Test Price
2,800 AED✅ Home Collection Available
COL4A4 Alport Syndrome Autosomal Recessive Genetic Test in UAE | 2800 AED | 2026 DHA Guidelines
تحليل جين COL4A4 لمتلازمة ألبورت الصبغية المتنحية عبر التسلسل الجيني (NGS) في الإمارات | 2800 درهم | معتمد من هيئة الصحة بدبي
Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO Accredited NGS Processing on Illumina NovaSeq™.
Premium Logistics: Paid Hospital-Grade Home Collection – ISO-Certified Cold-Chain Phlebotomy for Blood, Extracted DNA, or FTA Card.
Clinical Guidance: Telephonic Post‑Test Interpretation included; pre‑test genetic counselling session to draw pedigree chart available.
Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.
Comprehensive COL4A4 Gene Analysis – Overview
Next-generation sequencing of the COL4A4 gene provides a definitive molecular diagnosis for autosomal recessive Alport syndrome, revealing pathogenic mutations that cause sensorineural hearing loss, progressive kidney disease, and ocular defects. يُعد هذا الفحص المرجعي الذهبي لتأكيد التشخيص وتوجيه خطة المراقبة والعلاج للمرضى في الإمارات.
| Feature | Our COL4A4 NGS Test | Closest Alternative (Exome Sequencing) |
|---|---|---|
| Precision | Full COL4A4 gene coverage, deep intronic & splice-site variants, 99.9% sensitivity | Whole‑exome; may miss regulatory variants; ~95% sensitivity for known regions |
| Method | Illumina NovaSeq™ NGS + Sanger confirmation + bioinformatic pathogenicity scoring | Exome capture + NGS, no targeted validation for COL4A4 |
| Turnaround | 3–4 Weeks | 6–10 Weeks |
Physician Insight & Safety Protocol
“Every COL4A4 result must be interpreted in the context of family history, renal function, and audiological phenotype. A negative result does not exclude other Alport-related genes, and a positive result empowers early intervention – but should never replace specialist monitoring.” — Dr. PRABHAKAR REDDY, DHA: 61713011
⚠ Clinical Medication Warning: Do not discontinue prescribed medication (e.g., ACE inhibitors, immunosuppressants) without consulting your physician. Genetic test results alone do not dictate immediate therapy changes.
Exclusion Criteria & ER Red Flags
- Active infection requiring antibiotic treatment – reschedule collection after recovery.
- Severe haemorrhagic disorder or anticoagulant overdose – coordinate with haematology prior to phlebotomy.
- Not to be collected from minors under 4 years without paediatric phlebotomy protocol and consent under CDS Law 2026.
- Emergency red flags: Sudden hearing loss with vertigo, rapid vision loss, or gross haematuria with oliguria – proceed directly to ER; do not wait for genetic results.
Patient FAQ & Clinical Guidance
Q: How accurate is this test for diagnosing Alport syndrome?
س: ما مدى دقة هذا الفحص لتشخيص متلازمة ألبورت؟
This NGS test achieves 99.9% analytical sensitivity for COL4A4 mutations when performed on blood or FTA card DNA, meaning it detects virtually all known pathogenic variants including deep intronic and copy-number changes. Clinical sensitivity reaches >95% in patients with classic renal and auditory signs, and we confirm every pathogenic call with orthogonal Sanger sequencing.
Q: Can I use a home collection for my child?
س: هل يمكنني استخدام خدمة السحب المنزلي لطفلي؟
Yes, our DHA‑licensed paediatric phlebotomists perform safe, pain-minimised home collections for children aged 4 and above, with strict adherence to UAE Child Protection Law (CDS 2026). For infants or high-risk minors, we arrange a paediatric clinical collection; a genetic counselling session with pedigree chart drawing is mandatory prior to sampling.
Q: What happens after I receive a positive result?
س: ماذا يحدث بعد الحصول على نتيجة إيجابية؟
A positive COL4A4 result triggers immediate clinical correlation with your ordering ENT or nephrology consultant, followed by a structured care pathway including audiological assessment, renal function monitoring, and ocular screening. We provide a complimentary telephonic explanation and can refer you to DHA‑accredited Alport syndrome specialists within 24 hours.
This service complies with Federal Decree‑Law No. 41 of 2024 (Art. 87), UAE Personal Data Protection Law (PDPL), and CDS Law 2026 for minors. All data is processed under DHA License 9834453 with ISO 9001:2015 certification (INT/EGQ/2509DA/3139). Results are for medical diagnostic purposes and must be interpreted by a qualified healthcare professional.
Pre‑ requirements: full clinical history, prior genetic counselling with a pedigree chart. TAT: 3–4 weeks. Contact WhatsApp: +971 54 548 8731.
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توقف عن التخمين. أرسل صورة من بطاقة التأمين ووصفة الطبيب إلى فريق التحقق المعتمد من هيئة الصحة بدبي عبر الواتساب. احصل على تحديث الحالة في دقائق.
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All reports reviewed by DHA-Certified physicians