Test Price
2,800 AED✅ Home Collection Available
FBN1 Gene Sequencing Test (Ectopia Lentis, Familial) in UAE | 2800 AED
Executive Summary & Core Metrics
- Accuracy Guarantee: 99.9% diagnostic sensitivity via ISO 9001:2015 accredited next‑generation sequencing (NGS).
- Premium Logistics: VIP Mobile Phlebotomy & temperature‑controlled cold‑chain home collection, available daily from 8 AM to 11 PM.
- Clinical Guidance: Complimentary telephonic post‑test clinical guidance for result interpretation.
- Insurance: Direct billing verification via WhatsApp +971 54 548 8731.
Test Overview & Methodology
Comprehensive Genetic Insight for Familial Ectopia Lentis
The FBN1 gene sequencing test uses next‑generation sequencing (NGS) to identify pathogenic variants in the fibrillin‑1 gene responsible for isolated familial ectopia lentis and its syndromic forms, primarily Marfan syndrome. This comprehensive test covers all coding regions and flanking intronic boundaries, detecting single‑nucleotide variants, small insertions/deletions, and copy‑number variants through advanced bioinformatic analysis.
| Feature | Our Test – FBN1 NGS | Closest Alternative – Sanger Single‑Variant |
|---|---|---|
| Precision | Full‑gene coverage, all coding regions ±20 bp flanking introns; detects SNVs, indels, CNVs (via NGS advances) | Only targeted known familial mutation; misses novel or deep intronic variants |
| Methodology | Next‑Generation Sequencing (Illumina platform) with Sanger confirmation | Sanger sequencing of a single exon or mutation site |
| Reporting Speed | 3–4 weeks (comprehensive interpretative report) | 2–3 weeks (limited scope) |
| Diagnostic Yield | >98% for FBN1‑related disorders (enhanced by companion bioinformatics) | High only when family mutation is already known |
Physician Insight & Safety Protocols
A Note from Lina Osama Zaki Quteineh – Consultant Medical Genetics (DHA: 9294403)
“As a clinical geneticist practicing in the UAE, I recommend FBN1 genetic testing for any patient with unexplained lens dislocation or a family history suggestive of Marfan syndrome. This test provides clarity that guides not only ocular management but also life‑saving cardiovascular surveillance. Please remember, genetic results must always be correlated with a full clinical evaluation and discussed with a clinical geneticist.”
Advisory Warnings
Critical Medication Warning
Do not discontinue prescribed medication without consulting your doctor.
If you are taking blood thinners (e.g., warfarin, aspirin), please inform the phlebotomist before sample collection. Always follow your physician’s advice regarding any medication adjustment.
Exclusion Criteria & Emergency Red Flags
- Exclusion Criteria: Biologically unrelated individuals for a family‑specific test; patients unable to provide informed consent per Federal Decree‑Law No. 4 of 2016 on Medical Liability; minors without a legal guardian in accordance with UAE Personal Data Protection Law (Federal Decree‑Law No. 45 of 2021) and Medical Liability Law.
- Emergency Red Flags – Seek immediate medical attention if you experience: sudden severe chest pain, acute vision loss, intense headache, or signs of aortic dissection (sharp back pain, loss of pulse). These may indicate Marfan‑related emergencies and not a reaction to the blood draw.
Patient FAQ & Clinical Guidance
1. What is the purpose of the FBN1 gene sequencing test?
The test analyzes the entire FBN1 gene using next‑generation sequencing to identify mutations causing familial ectopia lentis and associated conditions like Marfan syndrome, enabling precise clinical management.
2. How is the test performed and what sample is required?
A blood sample, a single drop of blood on an FTA card, or previously extracted DNA can be submitted; our VIP home phlebotomy team collects the sample using cold‑chain logistics to guarantee DNA integrity.
3. How long does it take to receive the results and who interprets them?
Results are typically available within 3 to 4 weeks, including a detailed clinical report reviewed by our molecular geneticists; a post‑test teleconsultation with a clinical genetics expert is included.
UAE Regulatory & Data Privacy Adherence
Regulatory Compliance & Accreditation
Licensed by Dubai Health Authority (DHA) Facility License Number: 1143. All procedures comply with Federal Decree‑Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Laboratory operations are ISO 9001:2015 certified (Cert: INT/EGQ/2509DA/3139).
For insurance pre‑approval and appointment scheduling, WhatsApp +971 54 548 8731. Home collection is available daily from 8 AM to 11 PM.
Clinical & Logistical Metadata
| Test Name | FBN1 Gene Sequencing Test (Ectopia Lentis, Familial) |
| Price (AED) | 2,800 |
| Turnaround Time | 3–4 weeks |
| Sample Type / Matrix | Whole blood, FTA card, or extracted DNA; VIP Mobile Phlebotomy & cold‑chain home collection available daily 8 AM–11 PM |
| Methodology Used | Next‑Generation Sequencing (Illumina) with Sanger confirmation |
| ICD-10-CM Code | Q10.1 |
| LOINC Code | 97636-1 |
| DHA Facility License & Laboratory Address | DHA License 1143 – Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE. Corporate Lab: DNA Labs UAE |
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Available in Arabic, English, Hindi & Urdu
ISMS 27001:2022
ISO Accredited
HIPAA
All reports reviewed by DHA-Certified physicians