Test Price
2,800 AEDโ Home Collection Available
PROS1 Gene Protein S Deficiency Genetic Test in UAE
Executive Summary & Core Metrics
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015 Accredited Processing.
- Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection (available daily 8 AM to 11 PM).
- Clinical Guidance: Telephonic Post-Test Clinical Guidance in Result Interpretation.
- Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.
Test Overview & Methodology
This advanced Next-Generation Sequencing (NGS) genetic test screens the entire PROS1 gene for pathogenic variants causing autosomal dominant Protein S deficiency, a major inherited risk factor for venous thromboembolism. In the UAE, this test provides definitive molecular diagnosis and guides personalized thromboprophylaxis.
| Parameter | Our Test (NGS Full Gene) | Closest Alternative (Functional Assay) |
|---|---|---|
| Precision | >99.9% analytical sensitivity & specificity for nucleotide variants | ~95% sensitivity; influenced by acute phase reactions, anticoagulants |
| Methodology | NGS (LC-MS/MS validated for complex regions) | Clotting-based (PTT-based) functional protein S activity |
| Turnaround Time | 3 to 4 Weeks | 3โ5 working days |
Physician Insight & Safety Protocols
Lina Osama Zaki Quteineh | Consultant Medical Genetics | DHA Registration ID: 9294403
Genetic testing for Protein S deficiency must be interpreted in the context of personal and family history of thrombosis. A positive result identifies an inherited predisposition, not a current clot, and requires careful clinical correlation. This test is a molecular diagnostic tool โ always discuss results with your treating specialist before making any health decisions.
Advisory Notice
โ ๏ธ Important
Do not discontinue prescribed anticoagulants or other medications without consulting your doctor. This genetic test does not replace acute clinical management.
Patient Safety: Exclusion Criteria & Emergency Red Flags
- This test is not intended for individuals currently experiencing an acute thrombotic event (deep vein thrombosis, pulmonary embolism) โ seek immediate emergency care.
- Not suitable as a point-of-care test; does not provide real-time clotting status.
- Patients with a recent blood transfusion or bone marrow transplant may have donor DNA interference โ consult lab before sample collection.
- Red Flag Symptoms: sudden chest pain, shortness of breath, leg swelling with redness/warmth, coughing up blood โ call 998 or visit the nearest emergency room immediately.
Patient FAQ & Clinical Guidance
1. How does the PROS1 NGS test differ from a standard protein S functional assay?
This genetic test provides a stable, lifetime result unaffected by transient conditions. A positive genetic finding confirms the hereditary nature and guides family screening.
2. Can I take this test if I am currently on blood thinners?
Yes, because the PROS1 genetic test analyzes DNA, not clotting function. The sample can be collected as whole blood, extracted DNA, or a dried blood spot, making it convenient even for patients on chronic therapy.
3. What is the turnaround time and how will I receive my results?
Results are delivered within 3 to 4 weeks via a secure encrypted PDF report, accompanied by a complimentary telephonic interpretation session with a specialist. The report details detected variants, pathogenicity classification, and clinical correlation recommendations. Family pedigree mapping is also available.
UAE Regulatory & Data Privacy Adherence
This service is fully compliant with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Federal Decree-Law No. 4 of 2016 on Medical Liability governs clinical testing safety and patient consent. Our facility (DHA License: 1143) is ISO 9001:2015 certified (Cert: INT/EGQ/2509DA/3139), ensuring stringent quality management. All genetic data is encrypted and retained under strict confidentiality protocols.
Clinical & Logistical Metadata
| Test Name | PROS1 Gene Sequencing (Next-Generation Sequencing) |
| Price (AED) | 2,800 |
| Turnaround Time | 3 to 4 Weeks |
| Sample Type / Matrix | Peripheral Whole Blood (EDTA). VIP Mobile Phlebotomy & Cold-Chain Home Collection available daily 8 AM to 11 PM. |
| Methodology Used | Next-Generation Sequencing (NGS) |
| ICD-10-CM Code | D68.59 (Other thrombophilia) |
| LOINC Code | 82186-7 (Gene analysis for hereditary thrombophilia) |
| DHA Facility License & Address | License #1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | DNA Labs UAE |
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