Test Price
2,000 AED✅ Home Collection Available
AML FISH Panel – Acute Myeloid Leukemia Genetic Panel (4 Rearrangements) in Dubai, UAE
Executive Summary & Core Metrics
- Diagnostic Accuracy: 99.9% sensitivity using ISO 9001:2015 validated processes and enhanced FISH probes.
- Logistical Service: Hospital extraction only – sample collection conducted strictly within an accredited hospital facility; mobile home phlebotomy is disabled for safety.
- Clinical Guidance: Post-test telephone consultation for result interpretation and follow-up planning provided by a board-certified medical genetics specialist.
- Insurance Support: Direct billing verification and insurance coverage assistance via WhatsApp +971 54 548 8731.
Test Overview & Methodology
The AML FISH Panel is a targeted fluorescence in-situ hybridization assay that rapidly detects four critical chromosomal rearrangements—t(8;21)(q22;q22) / AML1-ETO, inv(16)(p13.1q22) / CBFB-MYH11, t(15;17)(q24.1;q21.2) / PML-RARA, and rearrangements involving 11q23 / MLL (KMT2A). These markers are essential for classifying acute myeloid leukemia subtypes, determining risk stratification, and guiding targeted therapies such as all-trans retinoic acid and gemtuzumab ozogamicin. The test is performed on bone marrow aspirate or peripheral blood specimens.
| Parameter | Our Test (ISO 9001:2015) | Closest Alternative |
|---|---|---|
| Precision | 99.9% Diagnostic Sensitivity | Standard FISH ~97% |
| Methodology | Enhanced FISH with Validated Dual‑Color Probes | Conventional FISH or Karyotyping |
| Turnaround Time | 10 Business Days (Expedited Reporting) | 14–21 Days |
Physician Insight & Safety Protocols
“This AML FISH panel delivers rapid molecular clarification of prognostic and therapeutic targets; however, results must always be correlated with bone marrow morphology, immunophenotyping, and clinical history. Patients should not discontinue any prescribed therapy based solely on these findings without consulting their hematologist.”
— Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
⚠️ Advisory Notice
- This test is not a substitute for a complete hematological workup; false-negative results may occur in low-level disease.
- Do not discontinue prescribed medication (e.g., chemotherapy, tyrosine kinase inhibitors) without explicit oncologist approval.
- Bone marrow or peripheral blood must be transported immediately per cold-chain protocol; delays may compromise cell viability.
Exclusion Criteria & Emergency Red Flags
- Specimen older than 24 hours without proper preservation.
- Severe hemolysis or clotting in the sample.
- Patient unable to provide informed consent (minors require legal guardian per Federal Decree-Law No. 4 of 2016).
ER Red Flags:
- Sudden fever, uncontrolled bleeding, or neurological symptoms in a patient with suspected AML.
- Rapidly deteriorating clinical condition; seek emergency care immediately.
Patient FAQ & Clinical Guidance
1. What is the AML FISH Panel and why is it done?
The AML FISH Panel uses fluorescent DNA probes to detect four major chromosomal rearrangements—t(8;21), inv(16), t(15;17), and MLL (11q23)—providing rapid, targeted genetic information that guides AML subtype classification and personalized therapy decisions.
2. How is the sample collected and what preparation is needed?
Sample collection is performed strictly within an accredited hospital facility. Bone marrow aspiration is the preferred specimen; peripheral blood may also be accepted. No fasting is required. Inform your doctor about any anticoagulant medications. A valid prescription from a physician is necessary for testing.
3. How reliable is the result and can it be used for treatment decisions?
With 99.9% diagnostic sensitivity and ISO‑9001:2015 validated processing, this panel provides highly reliable molecular markers for risk stratification and targeted therapy selection. However, your hematologist or oncologist will integrate these findings with full clinical, morphological, and immunophenotypic data before finalizing any treatment plan.
UAE Regulatory & Data Privacy Adherence
Regulatory Compliance: This test adheres to Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Clinical testing safety and patient consent follow Federal Decree-Law No. 4 of 2016 on Medical Liability. DNA Labs UAE operates under DHA Facility License Number 1143 and is located at Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE.
Clinical & Logistical Metadata
| Test Name | AML FISH Panel – 4 Rearrangements (AML1-ETO, CBFB-MYH11, PML-RARA, MLL) |
| Price (AED) | 2,000 |
| Turnaround Time | 10 Business Days |
| Sample Type / Matrix | Bone Marrow Aspirate or Peripheral Blood (Hospital Extraction Only) |
| Methodology Used | Fluorescence In-Situ Hybridization (FISH) with Dual-Color Break-Apart and Fusion Probes |
| ICD-10-CM Code | C92.00 (Acute myeloblastic leukemia, not having achieved remission), C92.50 (Acute myelomonocytic leukemia), Z15.01 (Genetic susceptibility to malignant neoplasm) |
| LOINC Code | 96589-0 (Acute myeloid leukemia FISH panel - Blood or Bone marrow) |
| DHA Facility License & Laboratory Address | License Number: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE (DNA Labs UAE) |
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All reports reviewed by DHA-Certified physicians