Test Price
2,800 AED✅ Home Collection Available
AMELX Gene Sequencing Test (Amelogenesis Imperfecta, Type 1E) in UAE | 2800 AED
Executive Summary & Core Metrics
This advanced genetic test employs Next-Generation Sequencing (NGS) targeting the AMELX gene for the definitive diagnosis of X-linked Amelogenesis Imperfecta Type 1E. Our ISO 15189 accredited genomics facility guarantees >99.9% analytical sensitivity and specificity using a validated NGS pipeline with orthogonal confirmation. Premium service includes VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection (available daily 8 AM to 11 PM), telephonic post-test genetic counselling, and direct insurance billing verification via WhatsApp.
Test Overview & Methodology
The AMELX gene sequencing test detects single nucleotide variants and small indels within the coding region and exon-intron boundaries of the AMELX gene using high-coverage Next-Generation Sequencing (NGS). This methodology provides the highest diagnostic yield for X-linked Amelogenesis Imperfecta Type 1E, with full gene coverage including CNV detection capabilities.
| Feature | Our Test (NGS Panel) | Closest Alternative (Sanger Sequencing) |
|---|---|---|
| Precision | >99.9% Analytical Sensitivity; Full gene coverage with CNV detection capability. | Limited to targeted exons; may miss deep intronic or large deletions. |
| Methodology | NGS (Next Generation Sequencing) with orthogonal confirmation. | Single-direction capillary electrophoresis. |
| Turnaround & Reporting | 3-4 Weeks with comprehensive clinical report and genetic counselling. | Variable; often requires sequential testing of multiple exons. |
Physician Insight & Safety Protocols
"As a Consultant Medical Geneticist, I emphasize that Amelogenesis Imperfecta often presents with more than dental discolouration; it can indicate an underlying ectodermal disorder with multisystem implications. A confirmed AMELX pathogenic variant necessitates coordinated care including dental rehabilitation, dermatological evaluation, and comprehensive genetic counselling for the entire family."
— Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Advisory & Safety Precautions
This genetic test is a diagnostic tool intended for use by qualified healthcare professionals. Do not discontinue prescribed medications or dental treatments without consulting your physician. All clinical decisions should be based on a comprehensive evaluation including history, examination, and radiological findings. Results are for informational purposes and require expert interpretation.
Exclusion Criteria & Emergency Red Flags
- Inability to provide a valid blood or DNA sample (e.g., severe hemolysis, insufficient quantity).
- Lack of informed consent in accordance with Federal Decree-Law No. 4 of 2016 on Medical Liability for minors or incapacitated individuals.
- ER Red Flags: Immediate dental consultation required for associated dental abscesses, unerupted teeth causing severe pain, or feeding difficulties in infants suspected of Amelogenesis Imperfecta.
Patient FAQ & Clinical Guidance
1. What is the diagnostic accuracy of the AMELX NGS test for Amelogenesis Imperfecta?
The test delivers definitive molecular confirmation with >99.9% analytical sensitivity and specificity for variants within the coding region of the AMELX gene, utilizing a validated Next-Generation Sequencing pipeline and orthogonal confirmation to completely rule out false positives.
2. When should I consider this AMELX genetic test and what does the process involve?
This genetic test is indicated when clinical signs of Amelogenesis Imperfecta are present—such as yellow-brown discoloration, enamel pitting, or fragile teeth—especially with a family history of X-linked inheritance. The process includes a mandatory pre-test genetic counselling session, a simple blood draw (or saliva for DNA extraction), and a secure online portal for results delivery within 3-4 weeks.
3. How long does it take to receive results and how are they communicated?
The comprehensive genetic report is delivered within 3 to 4 weeks exclusively through a secure, HIPAA-compliant and UAE PDPL-conformant online portal, followed by a mandatory telephonic post-genetic counselling session with our DHA-licensed clinical team for interpretation.
UAE Regulatory & Data Privacy Adherence
Your Data. Protected by Law.
All genetic data and personal health information are handled in strict compliance with:
- Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL)
- Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields
DNA Labs UAE employs encryption, access controls, and audit logs to ensure confidentiality and integrity of your clinical data. We do not share information with third parties without your explicit consent.
Clinical & Logistical Metadata
| Test Name | AMELX Gene Sequencing (Amelogenesis Imperfecta, Type 1E) |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3-4 Weeks |
| Sample Type / Matrix | Whole Blood (EDTA), Extracted DNA, or One Drop Blood on FTA Card |
| Methodology Used | Next-Generation Sequencing (NGS) with orthogonal confirmation |
| ICD-10-CM Code | K00.4 (Disturbances in tooth formation – Amelogenesis Imperfecta) |
| LOINC Code | 81353-1 (AMELX gene targeted mutation analysis) |
| DHA Facility License & Address | License No. 1143 — Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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