Test Price
750 AED✅ Home Collection Available
FISH t(8;21) (LSI ETO/AML1) Translocation Test in UAE | 750 AED | 2026 DHA Guidelines
تحليل FISH للنقل الصبغي t(8;21) (ETO/AML1) في الإمارات | 750 درهم | معتمد من هيئة الصحة بدبي 2026
Executive Summary & Clinical Assurance
Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 15189:2022 (Cert: INT/EGQ/2509DA/3139) Accredited Processing. Every result is verified by dual-review pathologist.
Premium Logistics: Paid Hospital-Grade Home Collection with ISO-Certified Cold-Chain Transport (18–22°C) and VIP Mobile Phlebotomy within 2 hours across Dubai, Abu Dhabi, Sharjah. Sample stability guaranteed.
Clinical Guidance: Complimentary Telephonic Post-Test Clinical Interpretation by a DHA-licensed molecular geneticists to help you and your physician understand the implication of AML1-ETO fusion status.
Insurance & Payment: Direct Billing Verification via WhatsApp +971 54 548 8731. Most UAE private insurance schemes accepted; pre-authorization available within 45 minutes.
ملخص تنفيذي بالعربية: اختبار التهجين الموضعي الفلوري (FISH) للكشف عن نقل صبغي t(8;21) – المعروف بجين الاندماج AML1-ETO – هو معيار تشخيصي أساسي وفقًا لإرشادات هيئة الصحة بدبي 2026. عينة الدم أو نخاع العظم تُحلل بدقة 99.9% تحت إشراف خبراء أمراض الدم والأورام. خدمة السحب المنزلي متاحة مع استشارة سريرية تكميلية بعد النتيجة.
Test Overview & Clinical Utility
The FISH t(8;21) (LSI ETO/AML1) test identifies the RUNX1-RUNX1T1 (AML1-ETO) fusion gene in blood or bone marrow, defining a distinct subtype of acute myeloid leukemia (AML) with favorable prognosis when treated per protocol.
يكشف هذا التحليل عن اندماج جيني ETO/AML1 المرتبط بابيضاض الدم النقوي الحاد ذي الإنذار الجيد، مما يساعد في تصنيف المرض وتوجيه العلاج وفق أحدث بروتوكولات 2026.
| Feature | Our ISO-Certified Test | Closest Alternative |
|---|---|---|
| Methodology | FISH with Dual-Color Break-Apart Probes, FDA-Cleared PathVision Kit | RT-PCR (qualitative only, may miss cryptic variants) |
| Sensitivity | 99.9% at 100-cell interphase scoring | ~95% (requires viable RNA, susceptible to degradation) |
| Turnaround Time | 4 Working Days (report by 6 PM) | 5–7 Working Days |
| Sample Flexibility | Whole Blood or Bone Marrow (2x Sodium Heparin tubes) | Often requires dedicated PAXgene tube |
Physician Insight & Medication Safety
“As a DHA-licensed consultant haematopathologist, I emphasize that the presence of t(8;21)/AML1-ETO fusion confirms a subtype of AML that, when treated with modern anthracycline-based induction, carries a long-term survival exceeding 60%. However, this test must always be interpreted alongside morphology, karyotype, and clinical status — a negative result does not exclude AML if other abnormalities exist. Patients should never stop prescribed medication before discussing the result with their treating physician.”
— Dr. PRABHAKAR REDDY, Consultant Haematopathologist, DHA License: 61713011
⚠️ Medication Warning
Do not discontinue or modify any prescribed medications (including anticoagulants, chemotherapy, or targeted therapy) without direct consultation with your supervising physician. Abrupt cessation can precipitate blast crisis or bleeding complications.
Patient Safety Exclusion Criteria & Red Flags
Exclusion Criteria (Do Not Proceed Without Physician Clearance)
- Uncontrolled bleeding disorder (INR >2.0 or platelets <20,000/µL) — bone marrow procedure requires risk assessment.
- Active infection or cellulitis at the proposed specimen collection site.
- Known allergy to heparin or lidocaine (if local anesthesia is planned).
- Pregnancy confirmed by positive β-hCG; the test can proceed but additional consent and shielding protocols apply.
- Patients with documented severe hemophilia A/B; use peripheral blood sample only.
Emergency Red Flags — Seek Immediate Medical Attention
- Heavy or uncontrolled bleeding from the sample site beyond 10 minutes despite direct pressure.
- Sudden onset of fever (>38°C) within 48 hours of sample collection.
- Rapidly expanding hematoma, numbness, or severe pain at the site.
- Signs of systemic infection: chills, confusion, hypotension.
If you experience any of these, visit the nearest emergency department or call our 24/7 physician helpline at +971 54 548 8731.
Patient FAQ & Bilingual Clinical Guidance
1. What exactly does a positive t(8;21) FISH result mean for my leukemia diagnosis?
A positive result confirms the presence of the AML1-ETO fusion gene, a recurrent genetic abnormality that defines a core-binding-factor acute myeloid leukemia (CBF-AML) with a favorable response to standard chemotherapy. This 15-word snippet clarifies: A positive t(8;21) FISH indicates a specific AML subtype with generally high remission rates when treated promptly. Your oncologist will use this result to tailor induction and consolidation therapy, often avoiding the need for upfront allogeneic transplant in first remission. The must be integrated with full cytogenetics and molecular profiling (e.g., KIT mutation analysis) for exact risk assignment.
سؤال بالعربية: ماذا تعني نتيجة FISH الإيجابية للنقل الصبغي t(8;21) لتشخيص اللوكيميا؟
الإجابة المختصرة: نتيجة إيجابية لاندماج AML1-ETO تؤكد ابيضاض الدم النقوي الحاد من النوع ذي الإنذار الجيد، مما يوجّه إلى علاج كيميائي محدد دون حاجة لزراعة فورية.
2. How should I prepare for the blood or bone marrow collection?
For peripheral blood, no fasting is required; avoid strenuous exercise 6 hours prior. For bone marrow aspirate, you must disclose all anticoagulant use (aspirin, warfarin, clopidogrel) — your doctor may adjust medication 3–5 days before. A duly filled Chromosome & FISH Analysis Requisition Form (Form 17) is mandatory. The sample requirement is 5 mL whole blood or 4 mL bone marrow in two Green Top (Sodium Heparin) tubes, shipped at 18–22°C; never freeze the specimen. Our VIP phlebotomist will arrive with all necessary documentation, ensuring chain-of-custody compliance.
سؤال: كيف أستعد لسحب العينة (دم أو نخاع عظمي)؟
الإجابة: لا تحتاج إلى صيام، مع وجوب الإفصاح عن مميعات الدم؛ يُشترط إحضار نموذج الطلب الخاص (Form 17) المعبأ بالكامل.
3. When will I receive my results and will a doctor explain them to me?
The standardized report is released within 4 working days after the 4 PM daily cutoff, delivered via encrypted PDF to your phone. Every report includes a 15-minute complimentary telephonic clinical guidance session with a DHA-licensed geneticist who will translate the technical findings into actionable insights in English or Arabic. No result is ever sent without immediate support access — call +971 54 548 8731 to schedule your consultation.
سؤال: متى سأحصل على النتيجة وهل سيشرحها لي طبيب؟
الإجابة: تظهر النتيجة خلال 4 أيام عمل، مع استشارة هاتفية مجانية من أخصائي وراثة معتمد من هيئة الصحة بدبي.
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توقف عن التخمين. أرسل صورة من بطاقة التأمين ووصفة الطبيب إلى فريق التحقق المعتمد من هيئة الصحة بدبي عبر الواتساب. احصل على تحديث الحالة في دقائق.
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All reports reviewed by DHA-Certified physicians