RET Gene (10q11.2) Rearrangement FISH Test in UAE | 1700 AED | DHA Licensed

Executive Summary & Core Metrics

Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015 Accredited Processing.

Premium Logistics: Secure Medical Courier Solid Tissue Specimen Retrieval for archival FFPE blocks and biopsy slides.

Clinical Guidance: Telephonic Post-Test Clinical Guidance in result interpretation by a Consultant Medical Genetics.

Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.

Test Overview & Methodology

The RET Gene (10q11.2) Rearrangement FISH Test identifies oncogenic rearrangements of the RET proto-oncogene using dual-color break-apart fluorescence probes. This molecular cytogenetic assay is pivotal for confirming medullary thyroid carcinoma (MTC), papillary thyroid carcinoma (PTC), and selecting RET-targeted therapies including selpercatinib and pralsetinib.

Feature	Our RET FISH Test	Closest Alternative
Methodology	FISH with dual-color break-apart probes, ISO 9001:2015 validated	Standard FISH or PCR-based methods, may lack ISO accreditation
Diagnostic Specificity	99.9% for RET rearrangements when tumor tissue ≥10%	Variable; typically 95–98%
Turnaround Time	4 Working Days	7–14 days

Physician Insight & Safety Protocols

“As a DHA-licensed Consultant Medical Genetics, I emphasize that RET rearrangement results must always be interpreted alongside full histopathology and clinical findings. A positive result guides targeted therapy with RET inhibitors such as selpercatinib, while a negative result does not completely rule out malignancy. Correlation with immunohistochemistry and comprehensive mutational analysis is recommended for definitive clinical decision-making.”

— Lina Osama Zaki Quteineh, Consultant Medical Genetics | DHA Registration ID: 9294403

Medication Safety Advisory

Do Not Alter Prescribed Therapy Without Specialist Consultation

This test is for diagnostic evaluation only. Continue all prescribed medications unless explicitly directed otherwise by your treating physician. Results must be reviewed with your specialist before any therapeutic adjustments are made.

Exclusion Criteria & Emergency Red Flags

Specimens with <10% tumor content are unsuitable; rebiopsy may be required.
If you experience rapid neck swelling, difficulty breathing, or severe pain, proceed to the nearest hospital immediately — testing is not an emergency procedure.
Minors: Written guardian consent is mandatory per UAE Federal Law No. 2 of 2019. Guardian presence is required during any specimen collection procedure.
Pregnant individuals: FISH testing is performed on archival tissue, but inform your physician if pregnancy is suspected due to implications of subsequent therapies.

Patient FAQ & Clinical Guidance

1. What is the turnaround time for the RET FISH test?

Your report is delivered within 4 working days from receipt of a suitable FFPE tissue block or biopsy slide containing adequate tumor content.

2. How is the specimen collected for this test?

This test requires an archival FFPE tissue block or biopsy slides from a previous surgical procedure. Our secure medical courier service coordinates specimen retrieval from your hospital or clinic. Home phlebotomy is not applicable for this tissue-based assay.

3. Does UAE health insurance cover this test?

Most UAE insurers cover RET FISH testing when deemed medically necessary by your referring physician. Direct billing verification is available via WhatsApp at +971 54 548 8731.

4. Who should consider this test?

This test is indicated for patients with confirmed or suspected medullary thyroid carcinoma (MTC) or papillary thyroid carcinoma (PTC), particularly when RET-targeted therapy is being considered. It is also used for risk stratification in hereditary thyroid cancer syndromes.

UAE Regulatory & Data Privacy Adherence

All genetic and genomic data processed through this assay is handled in strict compliance with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Clinical testing safety and patient consent protocols adhere to Federal Decree-Law No. 4 of 2016 on Medical Liability. DNA Labs UAE operates under DHA Facility License Number 1143 and maintains ISO 9001:2015 certification for quality management systems.

Clinical & Logistical Metadata

Test Name	RET Gene (10q11.2) Rearrangement FISH Test
Price (AED)	1,700
Turnaround Time	4 Working Days
Sample Type / Matrix	Formalin-Fixed Paraffin-Embedded (FFPE) Tissue Block or Biopsy Slides
Methodology Used	Dual-Color Break-Apart Fluorescence In Situ Hybridization (FISH)
ICD-10-CM Code	C73 (Malignant neoplasm of thyroid gland)
LOINC Code	60521-6 (RET gene rearrangement [Presence] in Tissue by FISH)
DHA Facility License & Address	License No. 1143 \| Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE