Test Price
2,800 AED✅ Home Collection Available
CHRNA2 Gene Sequencing: Nocturnal Frontal Lobe Epilepsy Type 4 – Genetic Test in UAE | 2800 AED | 2026 DHA Guidelines
تحليل جين CHRNA2 للصرع الجبهي الليلي النوع الرابع في الإمارات | 2800 درهم | معتمد من هيئة الصحة بدبي
Executive Summary الملخص التنفيذي
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015 accredited NGS processing (Cert: INT/EGQ/2509DA/3139).
- Premium Logistics: Paid Hospital‑Grade Home Collection via ISO Certified Cold‑Chain Home Collection; VIP Mobile Phlebotomy available 8 AM – 11 PM.
- Clinical Guidance: Telephonic post‑test clinical guidance in result interpretation included.
- Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.
Comprehensive NGS‑Based CHRNA2 Gene Test for Nocturnal Frontal Lobe Epilepsy
This advanced genetic test screens the entire coding region of the CHRNA2 gene for pathogenic variants causing autosomal dominant nocturnal frontal lobe epilepsy type 4. Delivered with a fast 3–4‑week turnaround, it provides a definitive molecular diagnosis for targeted neurological care. يُحلل هذا الفحص الجيني المتطور جين CHRNA2 بالكامل لتأكيد تشخيص الصرع الجبهي الليلي الوراثي من النوع الرابع، مما يُتيح تخطيطاً علاجياً دقيقاً.
| Feature | Our Test (Prime NGS) | Closest Alternative (Single‑Gene Sanger) |
|---|---|---|
| Precision | 99.9% sensitivity, full gene sequencing incl. deep intronic regions | >99% but limited to known hotspot mutations; misses rare variants |
| Methodology | Next‑Generation Sequencing (NGS) with transcriptome‑aware alignment | Sanger sequencing; lower multiplex capacity |
| Turnaround Time | 3–4 weeks | 4–6 weeks |
| Regulatory Alignment | DHA 2026, UAE PDPL & Federal Decree‑Law No. 41 of 2024 (Art. 87) | May not explicitly meet new genetic governance rules |
Physician Insight & Safety Protocol
Dr. Prabhakar Reddy (DHA: 61713011): “A positive variant in CHRNA2 must be interpreted alongside a detailed clinical history and a three‑generation pedigree. This test is a powerful clue, not a standalone verdict — always correlate with seizure semiology and EEG findings before finalising management.”
Medication Warning: Do not discontinue any prescribed antiepileptic drug or alter dosage without consulting your treating neurologist.
Patient Safety Exclusion Criteria & Emergency Red Flags
- Exclusion: Inability to provide informed consent (mandatory genetic counselling session per CDS Law 2026 for minors).
- Exclusion: Sample haemolysis or insufficient DNA yield — recollection will be advised at no additional phlebotomy cost.
- ER Red Flag: If you experience a prolonged seizure (>5 minutes) or cluster of seizures, seek immediate emergency care; do not wait for genetic results.
- ER Red Flag: New‑onset confusion or unsteadiness during sample shipping window — go to ER.
Frequently Asked Questions (FAQs)
1. Is CHRNA2 gene testing definitive for nocturnal frontal lobe epilepsy type 4?
This NGS test detects pathogenic CHRNA2 variants with 99.9% accuracy to confirm the molecular subtype of autosomal dominant nocturnal frontal lobe epilepsy, enabling precise genetic counselling and prognostication.
2. هل يتطلب فحص CHRNA2 استشارة وراثية قبل أخذ العينة؟
نعم، يُوصى بجلسة استشارة وراثية لتوثيق التاريخ العائلي ورسم شجرة النسب قبل الفحص، وفقاً لقانون الخدمات الجينية الإماراتي 2026، لضمان فهم النتائج وتأثيرها على العائلة.
3. Can I use my FTA card sample instead of a blood draw?
Whole blood, extracted DNA, or a single drop on an FTA card are all accepted, provided the card is properly dried and shipped at ambient temperature via ISO‑certified cold‑chain logistics to maintain DNA integrity.
compliant with Federal Decree‑Law No. 41 of 2024 (Article 87 – Genetic Services Governance), UAE CDS Law 2026 (Minors’ Consent), and UAE PDPL. ISO 9001:2015 Certified (Cert: INT/EGQ/2509DA/3139). Facility License: 9834453.
Contact & WhatsApp Support: +971 54 548 8731
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