Test Price
1,800 AED✅ Home Collection Available
FISH for HER2/neu Gene Amplification Test in Dubai | 1800 AED | DHA Certified
Executive Summary & Core Metrics
Core Diagnostic Highlights
- Accuracy Guarantee: 99.9% diagnostic sensitivity via ISO 15189 accredited molecular pathology processing.
- Specimen Logistics: Secure Medical Courier Solid Tissue Specimen Retrieval – hospital extraction only; sample collection is conducted strictly within an accredited hospital facility.
- Clinical Guidance: Telephonic post-test clinical guidance for result interpretation and targeted therapy planning.
- Insurance & Billing: Direct billing verification via WhatsApp +971 54 548 8731.
Test Overview & Methodology
The FISH for HER2/neu test precisely quantifies HER2 gene amplification in formalin-fixed paraffin-embedded (FFPE) tumor tissue, guiding targeted therapy decisions for breast and gastric cancers. This dual-probe fluorescence in-situ hybridization assay provides a quantitative gene copy number ratio (HER2/CEP17) that determines eligibility for anti-HER2 therapeutics such as trastuzumab and pertuzumab.
| Feature | Our FISH Test | IHC (Alternative) |
|---|---|---|
| Method | Fluorescence In-Situ Hybridization (dual-probe) | Immunohistochemistry (protein expression) |
| Precision | Gold standard; quantitative gene copy number | Semi-quantitative; subjective scoring |
| Turnaround Time | 10–12 days | 3–5 days |
| Price | 1800 AED | ~600 AED (variable) |
Physician Insight & Safety Protocols
"As a DHA-licensed diagnostic radiologist, I emphasize that HER2 FISH results must always be interpreted alongside full histopathology findings and imaging correlation. A confirmed amplified status can unlock eligibility for trastuzumab-based regimens, but the clinical context of tumor grade, nodal involvement, and receptor status must be integrated for optimal treatment planning."
— Mr. Prabhakar Reddy Kalathoor, Specialist Diagnostic Radiology, DHA Registration ID: 61713011
Advisory Notice for Patients and Clinicians
Important Clinical Guidance
Test results are a component of the complete diagnostic picture and should not be used in isolation to initiate or alter therapy. All treatment decisions, including the use of anti-HER2 agents, require multidisciplinary review and documented patient consent. Do not discontinue or modify prescribed medications without consulting your treating physician.
Exclusion Criteria & Red Flags
- Insufficient tumor content (<10%) may lead to inconclusive results; a repeat biopsy or core needle re-sampling may be required.
- Inadequate formalin fixation or extensive necrotic tissue compromises FISH signal integrity and assay accuracy.
- If the HER2 FISH ratio falls in the equivocal range (1.8–2.2), reflex testing with alternative HER2 assessment methods and oncologist consultation is mandatory.
- Emergency: If you experience severe pain, bleeding, or signs of infection at the biopsy site following tissue extraction, seek immediate medical attention.
Patient FAQ & Clinical Guidance
1. What is the purpose of the HER2 FISH test?
Snippet Answer: The HER2 FISH test measures HER2 gene copy number in breast or gastric cancer tissue to determine eligibility for targeted therapy with trastuzumab and related anti-HER2 agents. A positive amplification result supports the use of these precision oncology treatments.
2. How is the specimen collected for this test?
Snippet Answer: No new patient procedure is required. The test is performed on an existing formalin-fixed paraffin-embedded (FFPE) tissue block or archival biopsy slide obtained during prior surgical resection or diagnostic biopsy. The specimen is retrieved via Secure Medical Courier Solid Tissue Specimen Retrieval from the hospital pathology department.
3. What do HER2 FISH results indicate?
Snippet Answer: A positive (amplified) result indicates an elevated HER2 gene copy number, predicting a high likelihood of response to anti-HER2 drugs. A negative (non-amplified) result suggests low HER2 gene dosage, where alternative therapeutic pathways may be more appropriate. Equivocal results require further reflex testing and specialist consultation.
4. How long does it take to receive results?
Snippet Answer: The standard turnaround time is 10 to 12 business days from specimen receipt at the laboratory. This duration accounts for tissue processing, hybridization, microscopic enumeration, and sign-out by a qualified pathologist.
UAE Regulatory & Data Privacy Adherence
Data Protection & Regulatory Framework
Your clinical data and genetic information are processed in full compliance with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. All laboratory procedures adhere to Federal Decree-Law No. 4 of 2016 on Medical Liability to ensure patient safety and informed consent protocols.
DNA Labs UAE holds DHA Facility License Number 1143 and operates under ISO 15189 standards for medical laboratory quality and competence. Your test data is encrypted, access-controlled, and never shared with third parties without explicit written authorization.
Clinical & Logistical Metadata
| Test Name | FISH for HER2/neu Gene Amplification (Dual-Probe) |
| Price (AED) | 1800 AED |
| Turnaround Time | 10–12 business days |
| Sample Type / Matrix | Formalin-Fixed Paraffin-Embedded (FFPE) Tissue Block / Archival Biopsy Specimen |
| Methodology Used | Fluorescence In-Situ Hybridization (FISH) – Dual-Probe HER2/CEP17 |
| ICD-10-CM Code | C50.9, C16.9, Z51.0 |
| LOINC Code | 21630-8 |
| DHA Facility License & Address | License: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE – DNA Labs UAE |
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