Test Price
700 AED✅ Home Collection Available
iAMP21 (Intrachromosomal Amplification of Chromosome 21) FISH Test in UAE | 700 AED | DHA Licensed
This advanced genetic FISH assay detects iAMP21—a high-risk marker in B-cell acute lymphoblastic leukemia (B-ALL)—with 99.9% diagnostic sensitivity, enabling precise risk stratification and tailored treatment planning under DHA pediatric oncology protocols.
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015 Accredited Processing (Cert: INT/EGQ/2509DA/3139).
- Collection Protocol: Hospital Extraction Only – Sample collection is conducted strictly within an accredited hospital facility; mobile home phlebotomy is disabled for safety.
- Clinical Guidance: Telephonic Post-Test Clinical Guidance in result interpretation by a DHA-licensed specialist.
- Insurance: Direct Billing Verification via WhatsApp at +971 54 548 8731.
Test Overview & Methodology
This test employs Fluorescence In-Situ Hybridization (FISH) with dual-color RUNX1-specific DNA probes to detect intrachromosomal amplification of chromosome 21 (iAMP21) in bone marrow aspirate samples. The procedure follows ISO 15189‑compliant protocols with automated signal enumeration, delivering single-cell resolution for low-level clone detection. iAMP21 is a well-established high-risk cytogenetic marker in pediatric B-ALL, associated with a lower event-free survival if managed with standard therapy alone. Early and accurate identification enables oncologists to escalate treatment intensity according to DHA‑approved risk‑adapted protocols.
| Feature | Our iAMP21 FISH Test | Conventional Cytogenetics |
|---|---|---|
| Precision | Targeted RUNX1 probes for iAMP21 clone detection at single-cell level | Whole-genome analysis with limited resolution, may miss low-level clones |
| Methodology | ISO 15189‑compliant FISH with automated signal counting | G‑banded karyotyping, requiring viable dividing cells |
| Turnaround Time | 3–4 working days | 10–14 working days |
Physician Insight & Safety Protocols
“iAMP21 is a critical genetic determinant in pediatric B-ALL that directly impacts risk stratification and treatment intensity. A positive finding should be correlated with complete blood counts, bone marrow morphology, and flow cytometry to assign the correct therapeutic arm. I strongly recommend that all patients with iAMP21 undergo evaluation by a pediatric hematologist-oncologist to optimize chemotherapy protocols in line with DHA guidelines.”
— Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Medication Advisory & Clinical Precautions
Exclusion Criteria & Emergency Red Flags
- This test is not applicable for pre-surgical clearance, pregnancy assessment, or travel fitness certification.
- ER Red Flag: If severe bleeding, fever >38°C, or sudden clinical deterioration occurs, proceed to the nearest DHA-licensed emergency department immediately—do not wait for test results.
Patient FAQ & Clinical Guidance
1. What is the clinical significance of iAMP21 in leukemia?
iAMP21 is a high-risk genetic abnormality in B-ALL that demands intensified chemotherapy and close monitoring. This alteration involves amplification of the RUNX1 gene on chromosome 21 and is associated with a poorer prognosis when not treated aggressively. Early detection allows oncologists to assign patients to the appropriate risk‑adapted treatment arm as per DHA pediatric oncology protocols.
2. How is the bone marrow collection performed and is it painful?
Bone marrow aspiration is performed under local anesthesia by a qualified DHA‑licensed specialist in an accredited hospital setting. For pediatric patients, age‑appropriate sedation is administered by a consultant pediatric anesthetist to ensure a pain‑free, stress‑free experience. The sample is transported via secure medical courier in an ISO‑certified cold‑chain container directly to our laboratory.
3. What happens if the test detects iAMP21 but I have no symptoms?
A positive result in asymptomatic individuals warrants urgent hematologist-oncologist evaluation to rule out occult leukemia or clonal evolution. Even in the absence of overt clinical signs, iAMP21 may indicate a premalignant state or minimal residual disease requiring further investigation, such as flow cytometry and morphological review. Do not ignore the result; follow the consultative guidance provided by our post‑support team.
UAE Regulatory & Data Privacy Adherence
Data Protection & Health Information Governance
DNA Labs UAE operates under DHA Facility License No. 1143 and complies fully with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. All genetic data is encrypted, access‑controlled, and processed exclusively within UAE jurisdiction.
Clinical Safety & Patient Consent: All procedures adhere to Federal Decree-Law No. 4 of 2016 on Medical Liability, ensuring written informed consent is obtained prior to bone marrow aspiration and that patients are fully informed of the risks, benefits, and implications of genetic testing.
Clinical & Logistical Metadata
| Test Name | iAMP21 (Intrachromosomal Amplification of Chromosome 21) FISH Test |
| Price (AED) | 700 AED |
| Turnaround Time | 3–4 working days |
| Sample Type / Matrix | Bone Marrow Aspirate (Hospital Extraction Only) |
| Methodology Used | Fluorescence In-Situ Hybridization (FISH) with dual-color RUNX1 probes, ISO 15189‑compliant |
| ICD-10-CM Code | C91.00 (Acute lymphoblastic leukemia [ALL] not having achieved remission) |
| LOINC Code | 94373-8 (iAMP21 FISH) |
| DHA Facility License & Laboratory Address | License No. 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE – DNA Labs UAE |
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