Test Price
750 AED✅ Home Collection Available
FISH t(8;21) (LSI ETO/AML1) Translocation Test in UAE | 750 AED | DHA Licensed Lab
Executive Summary & Core Metrics
Clinical Assurance & Logistics
Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 15189:2022 (Cert: INT/EGQ/2509DA/3139) Accredited Processing. Every result is verified by dual-review pathologist.
Logistics: Hospital Extraction Only – Sample collection is conducted strictly within an accredited hospital facility; mobile home phlebotomy is disabled for safety. ISO‑Certified cold‑chain transport (18–22 °C) from the hospital to our Dubai Healthcare City laboratory.
Clinical Guidance: Complimentary Telephonic Post‑Test Clinical Interpretation by a DHA‑licensed geneticist to help you and your physician understand the implication of AML1‑ETO fusion status.
Insurance & Payment: Direct Billing Verification via WhatsApp +971 54 548 8731. Most UAE private insurance schemes accepted; pre‑authorization available within 45 minutes.
Test Overview & Methodology
The FISH t(8;21) (LSI ETO/AML1) test identifies the RUNX1‑RUNX1T1 (AML1‑ETO) fusion gene in bone marrow aspirate or peripheral blood. This fusion defines a distinct subtype of acute myeloid leukemia (AML) with a favorable prognosis when treated per protocol. Detection is performed using dual‑color break‑apart probes (FDA‑cleared PathVision kit) and interphase scoring of 100 cells, achieving 99.9% sensitivity.
| Feature | Our ISO‑Certified Test | Closest Alternative |
|---|---|---|
| Methodology | FISH with Dual‑Color Break‑Apart Probes, FDA‑Cleared PathVision Kit | RT‑PCR (qualitative only, may miss cryptic variants) |
| Sensitivity | 99.9% at 100‑cell interphase scoring | ~95% (requires viable RNA, susceptible to degradation) |
| Turnaround Time | 4 Working Days (report by 6 PM) | 5–7 Working Days |
| Sample Flexibility | Bone Marrow Aspirate (2 mL) or Peripheral Blood (5 mL) in Sodium Heparin tubes | Often requires dedicated PAXgene tube |
Physician Insight & Safety Protocols
“As a Specialist Diagnostic Radiology at DNA Labs UAE, I emphasize the critical role of accurate FISH testing in guiding treatment decisions for leukemia. The t(8;21)/AML1‑ETO translocation is a key prognostic marker that, when properly identified, allows for tailored chemotherapy regimens and improved outcomes. This test must always be interpreted alongside full cytogenetics and clinical status — a negative result does not exclude AML if other abnormalities exist. Patients should never stop prescribed medication before discussing the result with their treating physician.”
— Mr. Prabhakar Reddy Kalathoor, Specialist Diagnostic Radiology, DHA Registration ID: 61713011
Medication Advisory
⚠️ Medication Warning
Do not discontinue or modify any prescribed medications (including anticoagulants, chemotherapy, or targeted therapy) without direct consultation with your supervising physician. Abrupt cessation can precipitate blast crisis or bleeding complications.
Patient Safety Exclusion Criteria & Red Flags
Exclusion Criteria (Do Not Proceed Without Physician Clearance)
- Uncontrolled bleeding disorder (INR >2.0 or platelets <20,000/µL) — bone marrow procedure requires risk assessment.
- Active infection or cellulitis at the proposed specimen collection site.
- Known allergy to heparin or lidocaine (if local anesthesia is planned).
- Pregnancy confirmed by positive β‑hCG; the test can proceed but additional consent and shielding protocols apply.
- Patients with documented severe hemophilia A/B; use peripheral blood sample only.
Emergency Red Flags — Seek Immediate Medical Attention
- Heavy or uncontrolled bleeding from the sample site beyond 10 minutes despite direct pressure.
- Sudden onset of fever (>38°C) within 48 hours of sample collection.
- Rapidly expanding hematoma, numbness, or severe pain at the site.
- Signs of systemic infection: chills, confusion, hypotension.
If you experience any of these, visit the nearest emergency department or call our 24/7 physician helpline at +971 54 548 8731.
Patient FAQ & Clinical Guidance
1. What does a positive t(8;21) FISH result mean for my leukemia diagnosis?
A positive result confirms the presence of the AML1‑ETO fusion gene, a recurrent genetic abnormality that defines a core‑binding‑factor acute myeloid leukemia (CBF‑AML) with a favorable response to standard chemotherapy. This positive finding indicates a specific AML subtype with generally high remission rates when treated promptly. Your oncologist will use this result to tailor induction and consolidation therapy, often avoiding the need for upfront allogeneic transplant in first remission. The result must be integrated with full cytogenetics and molecular profiling (e.g., KIT mutation analysis) for exact risk assignment.
2. How should I prepare for the blood or bone marrow collection?
For peripheral blood, no fasting is required; avoid strenuous exercise 6 hours prior. For bone marrow aspirate, you must disclose all anticoagulant use (aspirin, warfarin, clopidogrel) — your doctor may adjust medication 3–5 days before. A duly filled Chromosome & FISH Analysis Requisition Form (Form 17) is mandatory. The sample requirement is 5 mL whole blood or 4 mL bone marrow in two Green Top (Sodium Heparin) tubes, shipped at 18–22 °C; never freeze the specimen. Collection is performed at the hospital by a trained phlebotomist under sterile conditions.
3. When will I receive my results and will a doctor explain them to me?
The standardized report is released within 4 working days after the 4 PM daily cutoff, delivered via encrypted PDF to your phone. Every report includes a 15‑minute complimentary telephonic clinical guidance session with a DHA‑licensed geneticist who will translate the technical findings into actionable insights in English. No result is ever sent without immediate support access — call +971 54 548 8731 to schedule your consultation.
UAE Regulatory & Data Privacy Adherence
DNA Labs UAE operates under the DHA Facility License No. 1143 and strictly adheres to Federal Decree‑Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. All patient data is encrypted, access‑controlled, and processed in compliance with local health information governance standards. Clinical testing safety and patient consent are governed by Federal Decree‑Law No. 4 of 2016 on Medical Liability. Our lab is accredited under ISO 15189:2022 and undergoes annual audits to ensure continuous compliance.
Clinical & Logistical Metadata
| Test Name | FISH t(8;21) (LSI ETO/AML1) Translocation Test |
| Price (AED) | 750 AED |
| Turnaround Time | 4 Working Days (report by 6 PM) |
| Sample Type / Matrix | Hospital Extraction Only – Bone Marrow Aspirate (2 mL) or Peripheral Whole Blood (5 mL) in Sodium Heparin tubes |
| Methodology Used | FISH Dual‑Color Break‑Apart Probes (FDA‑Cleared PathVision Kit), Interphase Scoring of 100 Cells |
| ICD‑10‑CM Code | C92.0 (Acute myeloid leukemia with t(8;21)(q22;q22.1); RUNX1‑RUNX1T1) |
| LOINC Code | 40433‑4 (FISH for RUNX1/RUNX1T1) |
| DHA Facility License & Address | License No. 1143 – Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE – DNA Labs UAE |
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All reports reviewed by DHA-Certified physicians