Test Price
2,800 AED✅ Home Collection Available
FMO3 Gene Trimethylaminuria Genetic Test in UAE | 2,800 AED | DHA Licensed Laboratory
Executive Summary & Core Metrics
- ✓Accuracy Guarantee: 99.9% Diagnostic Sensitivity achieved through ISO 9001:2015 accredited NGS processing and rigorous variant interpretation.
- ✓Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection available daily from 8 AM to 11 PM.
- ✓Clinical Guidance: Telephonic Post-Test Genetic Counseling provided by DHA-licensed genetics consultants for result interpretation.
- ✓Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731 – instant pre-approval for covered networks.
Test Overview & Methodology
The FMO3 Gene Trimethylaminuria Genetic Test is a definitive molecular investigation for the inherited metabolic disorder Trimethylaminuria (TMAU). By sequencing the entire coding region of the FMO3 gene, it identifies pathogenic variants responsible for impaired trimethylamine metabolism, providing clarity for affected individuals and their families. This test is the gold standard for confirming genetic trimethylaminuria and differentiating it from transient dietary or gut microbiome influences.
| Feature | Our Test (FMO3 NGS) | Alternative (Urine TMA/TMAO Ratio) |
|---|---|---|
| Method | Next-Generation Sequencing (NGS) – Full gene analysis | Biochemical urinary metabolite measurement |
| Diagnostic Sensitivity | 99.9% | ~70% (influenced by diet) |
| Turnaround Time | 3 – 4 Weeks | 1 – 2 Weeks |
| Clinical Utility | Carrier detection, family planning, confirmatory diagnosis | Screening only; cannot distinguish transient vs genetic forms |
Physician Insight & Safety Protocols
"The FMO3 gene sequencing test offers definitive molecular confirmation for trimethylaminuria, which is crucial for patients who have experienced years of misdiagnosis. I always emphasize that a positive genetic result should be correlated with urinary metabolite profiling and that comprehensive pre- and post-test genetic counselling is essential. Understanding the inheritance pattern and psychosocial impact is just as important as the genetic finding."
— Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA License No. 9294403
Advisory Information
Do not discontinue any prescribed medication without consulting your physician. Certain supplements such as choline and lecithin can influence trimethylamine levels and may interfere with test interpretation. Please discuss your current medications and supplements with your healthcare provider prior to testing.
Safety & Exclusion Information
- Exclusion Criteria: Individuals unable to provide informed consent as mandated by Federal Decree-Law No. 4 of 2016 on Medical Liability (including minors without a legal guardian). Active severe febrile illness may warrant rescheduling.
- Emergency Red Flags: Sudden, severe onset of fish-like body odor accompanied by confusion, vomiting, cyanosis, or acute liver dysfunction — seek immediate emergency medical care.
Patient FAQ & Clinical Guidance
1. What does a positive FMO3 genetic test mean?
A positive result confirms a genetic mutation in the FMO3 gene linked to trimethylaminuria, a metabolic disorder also known as fish odor syndrome. This indicates your body cannot efficiently break down trimethylamine, leading to the characteristic odor. The test cannot predict symptom severity, which varies widely among individuals. Clinical correlation with urinary metabolite analysis is recommended for comprehensive management.
2. How accurate is this NGS test for trimethylaminuria?
This next-generation sequencing test achieves 99.9% sensitivity in detecting pathogenic FMO3 gene variants. It covers the entire coding sequence and draws on validated bioinformatics pipelines. Unlike urine biochemical tests, it is not influenced by recent diet or choline intake, making it the most definitive genetic test available for trimethylaminuria.
3. Can this test be used for children?
Pediatric testing is permitted with parental or legal guardian consent in compliance with Federal Decree-Law No. 4 of 2016 on Medical Liability. A mandatory pre-test genetic counseling session is required to assess family history and obtain the necessary documentation. Sample collection for minors follows atraumatic protocols and can be arranged via our VIP Mobile Phlebotomy service.
UAE Regulatory & Data Privacy Adherence
Compliance Framework
This service strictly adheres to Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Genetic data is processed under an ISO 9001:2015 certified quality management system (Cert: INT/EGQ/2509DA/3139) and is never shared without explicit patient consent.
Clinical & Logistical Metadata
| Test Name | FMO3 Gene Trimethylaminuria Genetic Test |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3 – 4 Weeks |
| Sample Type / Matrix | Peripheral Whole Blood (EDTA) or Saliva |
| Methodology Used | Next-Generation Sequencing (NGS) – Full Gene Sequencing |
| ICD-10-CM Code | E88.89 |
| LOINC Code | 94137-0 |
| DHA Facility License & Laboratory Address | DHA License: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | DNA Labs UAE |
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