NPM1 Gene Mutation Test in UAE | 800 AED | DHA Licensed Laboratory

Executive Summary & Core Metrics

Core Metrics

Price: 800 AED
Turnaround Time: 2–3 Working Days
Sample Type: Peripheral Blood (Bone Marrow Aspirate also available by clinical necessity)
Methodology: Real-Time PCR with Confirmatory Sequencing
Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO Accredited Processing
Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection for blood samples; bone marrow aspiration conducted at hospital only
Clinical Guidance: Telephonic Post-Test Clinical Guidance in result interpretation
Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731

Test Overview & Methodology

The NPM1 Gene Mutation Test identifies mutations in the nucleophosmin 1 (NPM1) gene, a key diagnostic and prognostic marker for acute myeloid leukemia (AML). This gold-standard molecular assay uses real-time PCR for mutation detection followed by confirmatory sequencing, providing high sensitivity and specificity. The test results are essential for risk stratification and guiding targeted therapy, especially for AML patients with normal karyotype.

Feature	Our Test (NPM1 PCR + Sequencing)	Conventional Karyotyping
Precision	99.9% sensitivity for common mutations; detects rare variants via sequencing	~80% sensitivity; limited to visible chromosomal changes
Method	Real-Time PCR + Confirmatory Sequencing	G-banding cytogenetics; culture required
Speed	2–3 working days	7–14 days

Physician Insight & Safety Protocols

“The NPM1 mutation is a critical prognostic marker in AML. Its accurate detection allows for risk-adapted therapy and targeted treatment decisions. Our integrated molecular platform ensures that results are delivered with the precision and speed necessary to guide clinical management effectively. Always interpret results in the context of complete blood counts, blast percentage, and other genetic markers.”

— Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403

Advisory: Medication Warning

Warning: Do not discontinue prescribed medication without consulting your doctor.

Exclusion Criteria & Emergency Red Flags

Unable to provide informed consent or complete Genomics Clinical Information Form 20.
Patients on anticoagulant therapy where bone marrow biopsy is contraindicated; alternative blood sampling may be considered.
Minors must have guardian consent in compliance with Federal Decree-Law No. 4 of 2016 on Medical Liability and Federal Law No. 2 of 2019 concerning health information.
Emergency Red Flags: If you experience severe bone pain, fever above 38.5°C, or uncontrolled bleeding after sample collection, seek emergency medical care immediately.

Patient FAQ & Clinical Guidance

1. What is the NPM1 Gene Mutation Test?

The NPM1 gene mutation test identifies genetic abnormalities in the nucleophosmin 1 gene, commonly found in acute myeloid leukemia (AML). It helps predict prognosis and guides targeted therapy. Our laboratory uses dual-method validation to eliminate false positives.

2. Why is this test important for AML?

This test determines your AML subtype and risk category, essential for selecting appropriate therapy. NPM1-mutated AML typically has a favourable outcome, and detecting the mutation early influences decisions on chemotherapy intensity or stem cell transplant.

3. How is the sample collected?

A trained phlebotomist will collect a peripheral blood sample from your arm. If medically indicated, a bone marrow aspirate may be performed under local anaesthesia at a hospital. For blood samples, VIP mobile phlebotomy is available at your home (daily 8 AM – 11 PM).

4. What is the turnaround time for results?

Results are typically available within 2–3 working days after sample receipt. A detailed clinical report will be shared with you and your referring physician, along with telephonic guidance if needed.

UAE Regulatory & Data Privacy Adherence

Your data is handled in strict compliance with:

Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) – ensuring the confidentiality and security of your personal information.
Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields – regulating digital health records and telemedicine.
Federal Decree-Law No. 4 of 2016 on Medical Liability – governing patient consent and clinical safety.

All laboratory procedures are ISO accredited and audited regularly by the Dubai Health Authority.

Clinical & Logistical Metadata

Test Name	NPM1 Gene Mutation Test
Price (AED)	800
Turnaround Time	2–3 Working Days
Sample Type / Matrix	Peripheral Blood or Bone Marrow Aspirate
Methodology Used	Real-Time PCR with Confirmatory Sequencing
ICD-10-CM Code	C92.00
LOINC Code	81657-0
DHA Facility License & Laboratory Address	DHA Facility License Number: 1143 Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE Corporate Lab Branding: DNA Labs UAE

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