Test Price
750 AED✅ Home Collection Available
FISH for Monosomy 7 / del(7q31) in AML & MDS in UAE | 750 AED | 2026 DHA Guidelines
تحليل FISH للكشف عن أحادي الصبغي 7 / حذف (7q31) في ابيضاض الدم النقوي الحاد ومتلازمة خلل التنسج النقوي في الإمارات | 750 درهم | معتمد من هيئة الصحة بدبي
Executive Summary – UAE Trust & Precision
يضمن هذا الفحص الجيني الدقيق تشخيصًا جزيئيًا موثوقًا لابيضاض الدم النقوي الحاد ومتلازمة خلل التنسج النقوي مع طفرة حذف الذراع الطويل للكروموسوم 7.
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015 Accredited Processing (Cert: INT/EGQ/2509DA/3139).
- Premium Logistics: Paid Hospital-Grade Home Collection via ISO Certified Cold-Chain Home Collection and VIP Mobile Phlebotomy.
- Clinical Guidance: Telephonic Post-Test Clinical Guidance in result interpretation.
- Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.
Test Overview
The FISH Monosomy 7 / del(7q31) test precisely detects loss of chromosome 7 material in bone marrow or blood using fluorescent DNA probes, providing critical prognostic stratification in adult acute myeloid leukaemia (AML) and myelodysplastic syndromes (MDS). The result directly guides risk‑adapted therapy, including the need for allogeneic stem cell transplant.
يكشف اختبار FISH عن فقدان الكروموسوم 7 أو حذف المنطقة 7q31، وهو علامة جزيئية عالية الأهمية في تصنيف وتوجيه علاج ابيضاض الدم النقوي الحاد ومتلازمة خلل التنسج النقوي.
| Parameter | Our Test (ISO 9001:2015) | Conventional Karyotyping |
|---|---|---|
| Detection Method | Interphase FISH with validated locus‑specific probes (D7S486 at 7q31, D7Z1 centromere) | Cell culture & microscopic chromosome analysis |
| Diagnostic Sensitivity (del(7q) / monosomy 7) | 99.9% analytical sensitivity for targeted loci | ~85–90% (culture failure or low mitotic index limits detection) |
| Turnaround Time | 4 working days after sample receipt | 10–14 days (cell culture dependent) |
| Clinical Utility | Directly reports clonal aberrations; actionable for immediate treatment planning | May miss non‑dividing clones; requires mitotic activity |
Physician Insight & Safety Protocol
“As a haematopathologist licensed in Dubai, I stress that FISH results for monosomy 7 / del(7q) must always be interpreted alongside bone marrow morphology and clinical history. A positive finding signals a high‑risk AML/MDS profile, but your treatment plan should only be amended following a multi‑disciplinary team discussion. Never discontinue prescribed medication without consulting your treating physician.”
— Dr. PRABHAKAR REDDY, Specialist Haematopathologist, DHA License 61713011
⚠️ Critical Medication Advisory:
Do not discontinue prescribed medication without consulting your doctor. Certain drugs (e.g., immunosuppressants, iron chelators) may influence bone marrow cellularity, but only your consultant can determine safe management. No test preparation overrides clinical judgement.
⛑️ Patient Safety – Exclusion Criteria & When to Seek Emergency Care
- Bone Marrow Aspirate Exclusion: Uncorrected severe coagulopathy (INR >1.5, platelets <30 ×10⁹/L), active infection over the posterior iliac crest, or inability to lie prone for the procedure.
- Peripheral Blood Collection Caution: Severe anaemia (Hb <7 g/dL) causing dizziness or haemodynamic instability – consider supervised collection.
- Emergency Red Flags: If you experience persistent heavy bleeding, purulent discharge from the collection site, fever >38.5°C, or severe worsening pain post‑bone marrow collection, attend the nearest Emergency Department immediately.
- All samples must be transported at 18–22°C; DO NOT FREEZE. Duly filled Chromosome & FISH analysis Requisition Form (Form 17) is mandatory.
Patient FAQ & Clinical Guidance
1. What is the FISH Monosomy 7 / del(7q31) test used for?
Key Clinical Snippet: This fluorescence in‑situ hybridization test identifies loss of chromosome 7 or deletion at band 7q31 to classify AML/MDS risk and guide urgent treatment decisions.
It aids haematologists in confirming a myelodysplastic or leukaemic clone carrying the unfavourable −7/del(7q) abnormality. The result influences whether chemotherapy alone is sufficient or allogeneic stem cell transplantation must be considered early.
سؤال: ما هو تحليل FISH للكشف عن أحادي الصبغي 7/ حذف 7q31؟
الإجابة: يكشف هذا الاختبار عن فقدان الكروموسوم 7 أو حذف المنطقة 7q31، مما يساعد على تصنيف خطورة ابيضاض الدم النقوي الحاد ومتلازمة خلل التنسج النقوي وتوجيه العلاج.
2. How should I prepare for the FISH, and what samples are required?
Key Clinical Snippet: No fasting or special preparation is needed; a 5 mL whole blood or 4 mL bone marrow sample in a sodium heparin green‑top tube is collected without freezing.
For home collection, our VIP mobile phlebotomy team arrives with cooled transport containers. Ensure you have filled in the mandatory Chromosome & FISH Requisition Form (Form 17) before the visit. Inform the team of any bleeding tendency or anticoagulant use to confirm eligibility for bone marrow aspiration.
سؤال: كيف أستعد لاختبار FISH لأحادي الصبغي 7؟
الإجابة: لا يلزم صيام أو استعداد خاص، حيث يتم سحب عينة دم أو نخاع عظمي في أنبوب الهيبارين الصوديومي، مع ضرورة تقديم نموذج طلب التحليل المخصص.
3. What do positive or negative results mean, and how quickly will I receive my report?
Key Clinical Snippet: A positive FISH result for monosomy 7 or del(7q31) indicates an adverse genetic risk group in AML/MDS that typically requires intensified therapy, while a negative result helps exclude this high‑risk marker.
Reports are delivered within 4 working days after the sample reaches the laboratory. A written interpretation and a call from our clinical team explain the implications, but final management decisions rest with your haematologist‑oncologist. Urgent verbal notification is provided for critical results.
سؤال: ماذا تعني النتائج الإيجابية أو السلبية لاختبار FISH لأحادي الصبغي 7؟
الإجابة: النتيجة الإيجابية تدل على وجود خلل جيني عالي الخطورة يتطلب علاجًا مكثفًا، بينما تستبعد النتيجة السلبية هذا العلامة الوراثية غير المواتية.
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