Test Price
2,800 AED✅ Home Collection Available
CLDN19 Gene Hypomagnesemia Type 5 Genetic Test in UAE | 2800 AED
Executive Summary & Core Metrics
✓ 99.9% Diagnostic Sensitivity – ISO 9001:2015 accredited NGS processing (Cert: INT/EGQ/2509DA/3139)
✓ VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection – Available daily from 8 AM to 11 PM
✓ Telephonic Clinical Guidance – Post‑test result interpretation with DHA‑licensed genetics specialist
✓ Insurance Support – Direct billing verification via WhatsApp: +971 54 548 8731
This comprehensive genetic test uses Next‑Generation Sequencing (NGS) to accurately detect mutations in the CLDN19 gene associated with hypomagnesemia type 5. It delivers 99.9% diagnostic accuracy through a DHA‑licensed and ISO 9001:2015 certified laboratory. The service includes VIP home phlebotomy across the UAE, post‑test clinical guidance, and insurance verification via WhatsApp.
Test Overview & Methodology
The CLDN19 Gene Hypomagnesemia Type 5 Genetic Test is a definitive molecular assay that sequences the entire coding region of the CLDN19 gene to pinpoint pathogenic mutations responsible for familial primary hypomagnesemia with renal magnesium wasting. In the UAE, this test is the cornerstone for distinguishing type 5 hypomagnesemia from other metabolic disorders, enabling targeted therapy and informed genetic counseling.
| Feature | Our Test (NGS) | Closest Alternative (Sanger Sequencing) |
|---|---|---|
| Technology | Next‑Generation Sequencing (Massively Parallel) | Single‑gene Sanger Sequencing |
| Coverage | Full CLDN19 gene (all exons + splice sites) | Usually limited to known hotspot regions |
| Turnaround Time | 3 – 4 weeks | 6 – 8 weeks |
| Cost in UAE | 2800 AED | ~4000 AED |
Physician Insight & Safety Protocols
“This CLDN19 gene sequencing test provides a definitive molecular diagnosis for inherited hypomagnesemia type 5, enabling early therapeutic intervention and informed family counseling. However, results must always be interpreted alongside serum electrolyte profiles and clinical findings. Patients should never discontinue prescribed magnesium supplementation or any other medication without direct consultation with their treating physician. Establishing a genetic diagnosis early can prevent life‑threatening arrhythmias and guide personalized magnesium therapy.”
— Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA 9294403
Safety Advisory & Clinical Warnings
⚠️ Critical Safety Information
Do not alter or discontinue prescribed magnesium, diuretics, or antihypertensives without explicit instruction from your doctor.
- Exclusion Criteria: This test is not indicated for acquired hypomagnesemia (e.g., due to chronic alcoholism or malabsorption) in the absence of a strong family history.
- Emergency Symptoms (Seek immediate care): Sudden severe muscle cramps, tetany, convulsions, or palpitations suggestive of cardiac arrhythmia – these may indicate critical hypomagnesemia requiring intravenous correction.
- Test Limitation: A negative result does not exclude other genetic forms of hypomagnesemia (e.g., TRPM6, EGF mutations); further reflex testing may be warranted.
Patient Eligibility & Exclusion Guidelines
This test is appropriate for individuals with persistently low serum magnesium (<0.7 mmol/L) accompanied by symptoms such as muscle cramps, seizures, or cardiac irregularities, particularly when a sibling or parent has similar findings. It is also recommended for asymptomatic family members of diagnosed patients to determine carrier or pre‑symptomatic status. Those with hypomagnesemia due to known acquired causes without familial history should consult their physician before ordering.
Patient FAQ & Clinical Guidance
1. What is the CLDN19 gene hypomagnesemia type 5 DNA test?
This NGS‑based genetic test detects pathogenic variants in the CLDN19 gene linked to hypomagnesemia type 5 with 99.9% accuracy. It confirms the hereditary cause of low magnesium that does not respond adequately to oral supplements, guiding lifelong management and family screening.
2. Who should consider this test in the UAE?
Individuals with persistently low serum magnesium accompanied by symptoms like muscle cramps, seizures, or cardiac irregularities, especially when a close relative has been diagnosed, are ideal candidates. The test is also recommended for asymptomatic family members of a confirmed case to determine carrier or pre‑symptomatic status.
3. How does the VIP home collection service work and is it DHA‑approved?
A DHA‑licensed phlebotomist arrives at your location with a temperature‑controlled transport kit; the procedure complies fully with UAE data privacy standards. You can schedule via WhatsApp at +971 54 548 8731, and the sample is processed in our ISO 9001:2015 certified laboratory under strict chain‑of‑custody protocols.
4. What turnaround time should I expect for results?
The typical turnaround time is 3 to 4 weeks from sample receipt, as comprehensive NGS sequencing and clinical interpretation require thorough analysis and quality checks.
5. Is genetic counseling provided after the test?
Yes, post‑test telephonic clinical guidance is provided by a DHA‑licensed genetics specialist. This session helps interpret your results, discusses inheritance risks, and guides management decisions including magnesium supplementation and family testing.
UAE Regulatory & Data Privacy Adherence
- DHA/MOHAP Compliance: All genetic testing is conducted under the regulatory framework of the Dubai Health Authority and Ministry of Health, adhering to ethical genetic testing practices.
- Data Privacy: Patient data is protected under Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. All reports are encrypted end‑to‑end and stored securely.
- Patient Consent & Medical Liability: Clinical testing safety and patient consent follow the provisions of Federal Decree-Law No. 4 of 2016 on Medical Liability.
- Accreditation: ISO 9001:2015 Quality Management System (Certificate: INT/EGQ/2509DA/3139). DHA Facility License Number: 1143.
- Contact & Scheduling: WhatsApp +971 54 548 8731 for insurance verification and appointment scheduling (available 8 AM – 11 PM daily).
Clinical & Logistical Metadata
| Test Name | CLDN19 Gene Hypomagnesemia Type 5 Genetic Test |
| Price (AED) | 2800 AED |
| Turnaround Time | 3 – 4 weeks |
| Sample Type / Matrix | Peripheral whole blood (EDTA tube) – VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection available daily from 8 AM to 11 PM |
| Methodology Used | Next‑Generation Sequencing (NGS) – Full coding region analysis |
| ICD-10-CM Code | E83.42 |
| LOINC Code | 81342-1 |
| DHA Facility License & Laboratory Address | DHA Facility License Number: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE – DNA Labs UAE |
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