FISH Trisomy 18 (Edwards Syndrome) Test in UAE – 750 AED – DHA Licensed

Item: FISH Trisomy 18 (Edwards Syndrome) Test
Author: Dr. PRABHAKAR REDDY

Executive Summary & Core Metrics

Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015 Accredited Processing.
Sample Collection: Hospital Extraction Only – Sample collection is conducted strictly within an accredited hospital facility; mobile home phlebotomy is disabled for safety.
Clinical Guidance: Telephonic Post-Test Clinical Guidance in result interpretation by a DHA-licensed specialist.
Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.

Test Overview & Methodology

The FISH Trisomy 18 test rapidly detects whole or partial triplication of chromosome 18 – the molecular hallmark of Edwards syndrome – using fluorescence probes, providing a definitive result in just one week from amniotic fluid, blood, or bone marrow. The test employs interphase fluorescence in situ hybridization (FISH) with locus-specific probes targeting chromosome 18, eliminating the need for cell culture and enabling analysis even from non-dividing cells.

Feature	FISH Trisomy 18 (DHA-Approved)	Standard Karyotyping
Precision	>99.9% sensitivity for common aneuploidies; directly targets chromosome 18 with locus-specific probes	~99% sensitivity but requires cultured cells; risk of culture failure
Method	Interphase FISH – no cell culture needed, works on non‑dividing cells	G‑banded karyotype – requires 7‑10 days of cell culture
Speed	Results in 1 week (5‑7 working days)	Results in 2‑3 weeks

Physician Insight & Safety Protocols

“As a Consultant Medical Genetics overseeing this test, I emphasize that a positive FISH result for trisomy 18 must always be correlated with ultrasound findings and clinical examination. This test offers unparalleled speed, but definitive diagnosis in mosaic or translocation cases may require confirmatory karyotype. We prioritize patient counseling before and after the test to ensure understanding and emotional support.”

— Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration: 9294403

Advisory – Medication & Clinical Management

⚠️ Medication Warning

Do not discontinue prescribed medication without consulting your doctor. This test does not assess drug levels and is not a substitute for medical management.

Exclusion Criteria & Emergency Red Flags

Exclusion: Known bleeding disorder or current anticoagulant therapy that cannot be safely paused (for invasive sample collection).
Exclusion: Inability to provide valid informed consent (including Form 18 for prenatal testing).
Emergency Red Flag: Heavy, uncontrolled bleeding or sudden severe pain at the sample collection site → proceed to nearest ER.
Emergency: Signs of infection (fever >38°C, purulent discharge) after amniocentesis or marrow draw.

Patient FAQ & Clinical Guidance

1. What is the clinical value of this FISH Trisomy 18 test during pregnancy?

This test provides a rapid, highly accurate prenatal diagnosis of Edwards syndrome using a single draw of amniotic fluid, guiding critical pregnancy decisions with 99.9% confidence.

2. How should I prepare before the test, and are there any special documents required?

You must submit a fully completed Chromosome & FISH Analysis Requisition Form (Form 17) and a signed Prenatal Genetic Testing Consent Form (Form 18) prior to sample collection.

3. Can this FISH differentiate between full trisomy and mosaic Edwards syndrome?

Interphase FISH can detect trisomy 18 in a high percentage of cells, strongly suggesting mosaicism, but definitive mosaic quantification may require a complementary karyotype analysis.

UAE Regulatory & Data Privacy Adherence

This test is fully compliant with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. All patient data is encrypted, processed in UAE-secure servers, and never shared without explicit consent in accordance with DHA regulations.

Clinical & Logistical Metadata

Test Name	FISH Trisomy 18 (Edwards Syndrome) – Fluorescence In Situ Hybridization
Price (AED)	750
Turnaround Time	5–7 working days (1 week)
Sample Type / Matrix	Amniotic fluid, peripheral blood, or bone marrow aspirate
Methodology Used	Interphase Fluorescence In Situ Hybridization (FISH) with chromosome 18 locus-specific probes
ICD-10-CM Code	Q91.0 (Trisomy 18, non-mosaic), Q91.1 (mosaic), Q91.2 (translocation)
LOINC Code	82121-4 (FISH Chromosome 18 analysis)
DHA Facility License & Laboratory Address	DHA License No: 1143 – Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE – DNA Labs UAE