Test Price
750 AED✅ Home Collection Available
PML/RARA Fusion Gene FISH Test (t(15;17)) in UAE | 750 AED | DHA Licensed
Executive Summary & Core Metrics
This advanced genetic FISH assay delivers definitive diagnosis of Acute Promyelocytic Leukemia (APL) by detecting the PML/RARA fusion gene with a diagnostic sensitivity of 99.9%, validated within our ISO 9001:2015 accredited laboratory. The service includes temperature-controlled home phlebotomy (daily 8 AM to 11 PM) by certified nursing staff and a complimentary post-result teleconsultation for clinical interpretation. Total cost: 750 AED, with direct insurance facilitation available via WhatsApp at +971 54 548 8731. Minors require legal guardian consent per Federal Decree-Law No. 4 of 2016 on Medical Liability.
TRUST Licensed by the Dubai Health Authority – Facility License No. 1143
Test Overview & Methodology
The fluorescence in‑situ hybridization (FISH) assay detects the reciprocal translocation t(15;17)(q24;q21) that generates the PML/RARA fusion oncogene — the defining molecular hallmark of Acute Promyelocytic Leukemia (APL). This method provides rapid genetic confirmation within 4 working days, directly guiding targeted therapy with all‑trans retinoic acid (ATRA) and arsenic trioxide, which dramatically improve survival outcomes. The test is performed on peripheral whole blood or bone marrow aspirate using dual‑color break‑apart probes validated for clinical diagnostic use.
| Feature | Our PML/RARA FISH Test | Standard Reference Lab FISH |
|---|---|---|
| Diagnostic Sensitivity | 99.9% (ISO‑validated dual‑color probes) | ~97% (generic single‑color probes) |
| Turnaround Time | 4 working days (same‑day specimen processing) | 7–10 working days |
| Post‑Test Clinical Support | Complimentary tele‑consultation with a consultant medical geneticist | Often unavailable or billed separately |
| Pre‑analytical Logistics | Temperature‑controlled home collection (18–22°C), no cold‑chain deviation | Courier with variable temperature adherence |
| Accreditation | ISO 9001:2015 + DHA Facility License 1143 | May lack UAE‑specific regulatory oversight |
Physician Insight & Safety Protocols
“A positive PML/RARA FISH result constitutes a hematological emergency requiring immediate intervention due to the high risk of disseminated intravascular coagulation. This highly sensitive FISH assay is the gold standard for rapid genetic confirmation, yet it must always be correlated with the peripheral blood smear, coagulation profile, and clinical context — a positive result alone does not distinguish APL from rare 15;17 variant translocations. Because early death from hemorrhage remains the greatest threat, initiation of ATRA should not be delayed while awaiting confirmatory studies. Our laboratory integrates rigorous probe validation with strict temperature‑controlled logistics to preserve cell viability and ensure result accuracy.”
— Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Advisory: Medication Safety & Clinical Precautions
Important Caution
Do not discontinue any prescribed therapy — especially anticoagulants, antiplatelet agents, or chemotherapy — without explicit consultation with your treating oncologist. Abrupt cessation can precipitate fatal bleeding, leukostasis, or differentiation syndrome. Always inform your healthcare team that APL is suspected before any procedural intervention.
Exclusion Criteria & Emergency Flags
Pre‑Collection Exclusion Criteria
- Active bleeding diathesis or platelet count <20,000/µL — collection requires specialist assistance.
- Known hypersensitivity to sodium heparin — an alternative anticoagulant tube must be arranged.
- Uncontrolled severe hypertension (BP >180/110 mmHg) — home phlebotomy may be deferred to a clinical setting.
- Incomplete Chromosome & FISH Requisition (Form 17) — the specimen will not be processed.
Urgent ER Presentation Signs
- Sudden extensive bruising, petechial rash, or persistent oozing from venipuncture sites.
- New‑onset visual disturbances, severe headache, or focal neurological deficit — rule out intracranial hemorrhage.
- Unexplained fever with dyspnea — consider differentiation syndrome.
- Signs of deep vein thrombosis in a limb with recent bone marrow biopsy.
If you experience any of these symptoms before scheduled collection, call 998 for ambulance transport to the nearest emergency department and inform staff that APL is suspected.
Patient FAQ & Clinical Guidance
1. How quickly can I receive the PML/RARA FISH test result in the UAE?
Our ISO‑accredited laboratory delivers the final report within 4 working days from sample receipt, enabling immediate therapeutic intervention for APL. The pre‑analytical phase — home collection and transport at controlled 18–22°C — is optimized to avoid delays. In critical cases, a verbal preliminary result can be communicated to your hematologist within 48 hours upon request.
2. What sample types are needed and how must they be handled?
A minimum of 3 mL of peripheral whole blood or 2 mL of bone marrow aspirate is collected in two sodium heparin (green‑top) tubes, kept strictly at 18–22°C and never frozen. The accompanying Chromosome & FISH Analysis Requisition (Form 17) is mandatory to ensure accurate patient identification and clinical indication. Heparin preserves cell viability for hybridization; freezing or extreme heat renders the specimen unacceptable. Bone marrow aspiration is performed exclusively in a hospital setting.
3. Why is FISH preferred over PCR for initial APL diagnosis?
FISH provides rapid, cell‑level visualization of the t(15;17) translocation with a near‑100% positive predictive value for APL, avoiding the longer turnaround time and potential false‑negative rates of PCR in variant breakpoint regions. Moreover, FISH can be performed on both bone marrow and peripheral blood, offering flexibility in critically ill patients. PCR is reserved for minimal residual disease monitoring after remission is achieved.
UAE Regulatory & Data Privacy Adherence
Data Protection & Health Information Governance: This service fully complies with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. All patient data is encrypted during transmission and storage, processed exclusively within DHA‑licensed facilities, and accessed only by authorized clinical personnel.
Clinical Safety & Consent: Patient consent and clinical safety protocols adhere to Federal Decree-Law No. 4 of 2016 on Medical Liability, ensuring that all procedures — including home phlebotomy and genetic testing — are performed with full informed consent and medico‑legal accountability.
ISO Accreditation: ISO 9001:2015 – Certificate INT/EGQ/2509DA/3139. All laboratory processes are subject to internal audit and external quality assessment programs.
Clinical & Logistical Metadata
| Test Name | PML/RARA Fusion Gene FISH (t(15;17)) |
| Price (AED) | 750 AED |
| Turnaround Time | 4 Working Days |
| Sample Type / Matrix | Peripheral Whole Blood (3 mL) or Bone Marrow Aspirate (2 mL) — Sodium Heparin Tubes |
| Methodology Used | Fluorescence In‑Situ Hybridization (FISH) — Dual‑Color Break‑Apart Probe |
| ICD-10-CM Code | C92.4 |
| LOINC Code | 60511-1 |
| DHA Facility License & Laboratory Address | DHA License No. 1143 — Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | DNA Labs UAE |
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