FISH for Prenatal & Postnatal Diagnosis – Chromosomes 13 & 22 in UAE | 900 AED

Executive Summary & Core Metrics

This advanced molecular cytogenetic assay utilizes Fluorescence In-Situ Hybridization (FISH) technology for rapid, precise detection of chromosome 13 and 22 abnormalities in both prenatal and postnatal settings. The test is performed under strict DHA compliance, delivering 99.9% diagnostic sensitivity via ISO 9001:2015 accredited processing. Sample collection for invasive prenatal specimens is conducted strictly within an accredited hospital facility; mobile home phlebotomy is disabled for safety. Post-test clinical guidance is available via telephone, and insurance billing verification can be obtained through WhatsApp at +971 54 548 8731.

99.9% Diagnostic Sensitivity ISO 9001:2015 Certified Processing

Hospital Extraction Only DHA-Licensed Specialists for Invasive Sampling

Post-Test Clinical Guidance Telephonic Result Interpretation

Insurance Verification WhatsApp: +971 54 548 8731

Test Overview & Methodology

The FISH (Fluorescence In-Situ Hybridization) assay for chromosomes 13 and 22 is a targeted molecular cytogenetic test designed for the rapid detection of aneuploidies and microdeletions in prenatal amniotic fluid, chorionic villus samples, or postnatal blood specimens. This test provides critical diagnostic information for conditions including Patau syndrome (Trisomy 13) and 22q11.2 deletion syndrome (DiGeorge/VCFS), delivering actionable results within 10 to 12 working days.

Parameter	Our FISH Test (DHA-Accredited)	Conventional Karyotyping (Alternative)
Precision & Resolution	Locus-specific probe hybridization; detects submicroscopic deletions (e.g., 22q11.2) with high sensitivity	5–10 Mb resolution; may miss microdeletions below cytogenetic detection threshold
Methodology	Fluorescence In-Situ Hybridization (FISH) – targeted DNA probe technology	G-banded metaphase chromosome analysis requiring cell culture
Turnaround Time	10–12 working days	14–21 calendar days (culture-dependent)
Sample Types	Amniotic Fluid, Chorionic Villus Sample (CVS), Peripheral Blood	Amniotic Fluid, CVS, Peripheral Blood (viable cells required)
Price (AED)	900 AED	1,200–1,800 AED (variable)

Physician Insight & Safety Protocols

Lina Osama Zaki Quteineh (Consultant Medical Genetics, DHA Registration ID: 9294403) states: "The FISH assay for chromosomes 13 and 22 provides rapid, targeted genetic information that must always be interpreted within the full clinical context. A negative result does not exclude all chromosomal abnormalities, and a positive result warrants comprehensive genetic counseling. I urge every patient to discuss results thoroughly with their referring physician before making any clinical decisions."

Medication Advisory

Medication Warning

Do not discontinue any prescribed medication or alter your treatment regimen without consulting your treating physician. This genetic test is diagnostic in nature and does not replace ongoing clinical management.

Exclusion Criteria & Emergency Red Flags

Exclusion Criteria (Do Not Proceed Without Physician Clearance)

Active vaginal bleeding in pregnancy (second or third trimester)
Suspected or confirmed placental abruption
Multiple gestation with uncertain chorionicity (for CVS sampling)
Documented maternal coagulopathy or anticoagulant therapy not yet cleared for invasive sampling
Known uterine anomaly that precludes safe amniocentesis access
Untreated maternal urinary tract infection or chorioamnionitis

Post-Procedure ER Red Flags – Seek Immediate Medical Attention

Severe or worsening abdominal pain unrelieved by rest
Heavy vaginal bleeding (soaking more than one pad per hour)
Fever exceeding 38°C (100.4°F) or chills
Persistent leakage of clear fluid per vaginam (suggestive of amniotic fluid leak)
Uterine contractions or cramping at regular intervals
Signs of infection at the needle insertion site

Patient FAQ & Clinical Guidance

1. What does the FISH test for chromosomes 13 and 22 detect, and why is it recommended during pregnancy?

Answer: This advanced molecular cytogenetic test rapidly identifies numerical and structural abnormalities of chromosomes 13 and 22 using fluorescent DNA probes, enabling early detection of Patau syndrome (Trisomy 13) and 22q11.2 deletion syndrome. It is typically recommended when prenatal ultrasound reveals structural anomalies, when maternal serum screening indicates elevated risk, or when there is a known family history of chromosomal rearrangements involving these chromosomes.

2. How long does it take to receive FISH test results in the UAE, and what factors might affect turnaround time?

Answer: Standard turnaround time for FISH chromosome 13 and 22 analysis is 10 to 12 working days from sample receipt at our ISO-accredited laboratory. Factors that may extend this timeline include suboptimal sample quality requiring repeat hybridization, incomplete consent documentation (Forms 17 and 18), or the need for confirmatory testing when borderline signal patterns are observed. Our team proactively communicates any delays via your registered contact method.

3. Is fasting or any special preparation required before providing a sample for the FISH prenatal test?

Answer: No fasting is required; however, a duly completed Prenatal Genetic Testing Consent Form and Chromosome Analysis Requisition Form are mandatory before sample collection. For invasive procedures such as amniocentesis or chorionic villus sampling, your obstetrician will provide specific pre-procedural instructions including medication adjustments, bladder status requirements, and activity restrictions in the 24 hours preceding the collection.

UAE Regulatory & Data Privacy Adherence

✔ All patient genetic data is processed and stored in strict accordance with the Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL), ensuring end-to-end encryption and restricted access protocols.
✔ Compliance with Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields for secure digital health data handling.
✔ Laboratory accredited under ISO 9001:2015 (Certificate: INT/EGQ/2509DA/3139) with DHA Facility License 1143.
✔ Methodology verified against current clinical standards; FISH remains the gold-standard targeted molecular cytogenetic technique for rapid interphase aneuploidy screening, with locus-specific probe sensitivity exceeding 98% for chromosomes 13 and 22.

Clinical & Logistical Metadata

Test Name	FISH Prenatal & Postnatal Diagnosis – Chromosomes 13 & 22
Price (AED)	900 AED
Turnaround Time	10–12 working days
Sample Type / Matrix	Amniotic Fluid, Chorionic Villus Sample (CVS), Peripheral Blood Hospital Extraction Only – Sample collection is conducted strictly within an accredited hospital facility; mobile home phlebotomy is disabled for safety.
Methodology Used	Fluorescence In-Situ Hybridization (FISH) – targeted DNA probe hybridization
ICD-10-CM Code	Q91.7, Q93.81
LOINC Code	53744-6
DHA Facility License & Laboratory Address	DHA License No: 1143, DNA Labs UAE, Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE