Test Price
2,800 AED✅ Home Collection Available
Alpha-2-Macroglobulin Deficiency Genetic Test (A2M NGS) in Dubai, UAE
Executive Summary & Core Metrics
- Diagnostic Accuracy: 99.9% analytic sensitivity via ISO-accredited next-generation sequencing (NGS) workflow.
- VIP Mobile Phlebotomy & Cold-Chain Logistics: Temperature-controlled home collection available daily from 8 AM to 11 PM, ensuring specimen integrity from draw to laboratory reception.
- Post-Test Genetic Counselling: Complimentary telephone consultation with a DHA-licensed medical geneticist to contextualise results.
- Insurance Verification: Direct coverage check via WhatsApp +971 54 548 8731 prior to sample collection.
Test Overview & Methodology
The Alpha-2-Macroglobulin Deficiency Genetic Test employs targeted next-generation sequencing (NGS) to interrogate the full coding region and splice-site junctions of the A2M gene. This analysis detects pathogenic and likely pathogenic variants responsible for impaired protease inhibition, a rare autosomal recessive disorder linked to metabolic dysregulation, pulmonary complications, and an elevated risk of certain malignancies. DNA-level resolution identifies both heterozygous carriers and homozygous affected individuals, providing definitive molecular diagnosis where biochemical assays yield only protein-level inference.
Pre-Test Requirements
A mandatory genetic counselling session is required prior to sample collection to construct a detailed three-generation pedigree. Patients should provide comprehensive personal and family history of alpha-2-macroglobulin deficiency, metabolic disorders, or pulmonary conditions. No dietary restrictions or medication adjustments are necessary; standard venipuncture protocols apply.
| Feature | Our Test (NGS) | Closest Alternative (Biochemical Assay) |
|---|---|---|
| Method | Targeted NGS (full gene coverage) | Serum protein electrophoresis / ELISA |
| Precision | DNA-level variant detection >99.9% analytic sensitivity | Only protein level; cannot detect silent carriers |
| Turnaround Time | 3–4 Weeks | 1–3 Days |
| Price (AED) | 2,800 | ~500 |
Physician Insight & Safety Protocols
"Genetic testing for A2M deficiency provides critical insight into protease regulation pathways that influence metabolic, pulmonary, and oncological health. However, identifying a pathogenic variant is only one piece of the clinical puzzle. I strongly encourage every patient to review their results with a qualified genetic counsellor or treating physician to build a comprehensive, individualised management plan."
— Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
⚠️ Important Safety Advisory
Do not alter or discontinue any prescribed medication without explicit direction from your treating physician. Genetic test results are intended to support clinical decision-making, not to replace ongoing medical supervision or urgent care when symptoms arise.
Safety Exclusion Criteria & Emergency Red Flags
- Exclusion: Active bleeding disorder, recent major trauma or major surgery within 14 days, platelet count below 50,000/µL.
- Red Flag – Seek Emergency Care (Call 998): Sudden onset of severe dyspnoea, unexplained jaundice, or rapid onset of bruising or haemorrhage.
- Red Flag – Hepatic Decompensation Signs: Ascites, confusion, or asterixis require immediate emergency evaluation.
Patient FAQ & Clinical Guidance
1. What does the A2M gene test detect?
This test identifies disease-causing mutations in the A2M gene responsible for alpha-2-macroglobulin deficiency, a rare disorder that impairs the body's ability to inhibit proteases. Detection is critical for diagnosing the condition at the DNA level, distinguishing affected individuals from silent carriers, and informing family risk assessments.
2. How should I prepare for the blood draw?
No fasting or medication changes are required. Stay well-hydrated and inform the phlebotomist of any anticoagulant therapy or bleeding tendencies. The collection is a standard peripheral venipuncture of 5–8 mL whole blood into an EDTA tube.
3. How long do results take?
The standard turnaround time is 3 to 4 weeks from sample receipt in the laboratory. This period allows for complete gene sequencing, bioinformatic analysis, variant classification, and dual-clinician verification before report release.
4. What do the results mean for my health?
A positive result indicates a pathogenic variant that may increase risk for pulmonary emphysema, metabolic abnormalities, and certain cancers. A negative result significantly reduces the likelihood of hereditary alpha-2-macroglobulin deficiency but does not eliminate all risk. All results require interpretation by a medical geneticist within your full clinical context.
UAE Regulatory & Data Privacy Adherence
- Data Protection: All genetic data is processed and stored in full compliance with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields.
- Clinical Safety: Patient consent, specimen handling, and reporting procedures adhere to Federal Decree-Law No. 4 of 2016 on Medical Liability.
- Accreditation: The laboratory operates under ISO 15189 standards and is licensed by the Dubai Health Authority (DHA) under facility license number 1143.
- Confidentiality: Genetic information is treated as highly sensitive personal data and is never shared with third parties without explicit written patient consent.
Clinical & Logistical Metadata
| Test Name | Alpha-2-Macroglobulin Deficiency Genetic Test (A2M NGS) |
| Price (AED) | 2,800 |
| Turnaround Time | 3–4 Weeks |
| Sample Type / Matrix | Peripheral Whole Blood (EDTA) – VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection available daily from 8 AM to 11 PM |
| Methodology Used | Targeted Next-Generation Sequencing (NGS) – Full gene coverage including coding exons and splice junctions |
| ICD-10-CM Code | E88.09 |
| LOINC Code | 91854-7 |
| DHA Facility License & Laboratory Address | DHA License No. 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE – DNA Labs UAE |
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