MAPK10 Gene Epileptic Encephalopathy, Lennox‑Gastaut Type Genetic Test in UAE | 2800 AED

Executive Summary & Core Metrics

Trusted Genetic Diagnostics for Your Peace of Mind

Accuracy Guarantee: 99.9% diagnostic sensitivity via ISO‑accredited next‑generation sequencing.
Premium Logistics: VIP Mobile Phlebotomy & Temperature‑Controlled Cold‑Chain Home Collection available daily from 8 AM to 11 PM.
Clinical Guidance: Telephonic post‑test clinical guidance included in result interpretation.
Insurance: Direct billing verification via WhatsApp +971 54 548 8731.

Test Overview & Methodology

The MAPK10 Gene Epileptic Encephalopathy, Lennox‑Gastaut Type Genetic Test employs next‑generation sequencing (NGS) to detect pathogenic variants in the MAPK10 gene, a known cause of severe childhood‑onset epileptic encephalopathy. This advanced molecular test enables definitive diagnosis, targeted anti‑epileptic management, and informed genetic counselling for affected families. Our ISO‑accredited laboratory in Dubai Healthcare City ensures reliable results with comprehensive bioinformatic analysis.

Feature	Our Test (NGS)	Alternative (Sanger Sequencing)
Methodology	Next‑generation sequencing – full gene coverage, CNV detection	Sanger sequencing – single‑exon target, no CNV
Turnaround Time	3–4 weeks	6–8 weeks
Diagnostic Yield	>95% (coding + regulatory regions)	~70% (misses deep intronic/structural variants)
Sample Type	Whole blood, DNA, or FTA card	Blood or extracted DNA
Cost	2,800 AED	2,200–2,500 AED

Physician Insight & Safety Protocols

Insight from Lina Osama Zaki Quteineh Consultant Medical Genetics | DHA: 9294403

“This test provides families with a precise molecular explanation for their child’s epilepsy, guiding both treatment and prognosis. Always discuss results with a specialist who can integrate genetic findings with the full clinical picture.”

Important Advisory

Do not discontinue or alter prescribed anti‑epileptic medications without consulting the treating neurologist. Genetic test results are for diagnostic guidance and do not replace emergency care for acute seizures.

Exclusion Criteria & Emergency Red Flags

This test is not performed on minors without informed parental or legal guardian consent, in accordance with Federal Decree‑Law No. 4 of 2016 on Medical Liability.
Not a substitute for emergency diagnosis – acute seizure management must not be delayed pending genetic results.
Patients who are haemodynamically unstable or with suspected status epilepticus require immediate hospital evaluation.

🔴 EMERGENCY RED FLAGS: Prolonged convulsions (>5 minutes), loss of consciousness, respiratory distress, or severe allergic reaction – proceed to the nearest ER without delay.

Patient FAQ & Clinical Guidance

1. Who should consider this test?

This test is recommended for patients with Lennox‑Gastaut syndrome or epileptic encephalopathy of unknown origin, especially when clinical evaluation and EEG suggest a genetic cause. It uses next‑generation sequencing to identify MAPK10 mutations, enabling precise diagnosis and individualised care.

2. How is the test performed?

A blood sample or extracted DNA is collected through our VIP home phlebotomy service or at our Dubai Healthcare City lab. We accept whole blood, extracted DNA, or an FTA card. Our ISO‑certified phlebotomists ensure cold‑chain transport to guarantee sample integrity.

3. What is the turnaround time and cost?

Results are typically available in 3–4 weeks. The cost is 2,800 AED inclusive of genetic counselling. This covers sequencing, bioinformatic analysis, and a detailed clinical report interpreted by a genetics specialist. Insurance pre‑approval can be arranged via WhatsApp.

4. What conditions does the test detect?

The test detects pathogenic variants in the MAPK10 gene associated with epileptic encephalopathy, Lennox‑Gastaut type. It identifies missense, nonsense, frameshift, splice‑site, and copy‑number variants that lead to this severe childhood epilepsy syndrome.

UAE Regulatory & Data Privacy Adherence

Your Data and Rights Protected Under UAE Law

DNA Labs UAE fully complies with Federal Decree‑Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. All genetic information is encrypted, access‑controlled, and used solely for diagnostic purposes with your explicit consent. Our DHA‑licensed facility (License 1143) ensures that your clinical data remains confidential and secure.

Clinical & Logistical Metadata

Test Name	MAPK10 Gene Epileptic Encephalopathy, Lennox‑Gastaut Type Genetic Test (NGS)
Price (AED)	2,800
Turnaround Time	3–4 weeks
Sample Type / Matrix	Whole blood, extracted DNA, or FTA card
Methodology Used	Next‑Generation Sequencing (NGS) with CNV detection
ICD-10-CM Code	G40.4 (Lennox‑Gastaut syndrome), G40.9 (Epilepsy unspecified)
LOINC Code	81247-9 (Genetic test panel)
DHA Facility License & Laboratory Address	DNA Labs UAE \| DHA License: 1143 \| Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE