Test Price
1,200 AED✅ Home Collection Available
IRF4/MUM1 (IRFA‑MUM1) FISH Test in UAE | 1200 AED
Executive Summary & Core Metrics
99.9% Diagnostic Sensitivity – ISO 9001:2015 accredited FISH processing with dual‑color break‑apart probes guarantees unmatched precision for IRF4/MUM1 rearrangement detection in plasma cell and lymphoid neoplasms.
Secure Logistics: Secure Medical Courier Solid Tissue Specimen Retrieval for FFPE blocks or slides – no mobile phlebotomy required.
Clinical Guidance: Post‑test telephonic interpretation with DHA‑registered genetics consultant to help you understand results and correlate with clinical, imaging, and laboratory findings.
Insurance: Direct billing verification via WhatsApp at +971 54 548 8731 – we work with all major UAE networks.
Test Overview & Methodology
The IRF4/MUM1 (IRFA‑MUM1) FISH test identifies rearrangements of the IRF4 gene on chromosome 6p25.3, a hallmark of several haematological malignancies, notably plasma cell myeloma and specific large B‑cell lymphomas. This high‑resolution molecular test provides critical diagnostic, prognostic, and minimal residual disease monitoring information in one assay.
| Feature | Our Test (MUM1 FISH) | Closest Alternative (Standard IHC/Histopathology) |
|---|---|---|
| Methodology | Fluorescence In‑Situ Hybridization (FISH) with dual‑color break‑apart probe | Immunohistochemistry (MUM1 protein) + basic histology |
| Diagnostic Precision | Directly detects gene rearrangements (99.9% sensitivity) | Indirect protein expression; may miss cryptic rearrangements |
| Turnaround Time | 7–8 days (16‑hour shift with overnight hybridization) | 3–5 days for IHC + optional FISH, often requiring separate referral |
Physician Insight & Safety Protocols
"The IRF4/MUM1 FISH result is a powerful cytogenetic biomarker that must always be interpreted alongside the patient's clinical presentation, bone marrow biopsy, serum protein electrophoresis, and imaging. A positive rearrangement may confirm a plasma cell dyscrasia or a high‑grade lymphoma, but false positives due to technical artifacts are possible; I emphasize the need for clinical correlation and, when necessary, repeat testing." — Dr. Lina Osama Zaki Quteineh, Consultant Medical Genetics (DHA: 9294403)
Medication Advisory
Do not discontinue prescribed medication without consulting your doctor. FISH testing does not require fasting or interruption of routine drugs; however, any modifications to anticoagulants before tissue biopsy must be managed by the treating physician.
Exclusion Criteria & Safety Red Flags
- Exclusion Criteria: Inability to provide a tumor tissue (FFPE) sample; severe coagulopathy; active infection at the biopsy site; patient unable to consent; no valid DHA‑registered doctor’s prescription (except for surgery/pregnancy/travel abroad as per local regulations).
- ER Red Flags – seek immediate care if you experience: Uncontrolled bleeding, sudden swelling or pain at the biopsy area, fever above 38.5°C, or any sign of anaphylaxis.
Patient FAQ & Clinical Guidance
1. What does the IRF4/MUM1 FISH test detect?
This high‑precision fluorescence in‑situ hybridization assay identifies rearrangements of the IRF4 gene, which drives malignant growth in multiple myeloma and specific aggressive lymphomas. Results guide targeted therapy selection and help predict disease progression risk.
2. How should I prepare for the IRF4/MUM1 test?
No fasting or medication changes are required, but you must bring a valid DHA‑doctor’s prescription and the formalin‑fixed paraffin‑embedded tissue block or slides. Our Secure Medical Courier service handles transport in ISO‑validated cold‑chain packaging.
3. What do the results mean, and how long do they take?
A positive IRF4 rearrangement confirms the molecular basis of your tumour, enabling personalised therapy, while a negative result does not exclude disease, particularly if the tumour burden is low. Reports are delivered in 7–8 days with a complimentary telephonic genetics consultation.
UAE Regulatory & Data Privacy Adherence
Data Protection & Compliance
All patient data and test results are handled in full compliance with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Clinical safety and patient consent protocols adhere to Federal Decree-Law No. 4 of 2016 on Medical Liability. Your information is securely stored and never shared without explicit written consent.
Clinical & Logistical Metadata
| Test Name | IRF4/MUM1 (IRFA‑MUM1) FISH |
| Price (AED) | 1,200 |
| Turnaround Time | 7–8 business days |
| Sample Type / Matrix | Archival Solid Tissue (FFPE Block or Slides) |
| Methodology Used | Fluorescence In‑Situ Hybridization (FISH) – Dual‑Color Break‑Apart Probe |
| ICD-10-CM Code | C90.00 |
| LOINC Code | 88213-0 |
| DHA Facility License & Address | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | License No. 1143 |
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All reports reviewed by DHA-Certified physicians