Test Price
700 AEDโ Home Collection Available
CRLF2 Gene Rearrangement (CML, AML, ALL) FISH Test โ DHA Licensed Molecular Cytogenetics in Dubai
Executive Summary & Core Metrics
UAE Trust & Clinical Excellence โ Certified Molecular Diagnostics
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015 Accredited Processing (Cert: INT/EGQ/2509DA/3139).
- Clinical Logistics: Hospital Extraction Only โ Sample collection is conducted strictly within an accredited hospital facility; mobile home phlebotomy is disabled for safety.
- Clinical Guidance: Complimentary Telephonic Post-Test Clinical Guidance with result interpretation by a DHA-licensed Consultant Medical Genetics specialist.
- Insurance: Direct Billing Verification via WhatsApp at +971 54 548 8731.
This CRLF2 FISH assay delivers rapid, high-resolution detection of gene rearrangements critical for risk stratification and targeted therapy selection in acute lymphoblastic leukemia, chronic myeloid leukemia, and acute myeloid leukemia. All procedures comply with DHA regulatory standards and federal health data protection frameworks.
Test Overview & Methodology
The CRLF2 Gene Rearrangement FISH Test is a cytogenetic assay designed to detect structural rearrangements of the CRLF2 gene located on the pseudoautosomal region of chromosomes X and Y. These rearrangements are recurrent molecular abnormalities in B-cell acute lymphoblastic leukemia (ALL), particularly the Philadelphia chromosome-like (Ph-like) subtype, and are also observed in subsets of chronic myeloid leukemia (CML) and acute myeloid leukemia (AML). Identification of a CRLF2 rearrangement informs risk classification, guides the use of targeted therapies such as JAK inhibitors, and supports prognostic counselling.
The test employs fluorescence in-situ hybridization (FISH) using locus-specific break-apart or dual-fusion probes, enabling direct visualization of gene rearrangements in interphase or metaphase nuclei. This method provides superior spatial resolution compared to conventional karyotyping and does not require cultured cells, yielding results within a 3โ4 day window. All processing occurs under ISO 9001:2015 certified protocols at our Dubai Healthcare City laboratory.
| Feature | Our CRLF2 FISH Test (DHA-Certified) | Closest Alternative (PCR / Karyotyping) |
|---|---|---|
| Precision | High diagnostic sensitivity with locus-specific probes capable of detecting cryptic rearrangements | May miss cryptic rearrangements; PCR requires prior knowledge of fusion partners; karyotyping dependent on metaphase quality |
| Methodology | Fluorescence In-Situ Hybridization (FISH) โ ISO 9001:2015 accredited, direct visualization at single-cell resolution | Real-time PCR (lower spatial resolution, no single-cell analysis) or conventional karyotyping (requires viable cells, longer culture time) |
| Turnaround Time | 3โ4 days | Typically 7โ10 days (karyotyping) or 5โ7 days (PCR with confirmation) |
| Sample Requirement | Peripheral blood or bone marrow; minimal volume (2โ3 mL blood or 0.5โ1 mL bone marrow) | PCR: purified nucleic acid; karyotyping: viable, dividing cells from fresh sample |
Physician Insight & Safety Protocols
โAs a DHA-licensed Consultant Medical Genetics specialist, I want to emphasise that the CRLF2 FISH test provides a critical molecular clue for haematological malignancies, but it must always be interpreted within the full clinical pictureโincluding complete blood count, bone marrow morphology, immunophenotyping, and other cytogenetic markers. A positive rearrangement indicates an actionable genetic target, but it is not a standalone diagnosis. Never adjust or discontinue any prescribed therapy without direct consultation with your treating oncologist. If you experience new symptoms such as unexplained bruising, persistent fever, or profound fatigue, seek immediate medical evaluation. Your safety and accurate diagnosis remain our highest priority.โ
โ Lina Osama Zaki Quteineh, Consultant Medical Genetics | DHA Registration ID: 9294403
Important Advisory for Patients
Medication Continuity: Do not stop or alter any prescribed medications, including anticoagulants or targeted therapies, unless explicitly directed by your physician. The CRLF2 FISH result is one component of a comprehensive diagnostic workup and should never be used in isolation to guide treatment decisions.
Clinical Correlation Required: This test requires a valid doctorโs prescription. Results are released only to the referring physician and are accompanied by an interpretive report that must be reviewed in the context of your complete medical history.
Exclusion Criteria & Emergency Red Flags
- Hospital-Only Collection: Sample collection for this assay is performed exclusively within accredited hospital facilities. Mobile home phlebotomy is not available due to the invasive nature of the required specimen (bone marrow aspiration or peripheral blood draw under controlled conditions).
- Contraindications: Active bleeding disorder or ongoing anticoagulant therapy requires medical supervision during collection. If the collection site shows signs of infection, severe pain, or haematoma formation, postpone the procedure and consult your physician.
- Emergency Symptoms: Seek immediate emergency care if you experience high fever (โฅ38.5ยฐC), uncontrolled bleeding, sudden severe bone pain, shortness of breath, or loss of consciousness after sample collection.
- Regulatory Compliance: All genetic data is handled in accordance with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Clinical safety and patient consent are governed by Federal Decree-Law No. 4 of 2016 on Medical Liability.
Patient FAQ & Clinical Guidance
1. What does a positive CRLF2 FISH result indicate?
A positive CRLF2 rearrangement indicates an abnormal gene fusion commonly found in Philadelphia chromosome-like acute lymphoblastic leukemia (Ph-like ALL) and in subsets of myeloid leukaemias. This molecular finding helps your oncologist refine the risk classification, select targeted therapies such as JAK inhibitors, and monitor treatment response. It is not a definitive cancer diagnosis on its own but a critical molecular marker that must be integrated with other clinical and laboratory findings.
2. How is the sample collected and what are the risks?
Sample collection is performed exclusively within a hospital setting by trained medical personnel. For peripheral blood, a standard venipuncture is used with minimal discomfort. If a bone marrow aspirate is required, the procedure is performed under local anaesthesia with sterile technique. The primary risks include minor bruising, transient discomfort at the puncture site, and, very rarely, infection or bleeding. Your clinical team will monitor you throughout the procedure to ensure safety.
3. Is the CRLF2 FISH test covered by UAE health insurance?
Most UAE health insurers provide coverage for this test when it is medically indicated and prescribed by a licensed oncologist or haematologist with documented clinical suspicion. We offer direct billing verification via WhatsApp at +971 54 548 8731; simply send a photo of your insurance card for an immediate pre-approval assessment. Coverage confirmation is typically provided within one business day.
4. How long does it take to receive results?
The standard turnaround time is 3 to 4 business days from sample receipt at our laboratory. Results are delivered electronically to your referring physician along with a detailed interpretive report. In urgent clinical scenarios, expedited processing can be arranged upon request from the treating doctor.
UAE Regulatory & Data Privacy Adherence
Your Genetic Data is Protected Under UAE Federal Law
DNA Labs UAE operates under the oversight of the Dubai Health Authority (DHA Facility License No. 1143) and complies fully with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL). All genetic information derived from the CRLF2 FISH test is classified as sensitive personal data and is processed, stored, and transmitted using encryption and access-control measures that meet or exceed regulatory requirements.
Our laboratory information management system enforces role-based access, audit logging, and data minimisation principles. No genetic data is shared with third parties without your explicit written consent, except as required by law or for public health reporting in de-identified aggregate form. The use of information and communication technology in health fields is governed by Federal Law No. 2 of 2019, and all clinical procedures adhere to the standards of care established under Federal Decree-Law No. 4 of 2016 on Medical Liability.
For any data privacy inquiries or to exercise your rights under PDPL (including access, rectification, and erasure), please contact our Data Protection Officer at privacy@dnalabs.ae or via WhatsApp at +971 54 548 8731.
Clinical & Logistical Metadata
| Test Name | CRLF2 Gene Rearrangement (CML, AML, ALL) FISH Test |
| Price (AED) | 700 |
| Turnaround Time | 3โ4 Business Days |
| Sample Type / Matrix | Peripheral Blood or Bone Marrow (Hospital Extraction Only) |
| Methodology Used | Fluorescence In-Situ Hybridization (FISH) โ ISO 9001:2015 |
| ICD-10-CM Code | C91.00, C92.00, C92.10 |
| LOINC Code | 69247-7 |
| DHA Facility License & Laboratory Address | DHA License No. 1143 โ Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | DNA Labs UAE |
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All reports reviewed by DHA-Certified physicians