Test Price
850 AED✅ Home Collection Available
SRY Gene FISH Test (Y Chromosome Microdeletion) in UAE | 850 AED | DHA-Compliant Diagnostics
Executive Summary & Core Metrics
- Accuracy: Diagnostic sensitivity exceeding 99.9% via ISO 9001:2015 certified processing (Cert: INT/EGQ/2509DA/3139).
- Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection available daily from 8 AM to 11 PM. Sample maintained strictly at 18–22°C in sodium heparin tube.
- Clinical Guidance: Post-test telephonic consultation with a Consultant Medical Genetics specialist to interpret results in clinical context.
- Insurance: Direct billing verification via WhatsApp at +971 54 548 8731.
Test Overview & Methodology
The SRY Gene FISH Test detects the presence of the sex-determining region Y (SRY) on the Y chromosome using fluorescently labeled DNA probes. This highly sensitive molecular cytogenetic assay is essential for evaluating disorders of sexual development (DSD), Turner syndrome mosaicism, and cryptic Y-chromosome rearrangements. Our DHA-licensed facility delivers rapid 4-day reports with ISO-certified cold-chain home collection, ensuring sample integrity throughout the diagnostic pathway.
| Feature | SRY FISH Test (Our Method) | Conventional Karyotyping |
|---|---|---|
| Target Precision | Locus-specific detection of SRY gene; identifies low-level mosaicism down to 1–5% | Whole chromosome analysis; may miss microdeletions or cryptic mosaicism |
| Methodology | Fluorescence In Situ Hybridization (FISH) on interphase and metaphase nuclei | Tissue culture, Giemsa banding, requires viable dividing cells |
| Turnaround Time | 4 working days | 14–21 days |
| Sample Stability | Sodium heparin tube; maintain at 18–22°C; do not freeze | Sodium heparin; time-sensitive viability; requires prompt processing |
Physician Insight & Safety Protocols
Lina Osama Zaki Quteineh | Consultant Medical Genetics | DHA Registration ID: 9294403 — “As your genetic specialist, I recognize that concerns about ambiguous genitalia or chromosomal disorders can be deeply unsettling for families. This highly sensitive FISH assay pinpoints the SRY gene with exceptional resolution, yet results must always be integrated with the full clinical picture — including ultrasound findings, hormonal profiles, and physical examination. My commitment is to guide you through every step, ensuring you receive not just a laboratory result, but a clear, compassionate, and actionable interpretation.”
Advisory: Medication Continuity
Do not discontinue or alter any prescribed medication without consulting your referring physician. This diagnostic test is an elective tool and does not replace ongoing clinical management or urgent medical care.
Exclusion Criteria & Emergency Red Flags
- Absolute Contraindication: This test is not intended for fetal sex selection for non-medical reasons. It must be ordered by a registered physician exclusively for clinical investigation of DSD or chromosomal anomalies.
- Specimen Rejection Criteria: Frozen samples, clotted blood, hemolyzed specimens, or missing mandatory Chromosome & FISH Requisition Form (Form 17) will lead to rejection. Ensure same-day collection and shipment maintained at 18–22°C per protocol.
- Emergency Alert: If the patient presents with acute adrenal crisis, severe electrolyte imbalance, or ambiguous genitalia accompanied by circulatory shock, seek emergency medical attention immediately. This test is an elective diagnostic tool and does not replace urgent clinical management.
Patient FAQ & Clinical Guidance
1. What is the purpose of the SRY FISH test?
This test detects the SRY gene on the Y chromosome using fluorescent DNA probes, enabling evaluation of ambiguous genitalia, Turner syndrome mosaicism, and sex chromosome abnormalities. It helps clinicians determine the presence of Y-chromosome material in individuals with discordant phenotypic sex, guiding diagnosis of conditions such as 46,XX testicular DSD or 45,X/46,XY mosaicism. Results must always be interpreted alongside hormonal profiles, imaging, and clinical examination.
2. How is the sample collected and what preparation is needed?
A simple blood draw in a sodium heparin (green-top) tube — no fasting required. Our VIP mobile phlebotomy team collects 5 mL (minimum 3 mL) of whole blood, maintaining the sample strictly at 18–22°C during transport. The mandatory Chromosome & FISH Requisition Form (Form 17) is completed at the time of collection. Avoid freezing the sample under any circumstances.
3. What does a positive SRY result indicate?
A positive SRY result confirms the presence of the SRY locus, indicating a Y-chromosome-containing cell line. This may confirm Y-chromosome material in mosaic Turner syndrome (45,X/46,XY) or explain testicular development in an XX individual (46,XX testicular DSD). However, a positive result alone does not define the clinical outcome — it must be integrated with phenotype, imaging, and hormonal assessment by a Consultant Medical Genetics specialist before any management decisions are made.
4. How should I prepare for the home collection visit?
No special preparation is required. Ensure the requisition form (Form 17) is completed and signed by your referring physician prior to collection. The phlebotomist will arrive with all necessary equipment, including the correct sodium heparin tube. Please keep the sample at room temperature (18–22°C) until the courier collects it — do not refrigerate or freeze.
5. When will I receive the results and how are they delivered?
Results are reported within 4 working days from sample receipt. A secure digital report is sent directly to your referring physician and is also available via our patient portal. A post-test telephonic consultation with our Consultant Medical Genetics specialist is included to explain the findings in clinical context and address any questions.
UAE Regulatory & Data Privacy Adherence
Regulatory Compliance: This laboratory service operates under DHA Facility License Number 1143 and is supervised by DHA-licensed professionals. All testing adheres to Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) for patient data privacy and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields for digital health information security. Clinical safety and patient consent protocols follow Federal Decree-Law No. 4 of 2016 on Medical Liability. Processing is performed in an ISO 9001:2015 certified facility (Cert: INT/EGQ/2509DA/3139). Direct billing insurance verification is available via WhatsApp at +971 54 548 8731.
Clinical & Logistical Metadata
| Test Name | SRY Gene FISH Test (Y Chromosome Microdeletion) |
| Price (AED) | 850 AED |
| Turnaround Time | 4 working days |
| Sample Type / Matrix | Peripheral whole blood (sodium heparin tube, green-top); 5 mL (3 mL minimum); maintain at 18–22°C; do not freeze |
| Methodology Used | Fluorescence In Situ Hybridization (FISH) on interphase and metaphase nuclei |
| ICD-10-CM Code | Q98.8 (Other specified sex chromosome abnormalities, male phenotype) |
| LOINC Code | 33776-2 (SRY gene targeted mutation analysis in Blood or Tissue by FISH) |
| DHA Facility License & Address | License No: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE — DNA Labs UAE |
دعم ثنائي اللغة متاح
التحقق من التغطية التأمينية
Check Insurance Coverage Instantly
Stop the guesswork. Send a photo of your Insurance Card and Doctor's Prescription to our DHA-Certified Verification Team on WhatsApp.
توقف عن التخمين. أرسل صورة من بطاقة التأمين ووصفة الطبيب إلى فريق التحقق المعتمد من هيئة الصحة بدبي عبر الواتساب. احصل على تحديث الحالة في دقائق.
Available in Arabic, English, Hindi & Urdu
ISMS 27001:2022
ISO Accredited
HIPAA
All reports reviewed by DHA-Certified physicians