Test Price
750 AED✅ Home Collection Available
FISH for Monosomy 7 / del(7q31) in AML & MDS – Precision Diagnostic in Dubai
Executive Summary & Core Metrics
- Test Name: FISH – Monosomy 7 / del(7q31) for Acute Myeloid Leukaemia (AML) & Myelodysplastic Syndromes (MDS)
- Price: 750 AED
- Turnaround Time: 4 working days from sample receipt
- Sample Type: Bone marrow aspirate or peripheral whole blood (sodium heparin)
- Methodology: Interphase fluorescence in situ hybridization (FISH) with locus-specific probes D7S486 (7q31) and D7Z1 (centromere)
- Accuracy Guarantee: 99.9 % diagnostic sensitivity via ISO 9001:2015 accredited processing
- Clinical Guidance: Telephonic post-test clinical interpretation included
- Insurance: Direct billing verification via WhatsApp +971 54 548 8731
Test Overview & Methodology
The FISH Monosomy 7 / del(7q31) test precisely detects loss of chromosome 7 material using fluorescent DNA probes that hybridize to the 7q31 locus and the centromeric region of chromosome 7. This molecular cytogenetic analysis provides critical prognostic stratification in adult acute myeloid leukaemia (AML) and myelodysplastic syndromes (MDS), directly guiding risk-adapted therapy including the need for allogeneic stem cell transplant.
Unlike conventional karyotyping, interphase FISH does not require dividing cells, enabling detection of deletions in non-mitotic populations. This yields superior sensitivity for clonal aberrations, particularly in samples with low blast counts or poor culture growth.
| Parameter | FISH Assay (Locus-Specific) | Conventional Karyotyping |
|---|---|---|
| Detection Method | Interphase FISH with validated D7S486 (7q31) and D7Z1 (centromere) probes | Cell culture & Giemsa-banded microscopic analysis |
| Diagnostic Sensitivity for del(7q)/monosomy 7 | 99.9 % analytical sensitivity for targeted loci | ~85–90 % (culture failure or low mitotic index limits detection) |
| Turnaround Time | 4 working days after sample receipt | 10–14 days (culture dependent) |
| Clinical Utility | Reports clonal aberrations directly; actionable for immediate treatment planning | May miss non-dividing clones; requires mitotic activity |
Physician Insight & Safety Protocols
“As a Consultant Medical Genetics practicing in Dubai Healthcare City, I emphasise that FISH results for monosomy 7 / del(7q) must always be integrated with bone marrow morphology, complete blood counts, and the patient’s clinical trajectory. A positive finding identifies a high-risk AML/MDS genetic profile, yet any change in therapy requires a formal multi-disciplinary team discussion. Patients should never adjust or discontinue prescribed treatment based solely on a genetic test result.”
— Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Critical Patient Advisory – When to Seek Emergency Care
- Bone Marrow Aspirate Exclusion: Uncorrected severe coagulopathy (INR >1.5, platelets <30 ×10⁹/L), active infection over the posterior iliac crest, or inability to lie prone for the procedure.
- Peripheral Blood Collection Caution: Severe anaemia (Hb <7 g/dL) causing haemodynamic instability – supervised collection recommended.
- Emergency Red Flags: Persistent heavy bleeding, purulent discharge from collection site, fever >38.5 °C, or severe worsening pain post-procedure – attend the nearest Emergency Department immediately.
- All samples must be transported at 18–22 °C; DO NOT FREEZE. A completed Chromosome & FISH Analysis Requisition Form (Form 17) is mandatory for processing.
Important Pre-Test Consideration
No specific dietary preparation is required. However, patients receiving anticoagulant therapy or with known bleeding disorders must inform the clinical team before bone marrow aspiration. The treating haematologist should be consulted if there is any uncertainty regarding the safety of the procedure.
Patient FAQ & Clinical Guidance
1. What is the FISH Monosomy 7 / del(7q31) test used for?
Key Clinical Snippet: This fluorescence in situ hybridization test identifies loss of chromosome 7 or deletion at band 7q31 to classify AML/MDS risk and guide urgent treatment decisions.
It aids haematologists in confirming a myelodysplastic or leukaemic clone carrying the unfavourable −7/del(7q) abnormality. The result influences whether conventional chemotherapy is sufficient or whether allogeneic stem cell transplantation should be considered early in the disease course.
2. How should I prepare for this test and what samples are needed?
Key Clinical Snippet: No fasting or special preparation is required; a 5 mL whole blood or 4 mL bone marrow sample collected in a sodium heparin (green-top) tube is suitable. Do not freeze the specimen.
For bone marrow collection, the procedure must be performed in a hospital setting under sterile conditions by an experienced clinician. For peripheral blood collection, our VIP mobile phlebotomy team can visit your home daily between 8 AM and 11 PM with temperature-controlled transport. Ensure the Chromosome & FISH Requisition Form (Form 17) is completed before collection.
3. What do positive or negative results mean and when will I receive my report?
Key Clinical Snippet: A positive result for monosomy 7 or del(7q31) indicates an adverse genetic risk group in AML/MDS that typically warrants intensified therapy, while a negative result helps exclude this high-risk marker.
Reports are issued within 4 working days after the sample reaches the laboratory. A written molecular report along with a telephonic explanation from our clinical genetics team will clarify the implications. Urgent verbal notification is provided for critical results, but all final management decisions must be made by your treating haematologist-oncologist.
UAE Regulatory & Data Privacy Adherence
DNA Labs UAE operates in full compliance with the UAE Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Clinical safety and patient consent procedures adhere strictly to Federal Decree-Law No. 4 of 2016 on Medical Liability. All genetic data is encrypted, access-controlled, and never disclosed to third parties without explicit written patient consent.
The laboratory is ISO 9001:2015 certified (Cert. INT/EGQ/2509DA/3139) and licensed by the Dubai Health Authority (DHA) for high-complexity molecular cytogenetic testing. Patients retain full rights to access, rectify, and request deletion of their personal health information under PDPL.
Clinical & Logistical Metadata
| Parameter | Detail |
|---|---|
| Test Name | FISH for Monosomy 7 / del(7q31) in AML & MDS |
| Price (AED) | 750 |
| Turnaround Time | 4 working days |
| Sample Type / Matrix | Bone marrow aspirate or peripheral whole blood (sodium heparin). Hospital extraction required for marrow collection; VIP mobile phlebotomy available for blood draw daily 8 AM – 11 PM. |
| Methodology Used | Interphase Fluorescence In Situ Hybridization (FISH) with D7S486 (7q31) and D7Z1 (centromere) probes |
| ICD-10-CM Code | C92.00 (Acute myeloid leukaemia), D46.9 (Myelodysplastic syndrome, unspecified) |
| LOINC Code | 82195-0 (del(7q31) [Presence] in Blood or Marrow by FISH) |
| DHA Facility License & Laboratory Address | License No. 1143 — Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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