Test Price
700 AED✅ Home Collection Available
Prader-Willi Syndrome (FISH) Genetic Testing in UAE | 700 AED | DHA Licensed
Executive Summary & Core Metrics
✅ 99.9% diagnostic sensitivity – ISO-accredited FISH processing delivering diagnostic sensitivity of 99.9% for the 15q11-q13 deletion.
✅ VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection – Available daily from 8 AM to 11 PM for peripheral whole blood samples; prenatal specimens (amniotic fluid, chorionic villi, cord blood) require hospital extraction.
✅ Telephonic post-test genetic counselling – DHA-licensed Consultant Medical Genetics provides result interpretation and family risk assessment.
✅ Insurance verification via WhatsApp – Send your insurance card to +971 54 548 8731 for immediate coverage confirmation.
Book Home Collection via WhatsAppTest Overview & Methodology
This FISH (Fluorescence In-Situ Hybridization) assay directly visualises the chromosome 15q11-q13 deletion responsible for more than 70 percent of Prader-Willi syndrome cases, providing a definitive genetic diagnosis in three to four business days. The test uses fluorescently labelled DNA probes that bind specifically to the target locus on chromosome 15, enabling direct microscopic detection of microdeletions that standard karyotyping cannot resolve.
| Feature | Our Test (FISH) | Closest Alternative (Methylation-Specific PCR) |
|---|---|---|
| Technique | Fluorescence In-Situ Hybridisation | DNA Methylation-Sensitive PCR |
| Resolution | Identifies 15q11-q13 deletion directly | Detects abnormal methylation, but cannot distinguish deletion from UPD |
| Sensitivity for Deletion Subtype | greater than 99.9 percent | greater than 99 percent (for all subtypes together) |
| Turnaround Time | 3-4 business days | 5-7 business days |
| Price in UAE | 700 AED | Variable (approximately 850 AED) |
This test is ordered when Prader-Willi syndrome is suspected based on neonatal hypotonia, feeding difficulties, characteristic facial features, and later hyperphagia. The three primary specialist groups referring patients are Clinical Geneticists, Pediatricians and Neonatologists, and Pediatric Endocrinologists.
Physician Insight & Safety Protocols
As a Consultant Medical Genetics specialist, I emphasise that FISH analysis for the 15q11-q13 deletion provides rapid and definitive confirmation of the most common genetic subtype of Prader-Willi syndrome. A negative FISH result does not exclude the diagnosis and should prompt reflex methylation-specific testing to detect maternal uniparental disomy. Early genetic confirmation is critical for initiating growth hormone therapy, nutritional management, and recurrence risk counselling. I strongly recommend that all results be interpreted within the full clinical context by a qualified genetics professional.
— Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Clinical Advisory – Medication Safety
Do not discontinue prescribed medication without consulting your doctor. Abrupt cessation of growth hormone or endocrine therapies may cause metabolic decompensation.
Exclusion Criteria & Emergency Red Flags
- Exclusion Criteria: Active vaginal bleeding, severe oligohydramnios, gestational age less than 10 weeks for chorionic villus sampling; severe neonatal coagulopathy for peripheral blood draw; known allergy to topical anaesthetics used for phlebotomy.
- ER Red Flags After Invasive Prenatal Collection: Sudden severe abdominal pain, fever above 38 degrees Celsius, leaking amniotic fluid, or heavy bleeding – proceed immediately to the nearest emergency department.
- All home blood collections are performed by DHA-licensed phlebotomists with full vital-sign monitoring and immediate cold-chain transport to the ISO-accredited central laboratory.
Patient FAQ & Clinical Guidance
1. How accurate is the Prader-Willi FISH test?
FISH for Prader-Willi syndrome detects the common 15q11-q13 deletion with over 99.9 percent diagnostic specificity, providing a definitive genetic confirmation in three to four days. False positive results are virtually zero because the probe binds exclusively to the target locus. In the event of a normal result, reflex methylation testing is automatically recommended by our clinical team at no additional charge to exclude maternal uniparental disomy.
2. Can this test be performed during pregnancy?
Yes, prenatal FISH can be performed on amniotic fluid from 15 weeks gestation or chorionic villi from 10 weeks gestation to rapidly rule out the deletion in high-risk pregnancies. The collection must be performed by an obstetrician in a hospital setting. Our team coordinates cold-chain transport to the laboratory, and results are available within three business days. Genetic counselling is provided before and after the procedure.
3. Do I need a doctor referral to take this test?
A valid doctor prescription is mandatory for diagnostic Prader-Willi FISH testing, except when performed for surgical clearance, pregnancy monitoring, or international travel health requirements. You can upload the prescription via WhatsApp for instant verification by our care team. Self-referred testing is not permitted under DHA regulations for genetic investigations involving minors.
UAE Regulatory & Data Privacy Adherence
All personal health information is processed in full compliance with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Explicit written consent is obtained before any genetic testing, and data are never shared without the patient explicit authorisation.
Clinical testing safety, patient consent, and medical liability are governed by Federal Decree-Law No. 4 of 2016 on Medical Liability, ensuring full legal protection for every diagnostic procedure.
The laboratory operates under DHA Facility License Number 1143 and maintains ISO 9001:2015 certification (Certificate: INT/EGQ/2509DA/3139). All genetic counselling services are delivered by DHA-registered practitioners.
Clinical & Logistical Metadata
| Test Name | Prader-Willi Syndrome (FISH) Genetic Testing |
| Price (AED) | 700 AED |
| Turnaround Time | 3-4 business days |
| Sample Type / Matrix | Peripheral Blood (EDTA), Amniotic Fluid, Chorionic Villi, Cord Blood |
| Methodology Used | Fluorescence In-Situ Hybridization (FISH) |
| ICD-10-CM Code | Q87.1 |
| LOINC Code | 26462-5 |
| DHA Facility License & Laboratory Address | DHA License: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | DNA Labs UAE |
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