Test Price
700 AED✅ Home Collection Available
PDGFRα (HES) FISH Analysis in UAE – 700 AED | Diagnostic Genetic Test
Executive Summary & Core Metrics
- Clinical Precision: 99.9% diagnostic sensitivity via ISO 15189 accredited laboratory detecting FIP1L1-PDGFRA rearrangement.
- Targeted Therapy Guidance: Positive result confirms eligibility for imatinib (Gleevec) in hypereosinophilic syndrome (HES) and chronic eosinophilic leukemia (CEL).
- Turnaround Time: Results within 3–4 working days from sample receipt.
- Price: 700 AED inclusive of report and clinical interpretation.
Test Overview & Methodology
PDGFRα (HES) FISH analysis detects the FIP1L1-PDGFRA gene fusion on chromosome 4q12, a definitive biomarker for imatinib-responsive myeloid neoplasms. Fluorescence in situ hybridization (FISH) directly visualizes the rearrangement in interphase cells, providing higher specificity than PCR-based assays for low-level clones. This test is routinely ordered when eosinophilia >1.5 × 10⁹/L is unexplained.
| Feature | Our FISH Test | PCR-Based Assay |
|---|---|---|
| Clinical Precision | Direct visualization of fusion in single cells | Amplifies DNA; may miss low-level clones |
| Methodology | Fluorescence In-Situ Hybridization | Reverse Transcriptase PCR |
| Turnaround Time | 3 – 4 days | 5 – 7 days |
| Sample Requirements | Bone marrow aspirate or peripheral blood | Bone marrow preferred |
| Cost (AED) | 700 | 850 – 1,200 |
Physician Insight & Safety Protocols
“A positive PDGFRα rearrangement must be correlated with complete blood count, clinical symptoms, and bone marrow morphology to confirm diagnosis of FIP1L1-PDGFRA-positive myeloid neoplasm. Targeted therapy with imatinib should only be initiated under haematology guidance. This FISH test provides the definitive biomarker for that decision.” — Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID 9294403.
Advisory & Pre-Test Requirements
- A valid doctor’s prescription is mandatory for this genetic test (except for pregnancy-related cases or international travel screening).
- Hospital Extraction Only – Sample collection is conducted strictly within an accredited hospital facility; mobile home phlebotomy is disabled for safety due to bone marrow aspirate requirement.
- Turnaround time: 3–4 working days after sample receipt.
- Direct billing verification to insurance via WhatsApp at +971 54 548 8731.
Safety Exclusion Criteria & Emergency Red Flags
- Severe uncorrected coagulopathy or active bleeding disorder precludes bone marrow aspirate.
- Known allergy to local anaesthetics used for skin preparation.
- Inability to lie still for the procedure due to pain or movement disorders.
- Seek immediate emergency care if you develop sudden high fever, severe bleeding, or rapid deterioration of organ function after the test.
Patient FAQ & Clinical Guidance
1. What is the PDGFRα (HES) FISH test used for?
This FISH analysis detects FIP1L1-PDGFRA gene fusion, essential for imatinib therapy selection in hypereosinophilic syndrome. It identifies the rearrangement on chromosome 4q12, confirming eligibility for targeted treatment and ruling out other eosinophilic disorders.
2. How is the sample collected?
A bone marrow aspirate or peripheral blood draw is performed by a qualified clinician in a hospital setting. For blood draws, a standard venipuncture is used. The sample is transported under cold-chain to our ISO-certified laboratory.
3. What is the turnaround time for results?
Results are typically available within 3–4 working days from sample receipt. A comprehensive report with clinical interpretation is provided electronically.
4. Do I need a prescription for this test?
Yes, a valid prescription from a licensed physician is required, unless the test is for pregnancy-related evaluation or international travel health clearance.
5. Can I have the test done at home?
No. Due to the potential need for bone marrow aspirate, sample collection must be performed in an accredited hospital facility. This ensures patient safety and sample integrity.
6. Are there any risks or side effects?
For bone marrow aspirate, risks include pain, bleeding, and infection at the puncture site. For a blood draw, minor bruising may occur. Both procedures are performed under strict safety protocols.
UAE Regulatory & Data Privacy Adherence
DNA Labs UAE complies with all UAE healthcare data protection laws. All genetic information is handled under:
- Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) – governing the processing of personal data.
- Federal Law No. 2 of 2019 concerning the use of information and communication technology in health fields.
- Federal Decree-Law No. 4 of 2016 on Medical Liability – ensuring clinical safety and informed consent.
Your results are confidential and shared only with you and your referring physician. Direct billing and insurance verification are available via WhatsApp +971 54 548 8731. DHA Facility License: 1143.
Clinical & Logistical Metadata
| Test Name | PDGFRα (HES) FISH Analysis |
| Price (AED) | 700 |
| Turnaround Time | 3 – 4 working days |
| Sample Type / Matrix | Bone marrow aspirate or peripheral blood (EDTA tube) |
| Methodology Used | Fluorescence In-Situ Hybridization (FISH) |
| ICD-10-CM Code | D72.1 (Eosinophilia) – also D47.3 (HES), C94.7 (CEL) |
| LOINC Code | 61309-8 (PDGFRA gene rearrangement by FISH) |
| DHA Facility License & Address | License 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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