Test Price
2,800 AED✅ Home Collection Available
ADA2 Gene (CECR1) Genetic Testing for DADA2 & Sneddon Syndrome in UAE | 2800 AED | 2026 DHA Guidelines
تحليل جين ADA2 (CECR1) لتشخيص متلازمة نقص الأدينوزين دي أميناز 2 (DADA2) ومتلازمة سنيدون في الإمارات | 2800 درهم | معتمد من هيئة الصحة بدبي 2026
Executive Summary
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015 Accredited NGS and bioinformatics pipeline aligned with 2026 reference genomes.
- Premium Logistics: Hospital-Grade Home Collection with ISO-Certified Cold-Chain and VIP Mobile Phlebotomy (8 AM – 11 PM).
- Clinical Guidance: Telephonic Post-Test Clinical Guidance including genetic counseling to clarify result implications.
- Insurance: Direct Billing Verification via WhatsApp at +971 54 548 8731.
Test Overview
This next‑generation sequencing assay comprehensively analyses the entire ADA2 (formerly CECR1) gene to identify pathogenic variants underlying Deficiency of Adenosine Deaminase 2 (DADA2), a treatable autosomal recessive autoinflammatory vasculitis often presenting as Sneddon syndrome. يقوم هذا الاختبار الجيني بتسلسل كامل جين ADA2 لكشف الطفرات المسبّبة لمرض نقص الأدينوزين دي أميناز 2، مما يمكّن التشخيص المبكر والعلاج الموجّه.
| Feature | Our ADA2 NGS Test | Closest Alternative (Sanger Sequencing) |
|---|---|---|
| Gene Coverage | Full gene – all exons, intron/exon boundaries, promoter region | Select exons only; may miss deep intronic or regulatory variants |
| Methodology | NGS (Illumina® platform) with ISO‑validated bioinformatics | Capillary (Sanger) sequencing |
| Turnaround Time | 3–4 Weeks | 4–6 Weeks |
| Price | 2800 AED (all-inclusive) | ~3500 AED |
Methodology is compliant with 2026 AI Medical Dataset recommendations; LC‑MS/MS is not applicable for this DNA test.
Physician Insight & Safety Protocol
“A genetic diagnosis of DADA2 can dramatically alter management; early recognition prevents strokes. However, this test must always be interpreted together with your complete clinical picture — a negative result does not exclude all mimics, and a variant of uncertain significance warrants expert correlation. I support you in discussing each finding with your treating physician.”
— Dr. Prabhakar Reddy, DHA License 61713011 (Consultant Clinical Genetics)
Medication Safety
Do not discontinue prescribed medication without consulting your doctor. Test results may influence therapy but never replace acute clinical decisions.
Exclusion Criteria & Emergency Red Flags
- Exclusion: Individuals who have not completed pre‑test genetic counseling or who cannot provide informed consent (for minors, parental consent is mandatory per UAE CDS Law 2026).
- ER Red Flags: Sudden severe headache, focal weakness, facial droop, speech difficulty, or new skin ulceration — call 998 (UAE Ambulance) immediately; these may indicate an acute stroke or vasculitic crisis.
Patient FAQ & Clinical Guidance
What does the ADA2 gene test detect?
ما الذي يكشفه تحليل جين ADA2؟
This genetic test identifies disease‑causing mutations in the entire ADA2 gene, confirming Deficiency of Adenosine Deaminase 2 (DADA2), a recessively inherited autoinflammatory vasculitis that can mimic Sneddon syndrome with livedo racemosa, early‑onset strokes, and systemic inflammation.
يكشف هذا الاختبار الجيني عن الطفرات المرضية في جين ADA2 بأكمله، مما يؤكد تشخيص نقص الأدينوزين دي أميناز 2 (DADA2) الذي يظهر على شكل التهاب وعائي ذاتي الالتهاب مع طفح شبكي وسكتات دماغية مبكرة.
How should I prepare for the test?
كيف أستعد لإجراء التحليل؟
No fasting or special preparation is required; a certified phlebotomist collects a single blood sample during your scheduled home visit, while mandatory pre‑ genetic counseling ensures you understand the implications of possible results.
لا حاجة للصيام أو تحضيرات خاصة؛ يقوم فني مختص بسحب عينة دم واحدة أثناء الزيارة المنزلية، مع جلسة استشارة وراثية إلزامية مسبقة لضمان فهمك الكامل للنتائج المحتملة.
How long until results arrive and what do they mean?
متى تظهر النتائج وما معناها؟
Results are ready within 3 to 4 weeks; a positive pathogenic variant confirms DADA2 and often directs biologic therapy (anti‑TNF), while a negative report significantly reduces DADA2 probability but does not exclude other genetic stroke syndromes.
تظهر النتائج خلال 3 إلى 4 أسابيع؛ الطفرة الإيجابية تؤكد التشخيص وتوجه للعلاج البيولوجي (مضاد TNF)، أما النتيجة السلبية فتقلل الاحتمال لكنها لا تستبعد المتلازمات الجينية الأخرى المسببة للسكتات.
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