Test Price
2,800 AED✅ Home Collection Available
EGF Gene Hypomagnesemia Type 4 Genetic Test in UAE | 2800 AED | 2026 DHA Guidelines
تحليل جين EGF لنقص مغنيزيوم الدم من النوع الرابع بتقنية التسلسل الجيني (NGS) في الإمارات | 2800 درهم | معتمد من هيئة الصحة بدبي
Clinical Precision, UAE-Compliant Logistics
This advanced Next-Generation Sequencing (NGS) test analyzes the entire EGF gene for pathogenic variants causing Autosomal Dominant Hypomagnesemia Type 4 (isolated renal magnesium wasting). Performed at our ISO 9001:2015‑certified facility (Cert: INT/EGQ/2509DA/3139), we deliver 99.9% diagnostic sensitivity with a turnaround time of 3–4 weeks. UAE residents enjoy Hospital‑Grade Cold‑Chain Home Collection (8 AM–11 PM), VIP mobile phlebotomy, and telephonic post‑test clinical guidance. Direct insurance billing is verified instantly via WhatsApp at +971 54 548 8731.
ملخص تنفيذي طبي: يقدم فحص تسلسل الجين الكامل لـ EGF باستخدام تقنية الجيل التالي (NGS) للكشف عن الطفرات المسبّبة لنقص مغنيزيوم الدم الوراثي السائد من النوع الرابع (الضياع الكلوي المعزول للمغنيزيوم). بدقة تشخيصية تبلغ 99.9% وبمدة إنجاز تتراوح من 3 إلى 4 أسابيع، وفق معايير مختبرنا المعتمد ISO 9001:2015 (رقم الشهادة INT/EGQ/2509DA/3139). تشمل الخدمة سحب عينات منزلية بمستوى المستشفيات وسلسلة تبريد معتمدة على مدار الساعة، واستشارة طبية هاتفية بعد النتيجة، وتدقيق فوري لبطاقة التأمين الصحي عبر واتساب على الرقم +971 54 548 8731.
Clinical Intent & Specialist Guidance
This test is clinically indicated when a patient presents with unexplained hypomagnesemia, particularly with family history suggesting autosomal dominant inheritance. The following specialists are central to the diagnostic journey:
- General Physician / Internist – Initial recognition of refractory hypomagnesemia and referral for genetic workup.
- Clinical Geneticist – Interpretation of NGS data, variant classification, and genetic counselling with pedigree analysis.
- Nephrologist – Management of renal magnesium wasting, electrolyte correction, and long-term prevention of nephrocalcinosis.
Test Overview – Precision Meets Speed
The EGF Gene Hypomagnesemia Type 4 Genetic Test sequences the entire coding region and exon‑intron boundaries of the EGF gene using high‑coverage Next‑Generation Sequencing, enabling detection of single nucleotide variants, small insertions/deletions, and copy number variations with >99.9% analytical sensitivity. This test replaces older single‑gene Sanger approaches with a comprehensive, single‑tube workflow, delivering clinically actionable results in 3–4 weeks.
| Feature | Our Test (NGS) | Closest Alternative (Sanger Sequencing) |
|---|---|---|
| Methodology | Next‑Generation Sequencing (NGS) | Sanger sequencing of coding exons |
| Detection Range | Full gene (SNVs, indels, CNVs) | Limited to targeted amplicons; CNVs missed |
| Turnaround Time | 3–4 weeks | 4–6 weeks (multiple reactions) |
| Diagnostic Yield | 99.9% analytical sensitivity | ~95% for point mutations |
| Sample Requirement | Whole blood, extracted DNA, or one drop on FTA card | High‑quality DNA (blood only) |
Physician Insight & Safety Protocol
Dr. Prabhakar Reddy, DHA License 61713011, says: “I understand that testing for a rare genetic condition can cause anxiety. This test accurately identifies EGF gene mutations, but a negative result does not exclude all forms of hypomagnesemia. Always correlate the result with serum magnesium, urinary magnesium, and clinical presentation. This information is a piece of the puzzle, not a standalone diagnosis.”
⚠️ Important Medication Warning: Do not discontinue any prescribed medication, especially magnesium supplements or diuretics, without consulting your treating physician. Abrupt changes can trigger severe arrhythmias or tetany.
Exclusion Criteria & Emergency Red Flags
- Pregnancy or breastfeeding (test deferred unless urgently indicated).
- Recent blood transfusion or allogeneic bone marrow transplant (samples within 6 weeks may yield non‑representative DNA).
- Actively symptomatic severe hypomagnesemia: immediate medical attention required before elective testing.
🚨 If you experience sudden muscle cramps, seizures, confusion, or palpitations – proceed to the nearest Emergency Room immediately. Do not wait for genetic test results.
Before Your Test – Essential Logistics
- Mandatory Genetic Counselling: A pre‑test session with a certified genetic counsellor is required to draw a detailed pedigree chart of family members affected by hypomagnesemia type 4.
- Sample Options: We accept whole blood (3‑5 mL in EDTA tube), extracted DNA (≥1 µg), or one drop of blood on an FTA card. Our mobile phlebotomist will advise during home collection.
- Medication/Supplement Guidance: Discontinue magnesium-containing supplements for 24 hours before sampling. Inform the team about all prescription medications (especially proton‑pump inhibitors, diuretics) as they may influence magnesium levels but do not affect the genetic result.
- Fasting: Not required. However, maintain adequate hydration.
- Turnaround Time: Results are reported in 3–4 weeks. Rush processing is not available to maintain the highest quality standards.
UAE Regulatory & Quality Commitments
All genetic data is stored on encrypted servers within the UAE, in full compliance with Personal Data Protection Law. Patient identity protection is guaranteed; only authorized clinicians access identifiable reports.
Frequently Asked Questions
Q1. What is the EGF Gene Hypomagnesemia Type 4 Genetic Test?
Direct Answer: It is a comprehensive Next‑Generation Sequencing test that analyzes the full EGF gene to identify mutations causing autosomal dominant isolated renal magnesium wasting, aiding in accurate diagnosis and family screening.
الفحص الشامل بتقنية التسلسل الجيني للجيل التالي لجين EGF يُحلل الجين بأكمله لاكتشاف الطفرات المسؤولة عن الضياع الكلوي المعزول للمغنيزيوم، مما يسهم في التشخيص الدقيق وفحص أفراد الأسرة.
Q2. How accurate is this Genetic Test and when should I expect results?
Direct Answer: The achieves 99.9% analytical sensitivity for single nucleotide variants and small insertions/deletions, with results delivered in 3 to 4 weeks from sample receipt at our ISO‑certified laboratory.
تبلغ الحساسية التحليلية 99.9% للطفرات النقطية والإدخالات/الحذف الصغيرة، وتصدر النتائج خلال 3 إلى 4 أسابيع من استلام العينة في مختبرنا المعتمد ISO.
Q3. What sample is required and is home collection available across the UAE?
Direct Answer: We accept whole blood, extracted DNA, or a single drop on an FTA card; hospital‑grade cold‑chain home collection is provided throughout the UAE from 8 AM to 11 PM, including weekends.
نقبل الدم الكامل أو الحمض النووي المستخلص أو قطرة واحدة على بطاقة FTA، وتتوفر خدمة السحب المنزلي بمستوى المستشفيات وسلسلة تبريد في الإمارات من 8 صباحاً إلى 11 مساءً.
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