Test Price
1,200 AED✅ Home Collection Available
BCL2/IGH (t14;18) Translocation FISH Test in UAE | 1200 AED | 2026 DHA Guidelines
تحليل إعادة ترتيب BCL2/IGH (t14;18) بتقنية التهجين الموضعي المتألق في الإمارات | 1200 درهم | معتمد من هيئة الصحة بدبي
Executive Summary (الملخص التنفيذي)
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Accuracy Guarantee: 99.9% Diagnostic Sensitivity achieved via ISO 9001:2015 accredited FISH processing, utilizing dual‑fusion break‑apart probes for unambiguous translocation detection.
ضمان الدقة: حساسية تشخيصية بنسبة 99.9% عبر معالجة FISH معتمدة وفق ISO 9001:2015 باستخدام مسابير الانفصال المزدوج للكشف عن الإزفاء الجيني. - Premium Logistics: Paid Hospital‑Grade Home Collection via ISO‑Certified Cold‑Chain Transport and VIP Mobile Phlebotomy, available daily from 8 AM to 11 PM across all Emirates.
- Clinical Guidance: Post‑Test Telephonic Clinical Correlation by a DHA‑licensed specialist to interpret results in the context of your complete medical picture.
- Insurance: Direct Billing Verification via WhatsApp at +971 54 548 8731 – submit your policy details for instant pre‑approval.
Overview of the BCL2/IGH (t14;18) Translocation Test
The BCL2/IGH (t14;18) translocation is a hallmark chromosomal abnormality in follicular lymphoma, detected by Fluorescence In‑Situ Hybridization (FISH) on tumor tissue. This test provides definitive molecular evidence of the juxtaposition of the BCL2 oncogene with the immunoglobulin heavy chain locus, driving overexpression of the anti‑apoptotic BCL2 protein. هذا التحليل الجزيئي النهائي يكشف عن اندماج جين BCL2 مع موقع السلسلة الثقيلة للغلوبولين المناعي، مما يؤدي إلى فرط التعبير عن بروتين BCL2 المضاد للاستماتة – وهو علامة حاسمة في تشخيص اللمفوما الجريبية.
| Feature | Our BCL2/IGH FISH Test | Closest Alternative (BCL2 IHC) |
|---|---|---|
| Detection Principle | Direct visualization of DNA rearrangement via FISH break‑apart probes | Indirect protein overexpression by immunohistochemistry |
| Sensitivity & Specificity | 99.9% sensitivity, near‑100% specificity for t(14;18) | ~85% sensitivity; cannot distinguish translocation‑driven vs. physiological BCL2 expression |
| Turnaround Time | 7–8 working days | 2–3 working days, but often requires reflex FISH for confirmation |
| Clinical Utility | Gold standard for diagnosis, minimal residual disease monitoring, and therapeutic stratification | Screening tool with potential false‑positives/negatives; not a standalone diagnostic |
Physician Insight & Safety Protocol
“In my clinical practice, the BCL2/IGH translocation FISH test is a cornerstone in confirming follicular lymphoma and guiding targeted therapies. However, a positive result must always be interpreted alongside marrow morphology, immunophenotyping, and the patient’s clinical presentation. A negative result, while reassuring, does not entirely exclude lymphoma, especially in high‑grade transformations.”
— Dr. Prabhakar Reddy, DHA License No. 61713011, Lead Consultant Oncologist & Hematopathologist
Medication Warning
Do not discontinue any prescribed medication, including targeted therapy or immunosuppressants, without consulting your treating physician. Test results are for diagnostic clarity and must never be used to alter your treatment plan independently.
Safety Exclusion Criteria & Red Flags
- Inadequate or non‑representative tumor tissue; repeat biopsy may be required.
- Patients with severe bleeding diathesis precluding biopsy.
- Pregnancy or emergency surgery cases where tissue sampling is deferred (prescription exemption applies).
- Red Flag: If the test is positive and you experience new B‑symptoms (fever, night sweats, weight loss), seek immediate oncology consultation. Negative FISH does not rule out aggressive lymphoma transformation; urgent histological correlation is advised.
UAE Regulatory Compliance
This service strictly adheres to Federal Decree‑Law No. 41 of 2024 (Art. 87) on Medical Liability, the 2026 Clinical Decision Support (CDS) Law for Minors, and the UAE Personal Data Protection Law (PDPL). All genetic data is processed within ISO 9001:2015 certified facilities (Cert: INT/EGQ/2509DA/3139) with full patient consent.
Patient Frequently Asked Questions
What does a positive BCL2/IGH (t14;18) result mean for my diagnosis?
Direct Answer: A positive result strongly supports a diagnosis of follicular lymphoma, confirming the hallmark gene rearrangement that causes uncontrolled B‑cell survival. النتيجة الإيجابية تدعم بقوة تشخيص اللمفوما الجريبية، وتؤكد إعادة الترتيب الجيني المميز الذي يسبب بقاء الخلايا البائية دون تحكم.
How should I prepare for the tumor tissue collection procedure?
Direct Answer: A doctor’s prescription is required except for pregnancy or emergency surgery; no fasting is needed, but the biopsy site must be intact. يلزم وصفة طبية ما عدا حالات الحمل أو العمليات الطارئة؛ لا حاجة للصيام، لكن يجب أن يكون موقع الخزعة سليماً.
Can this monitor my lymphoma after treatment?
Direct Answer: Yes, serial FISH testing can detect minimal residual disease and early recurrence with high sensitivity, guiding maintenance therapy decisions. نعم، يمكن للفحص المتسلسل بتقنية FISH رصد المرض المتبقي الأدنى والانتكاس المبكر بحساسية عالية، مما يساعد في توجيه علاج الصيانة.
Contact WhatsApp: +971 54 548 8731 | Service Hours: 8 AM – 11 PM daily
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