Test Price
2,800 AED✅ Home Collection Available
HOXD13 Gene Syndactyly Type 5 Genetic Test – NGS Diagnostic Confirmation
DHA-ApprovedExecutive Summary & Core Metrics
Executive Summary: This advanced genetic test employs next-generation sequencing (NGS) to identify pathogenic variants in the HOXD13 gene associated with syndactyly type 5 (SD5), achieving diagnostic sensitivity exceeding 99.9% through an ISO-accredited laboratory process. The service includes VIP mobile phlebotomy with temperature-controlled cold-chain home collection, telephonic post-test clinical guidance, and direct billing verification via WhatsApp at +971 54 548 8731.
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO Accredited Processing.
- Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection (Available daily from 8 AM to 11 PM).
- Clinical Guidance: Telephonic Post-Test Clinical Guidance in result interpretation.
- Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.
Test Overview & Methodology
The HOXD13 Gene Syndactyly Type 5 Genetic Test utilizes next-generation sequencing to detect pathogenic variants in the HOXD13 gene, confirming a clinical diagnosis of syndactyly type 5 (SD5) and guiding family planning. This test is essential for pediatricians, clinical geneticists, and genetic counselors managing congenital limb malformations. The assay targets all coding exons and flanking intronic regions of HOXD13 with 100% coverage at 50x depth on the Illumina platform.
| Feature | Our Test | Closest Alternative |
|---|---|---|
| Precision | NGS with 100% coverage of HOXD13 coding regions | Sanger sequencing (single exon focus) |
| Methodology | Next-Generation Sequencing (Illumina platform, ISO validated) | Sanger sequencing |
| Turnaround Time | 3–4 weeks | 4–6 weeks |
Physician Insight & Safety Protocols
“As a consultant medical genetics specialist, I emphasize that a positive HOXD13 variant must be interpreted within the full context of clinical presentation and family pedigree. This test provides definitive molecular confirmation for syndactyly type 5, enabling accurate recurrence risk assessment and informed family planning decisions. It should complement, not replace, a thorough dysmorphology examination and pre-test genetic counseling.” — Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Safety Advisory & Clinical Precautions
⚠️ Critical Safety Information
Do not discontinue prescribed medication or alter clinical management without consulting your treating physician. This genetic test provides diagnostic information and does not replace ongoing medical supervision or surgical evaluation when indicated.
All clinical procedures adhere to Federal Decree-Law No. 4 of 2016 on Medical Liability, ensuring patient safety and informed consent standards are met prior to sample collection.
Exclusion Criteria & Emergency Red Flags
Safety Exclusion Criteria & Emergency Red Flags
- Exclusion: Inability to provide informed consent; severe coagulopathy; active skin infection at venipuncture site.
- Exclusion: Patient undergoing high-dose anticoagulant therapy (relative; discuss with physician before blood draw).
- Emergency Red Flag: If the affected limb develops sudden swelling, discoloration, or severe pain, seek immediate surgical evaluation — this test is not intended for acute crisis management.
Patient FAQ & Clinical Guidance
1. What is the HOXD13 gene test used for?
Direct Answer: This test identifies mutations in the HOXD13 gene to confirm a diagnosis of syndactyly type 5, a hereditary hand malformation characterized by fusion of fingers and toes.
It provides definitive molecular confirmation, enabling accurate genetic counseling and recurrence risk assessment for family members. The test is recommended when physical examination suggests SD5 and there is a positive family history of limb malformations.
2. How is the sample collected, and is it painful?
Direct Answer: A standard peripheral blood draw is performed by a trained phlebotomist using sterile technique. The procedure is minimally uncomfortable and typically completed within 10 minutes.
Our VIP mobile phlebotomy team follows strict temperature-controlled cold-chain protocols and can collect the sample at your home between 8 AM and 11 PM daily. No special preparation is needed beyond a pre-test genetic counseling session to document the family pedigree.
3. When will I receive my results, and what support is provided?
Direct Answer: Results are delivered within 3 to 4 weeks, accompanied by a telephonic consultation with a consultant medical geneticist.
We provide a comprehensive report explaining the genetic finding and its clinical implications, plus direct access to a genetic counselor to discuss next steps including surgical interventions, family planning, and recurrence risk for future pregnancies.
4. Is genetic counseling included with this test?
Direct Answer: Yes, pre-test and post-test genetic counseling is an integral component of this service.
A certified genetic counselor will discuss the implications of possible results, obtain informed consent, and after results are available, explain the molecular findings and coordinate any necessary referrals to orthopedic surgeons or other specialists.
UAE Regulatory & Data Privacy Adherence
Your data is protected under UAE law. All genetic information is handled in strict compliance with:
- Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) — governing the collection, processing, and storage of personal data.
- Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields — ensuring secure handling of electronic health records and genetic data.
Results are encrypted during transmission and stored on UAE-based servers with restricted access. No genetic data is shared with third parties without explicit patient consent.
Clinical & Logistical Metadata
| Test Name | HOXD13 Gene Syndactyly Type 5 Genetic Test (NGS) |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3–4 weeks |
| Sample Type / Matrix | Peripheral whole blood (EDTA tube) — VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection available daily from 8 AM to 11 PM |
| Methodology Used | Next-Generation Sequencing (Illumina platform, ISO 15189 accredited process) |
| ICD-10-CM Code | Q70.0 (Fused fingers), Q70.3 (Fused toes) |
| LOINC Code | 21636-6 (DNA sequencing for mutations) |
| DHA Facility License & Laboratory Address | License No. 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | DNA Labs UAE |
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ISMS 27001:2022
ISO Accredited
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