Test Price
650 AED✅ Home Collection Available
t(4;11)(q21;q23) [MLL-AF4] Fusion Transcript PCR Qualitative Test in UAE | 650 AED | 2026 DHA Guidelines
تحليل اندماج الجين MLL-AF4 (t(4;11)) النوعي بتفاعل البوليميراز المتسلسل في الإمارات | 650 درهم | معتمد من هيئة الصحة بدبي
ملخص تنفيذي: يوفر هذا التحليل الجزيئي المتطور كشفًا نوعيًا لاندماج الجين MLL-AF4 المرتبط بابيضاض الدم الليمفاوي الحاد، بدقة تشخيصية تبلغ 99.9% عبر معالجة مخبرية حاصلة على شهادة ISO. تشمل الخدمة سحب عينات منزلية فاخرة على مستوى المستشفيات عبر سلسلة تبريد معتمدة، مع استشارة هاتفية بعد النتائج لتفسيرها سريريًا. التحقق من التغطية التأمينية متاح عبر واتساب على الرقم +971545488731.
Test Overview: Gold-Standard Molecular Detection for MLL-Rearranged Leukemia
This qualitative real-time PCR test definitively detects the t(4;11)(q21;q23) translocation producing the MLL-AF4 fusion transcript, a hallmark of high-risk acute lymphoblastic leukemia (ALL) predominantly in infants. هذا الفحص الجزيئي يكشف بدقة عن اندماج MLL-AF4، وهو علامة حيوية لابيضاض الدم الليمفاوي الحاد عالي الخطورة، خاصةً لدى الرضع.
| Parameter | Our Test (Precision Diagnostics) | Alternatives (Conventional Cytogenetics) |
|---|---|---|
| Methodology | Real-Time PCR (qPCR) with melt curve analysis | Karyotyping / FISH |
| Sensitivity | Detects 1 leukemic cell in 10,000 (10-4) | ~5-10% abnormal metaphases required |
| Turnaround Time | Sample Mon/Thu by 11 AM; Report Wed/Sat | 10–14 days |
| Specimen | Bone marrow or 3 mL whole blood (Lavender EDTA) | Bone marrow aspirate |
*Price: 650 AED. Home collection available 8 AM – 11 PM.
Physician Insight & Clinical Correlation Protocol
"As a DHA-licensed hematopathologist, I emphasize that the MLL-AF4 fusion transcript is a critical driver of aggressive infant and adult ALL. While a positive qualitative PCR result carries profound prognostic weight, it must always be interpreted alongside morphology, flow cytometry, and clinical presentation. Never treat numbers alone – treat the patient."
— Dr. PRABHAKAR REDDY, DHA License 61713011
Medication Warning:
Do not discontinue any prescribed medication, including corticosteroids or tyrosine kinase inhibitors, without explicit guidance from your treating oncologist. Abrupt cessation may precipitate blast crisis.
⚠ Pre-Analytical Safety & Exclusion Criteria
- Specimen Rejection: Frozen samples, clotted bone marrow, tubes without EDTA, or volume <2 mL will be rejected. Transport refrigerated (2–8°C). DO NOT FREEZE.
- Mandatory Paperwork: Complete clinical history including CBC, blast percentage, and prior cytogenetics must accompany the requisition. Missing history will delay processing.
- Patient Red Flags: If the patient has active severe sepsis, hemodynamic instability, or suspected tumor lysis syndrome, sample collection should be deferred until clinically stable.
- Emergency Signs: Seek immediate hospital care if the patient develops fever >38.5°C, uncontrolled bleeding, seizure, or altered consciousness while awaiting results. These may indicate leukostasis or infection.
- Paediatric Protocol: For minors (<18 years), written parental consent is mandatory per UAE CDS Law 2026. DHA-licensed phlebotomists follow pediatric pain management guidelines.
Frequently Asked Questions & Clinical Guidance
1. How sensitive is this for detecting minimal residual disease (MRD) in MLL-AF4 ALL?
This qualitative PCR detects the fusion transcript with a sensitivity of at least 1 in 10,000 cells (10-4), but for MRD monitoring, a quantitative assay (RQ-PCR) is recommended to track log reduction. A positive result confirms the transcript’s presence and guides early therapeutic stratification, while a negative result should be correlated with morphological remission before concluding MRD negativity.
2. What does a positive MLL-AF4 result mean for my child’s treatment plan?
In infants and young children, MLL-AF4 rearrangement confers an adverse prognosis and typically necessitates an intensive chemotherapy backbone with consideration for allogeneic stem cell transplantation in first complete remission. The result directly influences hematopoietic stem cell donor search and eligibility for clinical trials targeting menin-MLL interactions.
3. هل يمكن إجراء هذا التحليل من عينة الدم المحيطي فقط دون بزل النخاع؟
نعم، يمكن الكشف عن اندماج MLL-AF4 من عينة الدم المحيطي إذا كانت نسبة الخلايا الأرومية كافية، مما يجنب الطفل إجراء البزل المتكرر، ولكن الحساسية تظل أقل مقارنة بعينة النخاع. لذا يُفضل النخاع لتأكيد التشخيص الأولي.
(Yes, peripheral blood can be used if the blast percentage is adequate to avoid repeated bone marrow aspiration in children, though marrow remains the gold standard for initial diagnosis due to higher sensitivity.)
UAE Regulatory Compliance: This laboratory strictly adheres to Federal Decree-Law No. 41 of 2024 on Medical Liability, UAE Personal Data Protection Law (PDPL), and CDS Law 2026 provisions for minors. Patient data is encrypted and processed under ISO 9001:2015 (Cert: INT/EGQ/2509DA/3139). Telephonic clinical guidance is provided for informational purposes and does not replace a face-to-face consultation. For insurance pre-authorization, send your Emirates ID and policy card via WhatsApp at +971 54 548 8731.
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