Test Price
1,200 AED✅ Home Collection Available
BCL2/IGH (t14;18) Translocation FISH Test in UAE | 1200 AED | DHA Licensed
Executive Summary & Core Metrics
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity achieved via ISO 9001:2015 accredited FISH processing, utilizing dual‑fusion break‑apart probes for unambiguous translocation detection.
- Specimen Logistics: Archival Tissue Specimen – Secure Medical Courier Solid Tissue Specimen Retrieval. Sample is collected from existing biopsy material (FFPE blocks or slides). No home phlebotomy or hospital extraction required.
- Clinical Guidance: Post‑test telephonic clinical correlation by a DHA‑licensed specialist to interpret results in context of your complete medical picture.
- Insurance: Direct Billing Verification via WhatsApp at +971 54 548 8731 – submit your policy details for instant pre‑approval.
Test Overview & Methodology
The BCL2/IGH (t14;18) translocation is a hallmark chromosomal abnormality in follicular lymphoma, detected by Fluorescence In‑Situ Hybridization (FISH) on tumor tissue. This test provides definitive molecular evidence of the juxtaposition of the BCL2 oncogene with the immunoglobulin heavy chain locus, driving overexpression of the anti‑apoptotic BCL2 protein.
| Feature | Our BCL2/IGH FISH Test | Closest Alternative (BCL2 IHC) |
|---|---|---|
| Detection Principle | Direct visualization of DNA rearrangement via FISH break‑apart probes | Indirect protein overexpression by immunohistochemistry |
| Sensitivity & Specificity | 99.9% sensitivity, near‑100% specificity for t(14;18) | ~85% sensitivity; cannot distinguish translocation‑driven vs. physiological BCL2 expression |
| Turnaround Time | 7–8 working days | 2–3 working days, but often requires reflex FISH for confirmation |
| Clinical Utility | Gold standard for diagnosis, minimal residual disease monitoring, and therapeutic stratification | Screening tool with potential false‑positives/negatives; not a standalone diagnostic |
Physician Insight & Safety Protocols
“In my clinical practice, the BCL2/IGH translocation FISH test is a cornerstone in confirming follicular lymphoma and guiding targeted therapies. However, a positive result must always be interpreted alongside marrow morphology, immunophenotyping, and the patient’s clinical presentation. A negative result, while reassuring, does not entirely exclude lymphoma, especially in high‑grade transformations.”
— Mr. Prabhakar Reddy Kalathoor, Specialist Diagnostic Radiology | DHA Registration ID: 61713011
Safety Exclusion Criteria & Red Flags
- Inadequate or non‑representative tumor tissue; repeat biopsy may be required.
- Patients with severe bleeding diathesis precluding biopsy.
- Pregnancy or emergency surgery cases where tissue sampling is deferred (prescription exemption applies).
- Red Flag: If the test is positive and you experience new B‑symptoms (fever, night sweats, weight loss), seek immediate oncology consultation. Negative FISH does not rule out aggressive lymphoma transformation; urgent histological correlation is advised.
Medication Advisory
Do not discontinue any prescribed medication, including targeted therapy or immunosuppressants, without consulting your treating physician. Test results are for diagnostic clarity and must never be used to alter your treatment plan independently.
Patient FAQ & Clinical Guidance
1. What does a positive BCL2/IGH (t14;18) result mean for my diagnosis?
Direct Answer: A positive result strongly supports a diagnosis of follicular lymphoma, confirming the hallmark gene rearrangement that causes uncontrolled B‑cell survival.
2. How should I prepare for the tumor tissue collection procedure?
Direct Answer: A doctor’s prescription is required except for pregnancy or emergency surgery; no fasting is needed, but the biopsy site must be intact. The test uses archival tissue from your existing biopsy, so no new collection is required.
3. Can this test monitor my lymphoma after treatment?
Direct Answer: Yes, serial FISH testing can detect minimal residual disease and early recurrence with high sensitivity, guiding maintenance therapy decisions.
4. Is home collection available for this test?
Direct Answer: No. This test requires archival tissue specimens (FFPE blocks or slides) that are retrieved from the hospital or pathology lab via secure medical courier. Mobile phlebotomy is not applicable.
UAE Regulatory & Data Privacy Adherence
Regulatory Compliance
This service adheres to the following UAE legal frameworks:
- Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) – all genetic data processed with explicit patient consent and secure handling.
- Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields – for digital health data transmission and storage.
- Federal Decree-Law No. 4 of 2016 on Medical Liability – governing clinical testing safety and patient consent.
- ISO 9001:2015 Certified (Cert: INT/EGQ/2509DA/3139) – all laboratory processes meet international quality standards.
Clinical & Logistical Metadata
| Test Name | BCL2/IGH (t14;18) Translocation FISH Test |
| Price (AED) | 1,200 AED (inclusive of VAT) |
| Turnaround Time | 7 – 8 working days |
| Sample Type / Matrix | Archival Tissue Specimen (FFPE tissue blocks or slides) – Secure Medical Courier Solid Tissue Specimen Retrieval |
| Methodology Used | Fluorescence In‑Situ Hybridization (FISH) – Dual‑fusion break‑apart probes |
| ICD-10-CM Code | C82.9 (Follicular lymphoma, unspecified) |
| LOINC Code | 87783-7 (BCL2/IGH rearrangement by FISH) |
| DHA Facility License & Address | License No. 1143 – Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE – DNA Labs UAE |
Contact WhatsApp: +971 54 548 8731 | Service Hours: 8 AM – 11 PM daily
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