Early Infantile Epileptic Encephalopathy (EIEE) Gene Panel – Diagnostic NGS Panel in Dubai

Executive Summary & Core Metrics

Accuracy Guarantee: 99.9% diagnostic sensitivity via ISO 15189 accredited NGS processing.

Premium Logistics: VIP mobile phlebotomy & temperature‑controlled cold‑chain home collection available for peripheral blood samples (daily 8 AM–11 PM). Prenatal invasive samples (amniotic fluid, chorionic villus) require hospital‑only extraction.

Clinical Guidance: Post‑test telephonic result interpretation by a board‑certified clinical geneticist.

Insurance: Direct billing verification via WhatsApp +971 54 548 8731.

Test Overview & Methodology

Overview

The Early Infantile Epileptic Encephalopathy (EIEE) Gene Panel analyzes more than 50 genes associated with severe early‑onset epilepsy syndromes. Using next‑generation sequencing (NGS), this test provides a definitive genetic diagnosis to guide personalised antiepileptic therapy and family counselling. Results must always be correlated with clinical history and EEG findings.

Test Comparison

Feature	Our Test (EIEE Panel)	Single‑Gene Sequencing
Precision	Comprehensive NGS panel covering 50+ genes	Targeted to one gene at a time
Method	Next‑Generation Sequencing (NGS)	Sanger Sequencing
Speed (Turnaround Time)	4–6 weeks	6–12 weeks per gene
Cost Efficiency	4,800 AED for all genes	Often >15,000 AED cumulative

Physician Insight & Safety Protocols

“As a Consultant Medical Genetics specialist, I stress that this gene panel provides high‑diagnostic yield, but results must never be interpreted in isolation. Integrating clinical history, EEG patterns, and family pedigree ensures accurate diagnosis and tailored treatment. Your child’s safety and wellbeing are our paramount concern.”

— Lina Osama Zaki Quteineh | Consultant Medical Genetics | DHA Registration ID: 9294403

Medication Advisory

⚠️ Do Not Discontinue Prescribed Medication

Adjusting antiepileptic drugs without medical guidance may trigger life‑threatening seizures. Always consult your physician before any changes.

Safety Exclusion Criteria & Red Flags

Exclusion Criteria

This test is not indicated for children with acute illness, unstable metabolic disorders, or when a valid sample cannot be obtained.
Prenatal testing (amniocentesis, chorionic villus sampling) is available only through hospital‑based extraction and requires explicit parental consent and adherence to DHA prenatal guidelines.

ER Red Flags

If the child experiences a seizure lasting longer than 5 minutes, cyanosis, respiratory distress, or loss of consciousness (after sample collection – very rare), seek emergency care immediately. These symptoms are related to the underlying condition, not the test itself.

Patient FAQ & Clinical Guidance

1. What is the accuracy of the EIEE gene panel for diagnosing epilepsy syndromes?

The panel achieves over 99% diagnostic sensitivity for targeted genes using ISO 15189‑validated NGS technology, detecting single nucleotide variants and copy number variations with high reproducibility. Confirmation by Sanger sequencing is performed for all clinically relevant variants.

2. Can prenatal samples be used for this panel?

Yes, we accept amniotic fluid or chorionic villus samples obtained under strict sterile and cold‑chain protocols. Results guide early intervention and informed reproductive choices. Collection must occur at an accredited hospital.

3. How long does it take to receive results and what support is provided?

Results are delivered within 4–6 weeks. Each report includes a telephonic consultation with a clinical geneticist to explain implications. Expedited reporting is available for urgent neonatal cases upon request.

UAE Regulatory & Data Privacy Adherence

Data Protection & Compliance

All genetic data is protected under Federal Decree‑Law No. 45 of 2021 on Personal Data Protection (PDPL).
Health information handling complies with Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields.
Clinical testing safety and patient consent follow Federal Decree‑Law No. 4 of 2016 on Medical Liability.
Results are disclosed only to the ordering physician or legal guardian with explicit written consent.

DNA Labs UAE holds DHA Facility License No. 1143 and adheres to all UAE healthcare regulations.

Clinical & Logistical Metadata

Test Name	Early Infantile Epileptic Encephalopathy (EIEE) Gene Panel
Price (AED)	4,800 AED
Turnaround Time	4–6 weeks (expedited options available)
Sample Type / Matrix	Peripheral whole blood (standard); prenatal invasive samples (amniotic fluid, chorionic villus) – hospital extraction only
Methodology Used	Next‑Generation Sequencing (NGS) – Ion Torrent / Illumina platforms; Sanger confirmation
ICD‑10‑CM Code	G40.4 (Other generalized epilepsy and epileptic syndromes)
LOINC Code	90270‑5 (Epilepsy and seizure comprehensive gene panel)
DHA Facility License & Address	License No. 1143 \| Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE – DNA Labs UAE