Test Price
2,800 AED✅ Home Collection Available
PRDM16 Gene Cardiomyopathy, Dilated Type 1LL Genetic Test in UAE | 2,800 AED | DHA Licensed
Executive Summary & Core Metrics
- Diagnostic Accuracy: 99.9% sensitivity via ISO 9001:2015 (Certificate No. INT/EGQ/2509DA/3139) certified next-generation sequencing platform.
- Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection available daily from 8 AM to 11 PM across all Emirates.
- Clinical Guidance: Post-test telephonic genetic counselling by Consultant Medical Genetics Lina Osama Zaki Quteineh (DHA Registration ID: 9294403).
- Insurance Facilitation: Direct verification and pre-approval documentation via WhatsApp at +971 54 548 8731.
Test Overview & Methodology
This next-generation sequencing (NGS) panel analyzes the entire coding region of the PRDM16 gene to detect pathogenic variants responsible for dilated cardiomyopathy type 1LL. The test confirms diagnosis in patients presenting with clinical signs of dilated cardiomyopathy and evaluates genetic risk among asymptomatic family members. Comprehensive coverage includes all exons, splice sites, and copy number variants.
| Feature | Our Test (PRDM16 NGS) | Closest Alternative (Single-Variant PCR) |
|---|---|---|
| Precision | Comprehensive full-gene sequencing >99.9% sensitivity for all variant types | Targeted genotyping; misses novel or rare variants (~70% coverage) |
| Method | NGS with copy number variation analysis | PCR plus Sanger sequencing for specific known mutations |
| Turnaround Time | 3–4 Weeks (ISO-accredited lab) | 5–6 Weeks (if outsourced) |
Physician Insight & Safety Protocols
"A confirmed pathogenic variant in PRDM16 establishes a genetic aetiology for dilated cardiomyopathy type 1LL; however, clinical correlation with echocardiography, electrocardiogram, and a three-generation family pedigree is essential. This molecular finding must be integrated with a complete cardiological evaluation and never interpreted in isolation."
— Lina Osama Zaki Quteineh, Consultant Medical Genetics | DHA Registration ID: 9294403Medication Advisory
Do Not Alter Prescribed Therapy Based Solely on Genetic Results
Patients must not discontinue or adjust any prescribed cardiovascular medication (e.g., beta-blockers, ACE inhibitors, diuretics) following this genetic test result. Any therapeutic changes require prior consultation with the treating cardiologist. This genetic result is a diagnostic adjunct, not a standalone treatment directive.
Safety Exclusion Criteria & Emergency Red Flags
- Exclusion Criteria: Inability to provide informed consent; minors without legal guardian consent in accordance with Federal Decree-Law No. 4 of 2016 on Medical Liability; patients in acute decompensated heart failure requiring immediate medical stabilisation.
- Emergency Red Flags: Sudden onset syncope, crushing chest pain radiating to the arm or jaw, or acute shortness of breath at rest warrants immediate emergency medical attention — do not delay care awaiting genetic results.
Patient FAQ & Clinical Guidance
1. What is the PRDM16 gene and how does it cause dilated cardiomyopathy?
The PRDM16 gene encodes a transcription factor critical for myocardial development and contractile function. Pathogenic variants disrupt cardiac gene expression programs, leading to progressive ventricular dilation and systolic dysfunction characteristic of dilated cardiomyopathy type 1LL. Our NGS assay detects single nucleotide variants, insertions, deletions, and copy number changes across all coding exons and flanking intronic regions. Genetic counselling before and after testing is integral to the service.
2. How is the test performed and what are the pre-test requirements?
Sample collection requires a single peripheral blood draw (3–5 mL in EDTA) or a dried blood spot on an FTA card collected by our trained phlebotomist. No fasting is required. A mandatory pre-test genetic counselling session, including construction of a three-generation pedigree chart, ensures fully informed consent. Patients must provide a detailed clinical history and any prior cardiac imaging reports. The sample is transported via temperature-controlled cold chain to our ISO-accredited laboratory for NGS analysis.
3. Is this genetic test covered by health insurance in the UAE?
Many UAE health insurance policies now include cardiogenetic testing when deemed medically necessary by a specialist. Our team facilitates direct verification and pre-approval documentation via WhatsApp at +971 54 548 8731. Relevant ICD-10-CM codes (I42.0, Z13.6, Z15.89) and LOINC coding are provided to support reimbursement. Coverage varies by insurer; we recommend confirming benefits prior to sample collection.
UAE Regulatory & Data Privacy Adherence
Data Protection & Confidentiality: All genetic data is processed and stored in full compliance with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Patient genomic information is encrypted end-to-end, access-restricted to authorised clinical personnel, and never shared with third parties without explicit written consent. Laboratory operations adhere to DHA standards for genetic data governance and ISO 15189 quality management principles.
Clinical & Logistical Metadata
| Test Name | PRDM16 Gene Sequencing – Dilated Cardiomyopathy Type 1LL (NGS) |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3–4 Weeks |
| Sample Type / Matrix | Whole Blood (EDTA), Dried Blood Spot (FTA Card), or Extracted DNA |
| Methodology Used | Next-Generation Sequencing (NGS) with Copy Number Variation (CNV) Analysis |
| ICD-10-CM Code | I42.0, Z13.6, Z15.89 |
| LOINC Code | 103388-3 |
| DHA Facility License & Address | License No. 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | Corporate Lab: DNA Labs UAE |
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