Test Price
900 AED✅ Home Collection Available
FISH for Prenatal and Postnatal Diagnosis of Chromosomes 18, X, and Y
Executive Summary & Core Metrics
Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015 Accredited Processing.
Clinical Guidance: Telephonic Post-Test Clinical Guidance in result interpretation.
Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.
Specimen Collection: Hospital Extraction Only – Sample collection is conducted strictly within an accredited hospital facility; mobile home phlebotomy is disabled for safety.
Turnaround Time: 10–12 Days from sample receipt to final report.
Test Overview & Methodology
The FISH (Fluorescence In-Situ Hybridization) test rapidly detects chromosomal abnormalities in chromosomes 18, X, and Y from prenatal amniotic fluid, chorionic villus, or postnatal peripheral blood samples. This molecular cytogenetic technique provides critical results within 10–12 days for timely clinical decision-making, offering a targeted aneuploidy screening approach with sensitivity exceeding 99%.
| Parameter | FISH Test | Conventional Karyotyping |
|---|---|---|
| Precision | Targeted aneuploidy detection for chr 18, X, Y with greater than 99% sensitivity | Genome-wide, but slower and less sensitive for mosaicisms |
| Method | Fluorescence In-Situ Hybridization (rapid molecular cytogenetics) | Tissue culture and Giemsa banding |
| Speed | 10–12 Days | 14–21 Days |
Physician Insight & Safety Protocols
"As a DHA-licensed Consultant Medical Genetics specialist, I emphasize that FISH results deliver highly reliable aneuploidy detection for chromosomes 18, X, and Y, yet must always be integrated with the full clinical picture including ultrasound findings and maternal age. A negative FISH result does not exclude all chromosomal anomalies, and any positive finding should be confirmed through full karyotyping or chromosomal microarray. Patients are strongly advised to consult their referring physician before making any pregnancy management decisions."
— Lina Osama Zaki Quteineh | Consultant Medical Genetics | DHA Registration ID: 9294403
Important Safety Advisory
Do not discontinue prescribed medication or alter your treatment plan without consulting your doctor. FISH results are for diagnostic guidance and must be interpreted by a qualified healthcare professional.
Exclusion Criteria & Emergency Red Flags
- Invasive procedures (amniocentesis, CVS) carry a risk of miscarriage estimated at 1 in 300–500; written informed consent is mandatory.
- Amniocentesis must always be performed under continuous ultrasound guidance. In case of post-procedural vaginal bleeding or amniotic fluid leakage, seek emergency obstetric care immediately.
- FISH results should not be used as the sole basis for pregnancy termination without confirmatory testing via karyotyping or microarray.
Patient FAQ & Clinical Guidance
1. What is the FISH test for chromosomes 18, X, and Y?
The FISH test is a rapid molecular cytogenetic screen that detects aneuploidies such as Trisomy 18, Turner syndrome (45,X), and Klinefelter syndrome (47,XXY) directly from prenatal or postnatal specimens. Results are typically available within 10–12 days, enabling timely clinical decisions during pregnancy or after birth.
2. How accurate is this FISH test compared to full karyotyping?
FISH achieves greater than 99% sensitivity specifically for chromosomes 18, X, and Y; however, it cannot detect structural rearrangements, rare aneuploidies, or unbalanced translocations. Full karyotyping or chromosomal microarray remains necessary for a comprehensive genomic assessment when clinically indicated.
3. Can I use insurance for this test and how is sample collection arranged?
Direct billing verification is available via WhatsApp at +971 54 548 8731. Prenatal sample collection (amniotic fluid or chorionic villus) must be performed at an accredited hospital facility under ultrasound guidance by a qualified obstetrician. Postnatal blood samples may be collected at our laboratory or at a partner clinic; home phlebotomy is not available for this test due to the invasive nature of primary specimen types.
UAE Regulatory & Data Privacy Adherence
This diagnostic service operates in full compliance with UAE federal data protection and healthcare regulations. All patient data is processed under Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Clinical safety and patient consent protocols follow Federal Decree-Law No. 4 of 2016 on Medical Liability. The laboratory holds ISO 9001:2015 Certification (INT/EGQ/2509DA/3139) and operates under DHA Facility License No. 1143.
Clinical & Logistical Metadata
| Test Name | FISH for Prenatal and Postnatal Diagnosis of Chromosomes 18, X, and Y |
| Price (AED) | 900 |
| Turnaround Time | 10–12 Days |
| Sample Type / Matrix | Prenatal (Amniotic Fluid, Chorionic Villus) / Postnatal (Peripheral Blood) – Hospital Extraction Only for invasive prenatal specimens |
| Methodology Used | Fluorescence In-Situ Hybridization (FISH) – Rapid Molecular Cytogenetics |
| ICD-10-CM Code | Z36.0 |
| LOINC Code | 32702-7 |
| DHA Facility License & Laboratory Address | DHA License No. 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | DNA Labs UAE |
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