Also known as: Edwards Syndrome Test, Trisomy 18 FISH
Test Price
750 AEDโ Home Collection Available
๐ Results in 5โ7 working days
FISH Trisomy 18 (Edwards Syndrome) Test in UAE โ 750 AED โ DHA Licensed
Executive Summary & Core Metrics
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015 Accredited Processing.
- Sample Collection: Hospital Extraction Only โ Sample collection is conducted strictly within an accredited hospital facility; mobile home phlebotomy is disabled for safety.
- Clinical Guidance: Telephonic Post-Test Clinical Guidance in result interpretation by a DHA-licensed specialist.
- Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.
Test Overview & Methodology
The FISH Trisomy 18 test rapidly detects whole or partial triplication of chromosome 18 โ the molecular hallmark of Edwards syndrome โ using fluorescence probes, providing a definitive result in just one week from amniotic fluid, blood, or bone marrow. The test employs interphase fluorescence in situ hybridization (FISH) with locus-specific probes targeting chromosome 18, eliminating the need for cell culture and enabling analysis even from non-dividing cells.
| Feature | FISH Trisomy 18 (DHA-Approved) | Standard Karyotyping |
|---|---|---|
| Precision | >99.9% sensitivity for common aneuploidies; directly targets chromosome 18 with locus-specific probes | ~99% sensitivity but requires cultured cells; risk of culture failure |
| Method | Interphase FISH โ no cell culture needed, works on nonโdividing cells | Gโbanded karyotype โ requires 7โ10 days of cell culture |
| Speed | Results in 1 week (5โ7 working days) | Results in 2โ3 weeks |
Physician Insight & Safety Protocols
โAs a Consultant Medical Genetics overseeing this test, I emphasize that a positive FISH result for trisomy 18 must always be correlated with ultrasound findings and clinical examination. This test offers unparalleled speed, but definitive diagnosis in mosaic or translocation cases may require confirmatory karyotype. We prioritize patient counseling before and after the test to ensure understanding and emotional support.โ
โ Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration: 9294403
Advisory โ Medication & Clinical Management
โ ๏ธ Medication Warning
Do not discontinue prescribed medication without consulting your doctor. This test does not assess drug levels and is not a substitute for medical management.
Exclusion Criteria & Emergency Red Flags
- Exclusion: Known bleeding disorder or current anticoagulant therapy that cannot be safely paused (for invasive sample collection).
- Exclusion: Inability to provide valid informed consent (including Form 18 for prenatal testing).
- Emergency Red Flag: Heavy, uncontrolled bleeding or sudden severe pain at the sample collection site โ proceed to nearest ER.
- Emergency: Signs of infection (fever >38ยฐC, purulent discharge) after amniocentesis or marrow draw.
Patient FAQ & Clinical Guidance
1. What is the clinical value of this FISH Trisomy 18 test during pregnancy?
This test provides a rapid, highly accurate prenatal diagnosis of Edwards syndrome using a single draw of amniotic fluid, guiding critical pregnancy decisions with 99.9% confidence.
2. How should I prepare before the test, and are there any special documents required?
You must submit a fully completed Chromosome & FISH Analysis Requisition Form (Form 17) and a signed Prenatal Genetic Testing Consent Form (Form 18) prior to sample collection.
3. Can this FISH differentiate between full trisomy and mosaic Edwards syndrome?
Interphase FISH can detect trisomy 18 in a high percentage of cells, strongly suggesting mosaicism, but definitive mosaic quantification may require a complementary karyotype analysis.
UAE Regulatory & Data Privacy Adherence
This test is fully compliant with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. All patient data is encrypted, processed in UAE-secure servers, and never shared without explicit consent in accordance with DHA regulations.
Clinical & Logistical Metadata
| Test Name | FISH Trisomy 18 (Edwards Syndrome) โ Fluorescence In Situ Hybridization |
| Price (AED) | 750 |
| Turnaround Time | 5โ7 working days (1 week) |
| Sample Type / Matrix | Amniotic fluid, peripheral blood, or bone marrow aspirate |
| Methodology Used | Interphase Fluorescence In Situ Hybridization (FISH) with chromosome 18 locus-specific probes |
| ICD-10-CM Code | Q91.0 (Trisomy 18, non-mosaic), Q91.1 (mosaic), Q91.2 (translocation) |
| LOINC Code | 82121-4 (FISH Chromosome 18 analysis) |
| DHA Facility License & Laboratory Address | DHA License No: 1143 โ Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE โ DNA Labs UAE |
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Available in Arabic, English, Hindi & Urdu
Preparation Required
["Submit completed Chromosome & FISH Analysis Requisition Form (Form 17)", "Submit signed Prenatal Genetic Testing Consent Form (Form 18)"]
Medically Reviewed by Dr. Lina Osama Zaki Quteineh
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