Test Price
850 AED✅ Home Collection Available
FGFR1 (8p12) Gene Rearrangement (FISH) Test in UAE | 850 AED | DHA Licensed
Executive Summary & Core Metrics
Test Overview & Methodology
This fluorescence in‑situ hybridization (FISH) assay employs dual‑color break‑apart probes targeting the FGFR1 gene locus at chromosome 8p12. The test delivers definitive detection of FGFR1 rearrangements associated with myeloid/lymphoid neoplasms with eosinophilia (M/LN‑eo), guiding the selection of targeted tyrosine kinase inhibitor therapy such as pemigatinib. Results are reported as the percentage of nuclei with a split signal pattern among 200 interphase cells.
| Feature | Our FGFR1 FISH | Conventional Cytogenetics |
|---|---|---|
| Diagnostic Precision | 99.9% Sensitivity | ~85% detection; limited by culture failure |
| Methodology | Break‑apart FISH (FGFR1‑specific dual‑color probes) | G‑banded karyotyping, 5‑Mb resolution |
| Turnaround | 4 working days | 7–10 working days |
| Price | 850 AED | 1,200 AED and above |
Physician Insight & Safety Protocols
A note from Lina Osama Zaki Quteineh (Consultant Medical Genetics, DHA Registration ID: 9294403)
A positive FGFR1 rearrangement alters the therapeutic landscape entirely. Rather than broad‑spectrum chemotherapy, patients become candidates for FGFR1‑selective TKIs that spare off‑target toxicity. I always emphasise that this molecular result must be integrated with the bone marrow morphology, eosinophil count and clinical history before treatment decisions are finalised.
Patient Safety & Exclusion Criteria
- Exclusion: Acute medical emergencies requiring immediate hospitalisation; haemodynamic instability; active severe coagulopathy (INR > 2.0, platelets < 20 × 10⁹/L without transfusion support).
- Urgent ER referral if you experience: sudden high fever (> 38.5 °C), uncontrolled bleeding, severe unexplained bone pain, or new neurological deficits before your scheduled collection.
- Bone marrow collection: Performed only under physician supervision; prior clinical evaluation mandatory.
Patient FAQ & Clinical Guidance
1. What does a positive FGFR1 rearrangement indicate?
An FGFR1 rearrangement detected by FISH confirms the presence of 8p11 myeloproliferative syndrome, a rare myeloid/lymphoid neoplasm with eosinophilia. This result opens the door to targeted therapy with FGFR1‑selective tyrosine kinase inhibitors such as pemigatinib, which can significantly improve outcomes compared with conventional chemotherapy.
2. How should I prepare for the blood or bone marrow sample collection?
No fasting is required for peripheral blood collection. For bone marrow aspiration, follow your haematologist’s pre‑procedure instructions precisely, including any temporary cessation of anticoagulants. Ensure the Chromosome & FISH request form is completed accurately before the procedure.
3. Can this test be used to monitor treatment response?
Yes. Serial FGFR1 FISH testing at defined intervals can detect minimal residual disease and confirm molecular remission after targeted therapy. A decline in the percentage of rearranged nuclei over time correlates with treatment efficacy and guides timely dose adjustments or regimen changes.
4. Is the FGFR1 FISH test covered by health insurance in the UAE?
Most comprehensive UAE health insurance plans cover FISH testing for confirmed or suspected haematological malignancies. We offer direct billing verification via WhatsApp at +971 54 548 8731. Please have your policy number and pre‑approval letter ready for swift processing.
UAE Regulatory & Data Privacy Adherence
Data Protection: All patient genetic data are processed in full compliance with Federal Decree‑Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Results are transmitted via encrypted channels and stored on ISO‑certified secure servers within the UAE.
Clinical Safety & Consent: Specimen collection, handling and reporting adhere to the standards of Federal Decree‑Law No. 4 of 2016 on Medical Liability. Written informed consent is obtained before any invasive bone marrow procedure.
Licensure: DNA Labs UAE operates under DHA Facility License No. 1143 and maintains ISO 15189 accreditation for molecular cytogenetic testing.
Clinical & Logistical Metadata
| Test Name | FGFR1 (8p12) Gene Rearrangement by FISH |
| Price (AED) | 850 AED |
| Turnaround Time | 4 working days |
| Sample Type / Matrix | Peripheral Blood (whole blood, EDTA) or Bone Marrow Aspirate. VIP Mobile Phlebotomy & Temperature‑Controlled Cold‑Chain Home Collection available for peripheral blood (8 AM–11 PM daily). Bone marrow extraction requires a hospital visit. |
| Methodology Used | Dual‑colour break‑apart fluorescence in‑situ hybridization (FISH) on interphase nuclei; 200‑cell analysis with ISO 15189 quality controls. |
| ICD‑10‑CM Code | D47.5 (Chronic eosinophilic leukaemia / hypereosinophilic syndrome) |
| LOINC Code | 92888‑9 (FGFR1 gene rearrangement [Presence] in Blood or Tissue by FISH) |
| DHA Facility License & Address | DNA Labs UAE – License No. 1143. Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE. |
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