Test Price
1,200 AED✅ Home Collection Available
Synovial Sarcoma SS18 FISH (Fluorescence In-Situ Hybridization) – 1200 AED
Executive Summary & Core Metrics
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO Accredited Processing.
- Premium Logistics: Secure Medical Courier Solid Tissue Specimen Retrieval – sample collection strictly from hospital archive or surgical pathology; mobile home phlebotomy is disabled for safety.
- Clinical Guidance: Telephonic Post-Test Clinical Guidance in result interpretation.
- Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.
Test Overview & Methodology
The SS18 rearrangement by FISH is the gold-standard molecular test for confirming synovial sarcoma, detecting the t(X;18)(p11.2;q11.2) translocation with near-perfect specificity. This assay directly visualizes the fusion event using break-apart or dual-fusion probes on formalin-fixed paraffin-embedded (FFPE) tumor tissue sections, providing definitive diagnostic evidence when immunohistochemistry (e.g., TLE1) yields equivocal results.
| Parameter | Our Test (FISH) | Closest Alternative (IHC/PCR) | Advantage |
|---|---|---|---|
| Method | Fluorescence In‑Situ Hybridization | Immunohistochemistry (TLE1) / RT‑PCR | Direct visualization of translocation; gold standard for definitive diagnosis |
| Sensitivity | 97–99% | 85–95% (IHC) | Fewer false negatives |
| Specificity | Near 100% | 90–96% | Minimal cross‑reactivity |
| Turnaround | 7–8 days | 3–7 days | Higher certainty within clinically acceptable time |
Physician Insight & Safety Protocols
“As a specialist in diagnostic radiology, I recognize the critical role precise molecular confirmation plays in sarcoma classification. This FISH assay provides unequivocal evidence of the SS18 rearrangement, enabling confident surgical and oncologic planning. Always correlate results with histopathology and clinical presentation before initiating therapy.”
— Mr. Prabhakar Reddy Kalathoor, Specialist Diagnostic Radiology, DHA Registration ID: 61713011
Medication & Clinical Advisory
⚠️ Important Notice
This diagnostic test is designed for evaluation purposes only. Do not alter or discontinue any prescribed treatments based solely on test results without consulting your treating physician. Clinical judgment remains paramount in all therapeutic decisions.
Exclusion Criteria & Emergency Red Flags
Exclusion Criteria
- Not indicated for asymptomatic screening; requires confirmed or suspected synovial sarcoma based on imaging or biopsy.
- Sample must be formalin‑fixed paraffin‑embedded (FFPE) tissue block or fresh tumor tissue from surgical resection or core biopsy.
- Pregnancy or lactation – test only if clinically essential and after informed consent.
Emergency Red Flags
- If you experience severe pain, uncontrolled bleeding, or signs of infection at the biopsy site, seek immediate medical attention.
- Any new or rapidly growing mass, night sweats, or unexplained weight loss warrants urgent oncology evaluation regardless of test result.
Patient FAQ & Clinical Guidance
1. What is the SS18 FISH test and why is it required?
The SS18 FISH test uses fluorescence-labeled probes to detect the characteristic t(X;18)(p11.2;q11.2) chromosomal translocation present in more than 90% of synovial sarcomas. It is required when initial histopathology or immunohistochemistry is inconclusive, or when a definitive molecular diagnosis is needed to guide surgical margins, chemotherapy regimens, or clinical trial eligibility.
2. Do I need a doctor’s prescription for this test?
Yes, a physician’s referral is mandatory for all molecular pathology tests, including SS18 FISH. The test is performed on archived tissue blocks or biopsy material, which must be requested by a licensed oncologist, surgeon, or pathologist.
3. How long do results take and how will I receive them?
Results are finalised within seven to eight working days from receipt of the tissue specimen. Reports are delivered electronically via a secure, DHA-compliant patient portal and can also be shared directly with your referring physician.
4. What sample is required and how is it collected?
The test requires a formalin-fixed paraffin-embedded (FFPE) tissue block or a fresh tumor specimen obtained during biopsy or surgery. Collection is performed exclusively within a hospital or surgical pathology laboratory; home phlebotomy is not available for this test due to the invasive nature of tissue procurement.
UAE Regulatory & Data Privacy Adherence
Regulatory Compliance Framework
- Data Protection: All patient data is processed in full compliance with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields.
- Medical Liability: Clinical testing safety and patient consent adhere to Federal Decree-Law No. 4 of 2016 on Medical Liability.
- Accreditation: DNA Labs UAE holds ISO 9001:2015 certification (INT/EGQ/2509DA/3139) and operates under DHA Facility License Number 1143.
Clinical & Logistical Metadata
| Test Name | Synovial Sarcoma SS18 FISH (Fluorescence In-Situ Hybridization) |
| Price (AED) | 1,200 AED |
| Turnaround Time | 7–8 working days |
| Sample Type / Matrix | Formalin-Fixed Paraffin-Embedded (FFPE) Tissue Block or Fresh Tumor Tissue |
| Methodology Used | Fluorescence In-Situ Hybridization (FISH) – Break-Apart Probe |
| ICD-10-CM Code | C49.9 (Malignant neoplasm of connective and soft tissue, unspecified), Z15.09 (Genetic susceptibility to other malignant neoplasm), Z80.8 (Family history of malignant neoplasm of other organs or systems) |
| LOINC Code | 77637-2 (SS18 gene rearrangement [Presence] in Tissue by FISH) |
| DHA Facility License & Laboratory Address | DHA License No: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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