sequencing and bioinformatic analysis for single‑nucleotide variants, insertions, deletions, and copy number variations.
| Parameter | Our Test | Closest Alternative |
|---|---|---|
| Precision | 99.9% analytical sensitivity (full gene coverage + CNV) | Single‑gene Sanger sequencing (~85% sensitivity) |
| Methodology | Next‑Generation Sequencing (NGS) with CNV analysis | Conventional Sanger sequencing with regulatory region gaps |
| Turnaround Time | 21–28 business days | 6–8 weeks |
Physician Insight & Safety Protocols
“As a consultant medical geneticist, I understand the anxiety that unexplained insulin resistance and acanthosis nigricans can cause. This comprehensive genetic test brings clarity, but results must always be correlated with your full clinical history and physical findings—never interpreted in isolation. I strongly encourage every patient to discuss the outcome with a qualified genetic counsellor to guide personalised management.”
— Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
⚠️ Important Safety Advisory
Do not stop or alter any prescribed insulin, metformin, or other diabetes medication without consulting your treating physician. Changing dosages without medical supervision may lead to severe hypoglycaemia, hyperglycaemia, or diabetic ketoacidosis. This genetic test is a diagnostic aid—it does not replace your current treatment plan.
Exclusion Criteria & Emergency Indicators
Exclusion Criteria
- Recent blood transfusion (within 4 weeks)
- Prior bone marrow transplantation
- Minor without legal guardian consent (per Federal Decree‑Law No. 45 of 2021 on Personal Data Protection)
Emergency Red Flags
- Severe hypoglycaemia (loss of consciousness, confusion, seizures)
- Diabetic ketoacidosis symptoms (nausea, vomiting, rapid deep breathing, fruity breath)
- Acute pancreatitis signs (severe upper abdominal pain radiating to the back)
If you experience any of these symptoms, proceed immediately to the nearest emergency department or call 998.
Patient FAQ & Clinical Guidance
1. What does a positive INSR gene test mean for my diabetes management?
A positive result confirms a monogenic form of severe insulin resistance, guiding targeted therapies beyond standard insulin or metformin protocols. Depending on the specific mutation, your endocrinologist may consider insulin‑sensitising agents, IGF‑1 therapy, or experimental treatments, while also screening family members for the same variant. All results are delivered with a genetic counsellor consultation to ensure appropriate clinical action.
2. How is the DNA sample collected for this test, and is home collection available?
Yes, our VIP mobile phlebotomy service collects a simple peripheral whole blood sample or a single drop on an FTA card at your home, office, or hotel. The collection is performed by trained nurses using ISO‑certified cold‑chain transport, and you receive real‑time tracking. No hospital visit is required. Service is available daily from 8 AM to 11 PM.
3. Can this test be performed on children, and what are the legal requirements?
Yes, testing can be performed on minors. Under Federal Decree‑Law No. 45 of 2021 on Personal Data Protection (PDPL), a parent or legal guardian must provide written informed consent, and a mandatory pre‑genetic counselling session is required. The paediatric sample is collected with extreme care by our specialist team, and results are disclosed only to the authorised guardian with a clinically actionable report.
4. How long does it take to receive the results, and how are they delivered?
The standard turnaround time is 21–28 business days from sample receipt at the laboratory. Results are delivered via a secure digital portal and include a detailed clinical report with variant classification, interpretation, and management recommendations. A telephonic consultation with a consultant medical geneticist is scheduled upon results release.
UAE Regulatory & Data Privacy Adherence
Your Data, Your Rights
DNA Labs UAE operates under the strictest data protection frameworks mandated by UAE federal law:
- Federal Decree‑Law No. 45 of 2021 on Personal Data Protection (PDPL) governs the collection, processing, storage, and transfer of your personal and genetic data. You have the right to access, rectify, and request deletion of your data at any time.
- Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields regulates the secure handling of electronic health records, ensuring confidentiality, integrity, and availability of your clinical information.
- Federal Decree‑Law No. 4 of 2016 on Medical Liability establishes the legal framework for informed consent and clinical safety, protecting your rights throughout the testing pathway.
All genetic data is encrypted, access‑controlled, and stored within the UAE. We do not share your data with third parties without your explicit written consent.
Clinical & Logistical Metadata
| Test Name | INSR Gene Diabetes Mellitus, Insulin-Resistant with Acanthosis Nigricans Genetic Test |
| Price (AED) | 2,800 AED |
| Turnaround Time | 21–28 Business Days |
| Sample Type / Matrix | Peripheral Whole Blood or FTA Card (Dried Blood Spot) |
| Methodology Used | Next-Generation Sequencing (NGS) with Copy Number Variation (CNV) Analysis |
| ICD-10-CM Code | E11.8 |
| LOINC Code | 21636-6 |
| DHA Facility License & Laboratory Address | DHA License No. 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | DNA Labs UAE |
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All reports reviewed by DHA-Certified physicians