Test Price
2,800 AED✅ Home Collection Available
TMC1 Gene Deafness (Autosomal Dominant Type 36) Genetic Test in UAE | 2800 AED
Executive Summary & Core Metrics
Executive Summary: This advanced genetic test detects pathogenic variants in the TMC1 gene causing autosomal dominant non-syndromic hearing loss (DFNA36) using NGS technology. The analysis is performed under UAE Federal Decree-Law No. 4 of 2016 on Medical Liability, ensuring highest standards of diagnostic accuracy and patient safety. Results empower precise prognosis, personalized auditory rehabilitation planning, and informed genetic counselling for families.
Test Overview & Methodology
The TMC1 gene test identifies pathogenic variants causing autosomal dominant non-syndromic hearing loss (DFNA36) with Next Generation Sequencing technology. It empowers accurate prognosis, personalized auditory rehabilitation, and informed genetic counselling for families.
| Feature | Our Test – NGS Panel | Closest Alternative – Sanger Single Gene |
|---|---|---|
| Methodology | NGS covering all coding exons & splice sites | Sanger sequencing – limited to known hotspots |
| Analytical Sensitivity | 99.9% for single nucleotide variants & small indels | ~99% for targeted regions only |
| Turnaround Time | 3–4 weeks | 6–8 weeks (often batched) |
| Clinical Actionability | Comprehensive variant detection enables genotype–phenotype correlation | May miss novel or deep intronic variants |
| Sample Types | Whole Blood, Extracted DNA, One-drop Blood on FTA Card | Whole blood (EDTA) only |
Physician Insight & Safety Protocols
“As a Consultant Medical Geneticist, I understand the weight of hereditary hearing loss on families. The TMC1 gene test provides definitive molecular evidence, but the full clinical picture requires audiological correlation and complete family history. I strongly advise all patients to maintain their prescribed medications and follow their ENT specialist’s recommendations. Genetic results should always be interpreted through comprehensive counselling to ensure the best outcomes.”
— Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Advisory Notice: Medication Safety
Do not discontinue prescribed medication without consulting your doctor. Stopping ototoxic drugs or any therapy without medical guidance may worsen the condition or cause irreversible damage. Always discuss medication changes with your healthcare provider before taking any action based on genetic test results.
Exclusion Criteria & Emergency Red Flags
- Acute febrile illness or recent blood transfusion (within 2 weeks) – postpone collection until fully recovered.
- Pregnancy: non-urgent genetic testing should be discussed with your obstetrician and genetic counsellor before proceeding.
- ER Red Flags: Seek immediate emergency care if you experience sudden total hearing loss, severe vertigo, ear pain, or facial weakness.
Patient FAQ & Clinical Guidance
1. What is the TMC1 genetic test and what sample is needed?
A simple blood draw or one drop of blood on an FTA card is sufficient for high-coverage NGS analysis. Our professional phlebotomist collects the sample at your home under cold-chain protocol, and the DNA is extracted in our ISO-accredited laboratory. The test specifically analyzes all coding exons and splice sites of the TMC1 gene to identify pathogenic variants causing DFNA36.
2. Can this test predict inheritance risk for my children?
Identifying a dominant TMC1 variant confirms a 50% inheritance risk for each child, enabling informed reproductive planning. A genetic counsellor integrates the result with your detailed family pedigree to calculate exact recurrence probability and discuss options such as prenatal testing or preimplantation genetic diagnosis.
3. What is the cost and do you accept insurance?
The total cost is 2,800 AED with direct insurance billing verification via WhatsApp at +971545488731. We verify coverage from major UAE insurers before your appointment, and a detailed receipt is provided for reimbursement if needed. Our team handles all administrative processes to ensure a seamless experience.
UAE Regulatory & Data Privacy Adherence
This genetic test is performed in full compliance with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Patient safety, informed consent, and clinical governance follow Federal Decree-Law No. 4 of 2016 on Medical Liability. All genetic data is processed under strict confidentiality protocols with ISO 9001:2015 certified quality management (Cert: INT/EGQ/2509DA/3139).
Clinical & Logistical Metadata
| Test Name | TMC1 Gene Deafness (Autosomal Dominant Type 36) Genetic Test |
| Price (AED) | 2,800 |
| Turnaround Time | 3–4 weeks |
| Sample Type / Matrix | Whole Blood, Extracted DNA, One-drop Blood on FTA Card |
| Methodology Used | Next Generation Sequencing (NGS) covering all coding exons and splice sites |
| ICD-10-CM Code | H90.3, H91.9 |
| LOINC Code | 82467-3 |
| DHA Facility License & Laboratory Address | DHA Facility License Number: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | Corporate Lab: DNA Labs UAE |
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